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- W1935886040 endingPage "2609" @default.
- W1935886040 startingPage "2600" @default.
- W1935886040 abstract "Abstract Clinical investigations have revealed that infusion of immunotherapeutic mAbs directed to normal or tumor cells can lead to loss of targeted epitopes, a phenomenon called antigenic modulation. Recently, we reported that rituximab treatment of chronic lymphocytic leukemia patients induced substantial loss of CD20 on B cells found in the circulation after rituximab infusion, when rituximab plasma concentrations were high. Such antigenic modulation can severely compromise therapeutic efficacy, and we postulated that B cells had been stripped (shaved) of the rituximab/CD20 complex by monocytes or macrophages in a reaction mediated by FcγR. We developed an in vitro model to replicate this in vivo shaving process, based on reacting rituximab-opsonized CD20+ cells with acceptor THP-1 monocytes. After 45 min at 37°C, rituximab and CD20 are removed from opsonized cells, and both are demonstrable on acceptor THP-1 cells. The reaction occurs equally well in the presence and absence of normal human serum, and monocytes isolated from peripheral blood also promote shaving of CD20 from rituximab-opsonized cells. Tests with inhibitors and use of F(ab′)2 of rituximab indicate transfer of rituximab/CD20 complexes to THP-1 cells is mediated by FcγR. Antigenic modulation described in previous reports may have been mediated by such shaving, and our findings may have profound implications for the use of mAbs in the immunotherapy of cancer." @default.
- W1935886040 created "2016-06-24" @default.
- W1935886040 creator A5006499454 @default.
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- W1935886040 creator A5020347433 @default.
- W1935886040 creator A5068419795 @default.
- W1935886040 creator A5074865442 @default.
- W1935886040 date "2006-02-15" @default.
- W1935886040 modified "2023-10-18" @default.
- W1935886040 title "The Shaving Reaction: Rituximab/CD20 Complexes Are Removed from Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Cells by THP-1 Monocytes" @default.
- W1935886040 cites W1505046337 @default.
- W1935886040 cites W1509374036 @default.
- W1935886040 cites W1512026049 @default.
- W1935886040 cites W1527999229 @default.
- W1935886040 cites W1529163702 @default.
- W1935886040 cites W1534748037 @default.
- W1935886040 cites W1566055938 @default.
- W1935886040 cites W1579718268 @default.
- W1935886040 cites W1581933655 @default.
- W1935886040 cites W1583267779 @default.
- W1935886040 cites W1633176708 @default.
- W1935886040 cites W183967228 @default.
- W1935886040 cites W1871950693 @default.
- W1935886040 cites W1885961362 @default.
- W1935886040 cites W1897592311 @default.
- W1935886040 cites W1915689252 @default.
- W1935886040 cites W1926532709 @default.
- W1935886040 cites W1931324339 @default.
- W1935886040 cites W1965962344 @default.
- W1935886040 cites W1968706708 @default.
- W1935886040 cites W1979419663 @default.
- W1935886040 cites W1982369008 @default.
- W1935886040 cites W1985200042 @default.
- W1935886040 cites W1986495665 @default.
- W1935886040 cites W1989589268 @default.
- W1935886040 cites W1989916780 @default.
- W1935886040 cites W1990257353 @default.
- W1935886040 cites W1996455554 @default.
- W1935886040 cites W2012012527 @default.
- W1935886040 cites W2032837321 @default.
- W1935886040 cites W2034533024 @default.
- W1935886040 cites W2038354618 @default.
- W1935886040 cites W2044360617 @default.
- W1935886040 cites W2052232839 @default.
- W1935886040 cites W2058015212 @default.
- W1935886040 cites W2059519404 @default.
- W1935886040 cites W2059650905 @default.
- W1935886040 cites W2060408036 @default.
- W1935886040 cites W2063792914 @default.
- W1935886040 cites W2075595064 @default.
- W1935886040 cites W2075906979 @default.
- W1935886040 cites W2076106584 @default.
- W1935886040 cites W2076350188 @default.
- W1935886040 cites W2081518361 @default.
- W1935886040 cites W2082330770 @default.
- W1935886040 cites W2084271278 @default.
- W1935886040 cites W2088332148 @default.
- W1935886040 cites W2088547651 @default.
- W1935886040 cites W2100482220 @default.
- W1935886040 cites W2101417837 @default.
- W1935886040 cites W2108093856 @default.
- W1935886040 cites W2108556253 @default.
- W1935886040 cites W2109638333 @default.
- W1935886040 cites W2110105488 @default.
- W1935886040 cites W2110987088 @default.
- W1935886040 cites W2115310585 @default.
- W1935886040 cites W2115489142 @default.
- W1935886040 cites W2120418083 @default.
- W1935886040 cites W2121662877 @default.
- W1935886040 cites W2123602110 @default.
- W1935886040 cites W2127310510 @default.
- W1935886040 cites W2128402413 @default.
- W1935886040 cites W2129041705 @default.
- W1935886040 cites W2130672995 @default.
- W1935886040 cites W2130898938 @default.
- W1935886040 cites W2130926377 @default.
- W1935886040 cites W2132184728 @default.
- W1935886040 cites W2141139539 @default.
- W1935886040 cites W2153866355 @default.
- W1935886040 cites W2160835020 @default.
- W1935886040 cites W2168648203 @default.
- W1935886040 cites W2170938637 @default.
- W1935886040 cites W2236597033 @default.
- W1935886040 cites W2274305505 @default.
- W1935886040 cites W2288245591 @default.
- W1935886040 cites W2335889607 @default.
- W1935886040 cites W2477936151 @default.
- W1935886040 cites W2572974889 @default.
- W1935886040 cites W4241324576 @default.
- W1935886040 cites W4243906229 @default.
- W1935886040 cites W4248610467 @default.
- W1935886040 cites W4248698887 @default.
- W1935886040 cites W4249894065 @default.
- W1935886040 cites W4252256939 @default.
- W1935886040 doi "https://doi.org/10.4049/jimmunol.176.4.2600" @default.
- W1935886040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16456022" @default.
- W1935886040 hasPublicationYear "2006" @default.
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