Matches in SemOpenAlex for { <https://semopenalex.org/work/W1936150093> ?p ?o ?g. }
- W1936150093 endingPage "2601" @default.
- W1936150093 startingPage "2592" @default.
- W1936150093 abstract "Abstract Adiponectin (APN) is a crucial regulator for many inflammatory processes, but its effect on Th cell-mediated responses has not been fully understood. Thus, we investigated the immune-modulatory effects of APN on dendritic cells (DCs) controlling Th cell polarization. APN induced maturation and activation of DCs, as demonstrated by the increased expression of MHC class II, costimulatory molecules in both mouse and human DCs, and it significantly enhanced production of proinflammatory cytokines. APN triggered degradation of IκB proteins, nuclear translocation of NF-κB p65 subunit, and phosphorylation of MAPKs in DCs. Pretreatment with a phospholipase C (PLC)γ inhibitor and a JNK inhibitor suppressed IL-12 production and NF-κB binding activity. Additionally, PLCγ inhibitor downregulated phosphorylation of JNK, indicating that PLCγ and JNK may be upstream molecules of NF-κB. Importantly, APN-treated DCs significantly induced both Th1 and Th17 responses in allogeneic CD4+ T cells. The addition of a neutralizing anti–IL-12 mAb to the cocultures abolished the secretion of IFN-γ, whereas the blockage of IL-23 and IL-1β suppressed APN-induced IL-17 production. Immunization of mice with OVA-pulsed, APN-treated DCs efficiently led to Ag-specific Th1 and Th17 cell responses. Taken together, these results demonstrated that APN effectively induced activation of DCs through PLCγ/JNK/NF-κB-signaling pathways, leading to enhanced Th1 and Th17 responses." @default.
- W1936150093 created "2016-06-24" @default.
- W1936150093 creator A5017055996 @default.
- W1936150093 creator A5024442081 @default.
- W1936150093 creator A5026511476 @default.
- W1936150093 creator A5079679300 @default.
- W1936150093 creator A5081607244 @default.
- W1936150093 date "2012-03-15" @default.
- W1936150093 modified "2023-09-27" @default.
- W1936150093 title "Adiponectin Induces Dendritic Cell Activation via PLCγ/JNK/NF-κB Pathways, Leading to Th1 and Th17 Polarization" @default.
- W1936150093 cites W1494472252 @default.
- W1936150093 cites W1558372199 @default.
- W1936150093 cites W1585462962 @default.
- W1936150093 cites W1969573745 @default.
- W1936150093 cites W1972698666 @default.
- W1936150093 cites W1980295353 @default.
- W1936150093 cites W1986437675 @default.
- W1936150093 cites W1987963517 @default.
- W1936150093 cites W1991264736 @default.
- W1936150093 cites W1997978122 @default.
- W1936150093 cites W2000265203 @default.
- W1936150093 cites W2005276831 @default.
- W1936150093 cites W2012973306 @default.
- W1936150093 cites W2014750930 @default.
- W1936150093 cites W2021904780 @default.
- W1936150093 cites W2025492877 @default.
- W1936150093 cites W2029437196 @default.
- W1936150093 cites W2038018821 @default.
- W1936150093 cites W2038280977 @default.
- W1936150093 cites W2043958887 @default.
- W1936150093 cites W2053911884 @default.
- W1936150093 cites W2060425051 @default.
- W1936150093 cites W2071497566 @default.
- W1936150093 cites W2076164775 @default.
- W1936150093 cites W2085275537 @default.
- W1936150093 cites W2085321949 @default.
- W1936150093 cites W2088876995 @default.
- W1936150093 cites W2097087846 @default.
- W1936150093 cites W2099458192 @default.
- W1936150093 cites W2108373826 @default.
- W1936150093 cites W2108557146 @default.
- W1936150093 cites W2112114331 @default.
- W1936150093 cites W2112866067 @default.
- W1936150093 cites W2117047064 @default.
- W1936150093 cites W2117740888 @default.
- W1936150093 cites W2123688428 @default.
- W1936150093 cites W2138750223 @default.
- W1936150093 cites W2141664407 @default.
- W1936150093 cites W2143036961 @default.
- W1936150093 cites W2143556364 @default.
- W1936150093 cites W2146444493 @default.
- W1936150093 cites W2147168728 @default.
- W1936150093 cites W2152201021 @default.
- W1936150093 cites W2165098103 @default.
- W1936150093 cites W2166676682 @default.
- W1936150093 cites W2167246791 @default.
- W1936150093 cites W4246077736 @default.
- W1936150093 doi "https://doi.org/10.4049/jimmunol.1102588" @default.
- W1936150093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22345647" @default.
- W1936150093 hasPublicationYear "2012" @default.
- W1936150093 type Work @default.
- W1936150093 sameAs 1936150093 @default.
- W1936150093 citedByCount "72" @default.
- W1936150093 countsByYear W19361500932012 @default.
- W1936150093 countsByYear W19361500932013 @default.
- W1936150093 countsByYear W19361500932014 @default.
- W1936150093 countsByYear W19361500932015 @default.
- W1936150093 countsByYear W19361500932016 @default.
- W1936150093 countsByYear W19361500932017 @default.
- W1936150093 countsByYear W19361500932018 @default.
- W1936150093 countsByYear W19361500932019 @default.
- W1936150093 countsByYear W19361500932020 @default.
- W1936150093 countsByYear W19361500932021 @default.
- W1936150093 countsByYear W19361500932022 @default.
- W1936150093 countsByYear W19361500932023 @default.
- W1936150093 crossrefType "journal-article" @default.
- W1936150093 hasAuthorship W1936150093A5017055996 @default.
- W1936150093 hasAuthorship W1936150093A5024442081 @default.
- W1936150093 hasAuthorship W1936150093A5026511476 @default.
- W1936150093 hasAuthorship W1936150093A5079679300 @default.
- W1936150093 hasAuthorship W1936150093A5081607244 @default.
- W1936150093 hasBestOaLocation W19361500931 @default.
- W1936150093 hasConcept C11960822 @default.
- W1936150093 hasConcept C164027704 @default.
- W1936150093 hasConcept C185592680 @default.
- W1936150093 hasConcept C203014093 @default.
- W1936150093 hasConcept C2776090121 @default.
- W1936150093 hasConcept C2776914184 @default.
- W1936150093 hasConcept C2777730290 @default.
- W1936150093 hasConcept C2778170410 @default.
- W1936150093 hasConcept C62478195 @default.
- W1936150093 hasConcept C86803240 @default.
- W1936150093 hasConcept C8891405 @default.
- W1936150093 hasConcept C95444343 @default.
- W1936150093 hasConceptScore W1936150093C11960822 @default.
- W1936150093 hasConceptScore W1936150093C164027704 @default.
- W1936150093 hasConceptScore W1936150093C185592680 @default.
- W1936150093 hasConceptScore W1936150093C203014093 @default.