FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1936228450> ?p ?o ?g. }

• W1936228450 endingPage "290" @default.
• W1936228450 startingPage "283" @default.
• W1936228450 abstract "The metabolic effects of a protein-rich meal were studied for 3 h in 10 controls and in 20 cirrhotic patients. After protein ingestion, blood glucose did not vary significantly. Insulin and glucagon levels rose in controls and, more markedly, in cirrhotics. Aromatic amino acids and tryptophan increased more in cirrhotics as a result of their decreased liver function. Similarly, branched-chain amino acids increased by 153 +/- 14 nmol/ml X min (mean +/- SE) in controls and by 259 +/- 27 nmol/ml X min in cirrhotics (p less than 0.02), in the presence of a markedly increased insulin response. Branched-chain amino acid metabolism mainly occurs in skeletal muscle under insulin control; in cirrhosis, it might be reduced as a consequence of insulin resistance. To support this hypothesis, the effects of the protein meal were compared with those of an oral glucose load in 15 cirrhotic patients. Branched-chain amino acid response to protein ingestion significantly correlated with blood glucose response to oral glucose (r = 0.714), and with insulin resistance during the glucose tolerance test, when assessed by the insulinogenic index (r = 0.628). Similarly, in 8 patients, increased branched-chain amino acid response also correlated with the index of tissue sensitivity to insulin obtained by means of the glucose clamp technique during continuous insulin infusion (r = -0.809). We conclude that liver cirrhosis is characterized by an abnormal branched-chain amino acid response to protein ingestion, which matches the well-known intolerance to oral glucose. Both alterations are possibly due to decreased peripheral insulin activity on substrates." @default.
• W1936228450 created "2016-06-24" @default.
• W1936228450 creator A5010487468 @default.
• W1936228450 creator A5012262481 @default.
• W1936228450 creator A5012574576 @default.
• W1936228450 creator A5037005954 @default.
• W1936228450 creator A5037237635 @default.
• W1936228450 creator A5039273685 @default.
• W1936228450 creator A5054601014 @default.
• W1936228450 creator A5075442975 @default.
• W1936228450 creator A5085300062 @default.
• W1936228450 date "1983-08-01" @default.
• W1936228450 modified "2023-09-26" @default.
• W1936228450 title "Plasma amino acid response to protein ingestion in patients with liver cirrhosis" @default.
• W1936228450 cites W1495146887 @default.
• W1936228450 cites W1555155027 @default.
• W1936228450 cites W1571954921 @default.
• W1936228450 cites W1603688983 @default.
• W1936228450 cites W1967463743 @default.
• W1936228450 cites W1982399053 @default.
• W1936228450 cites W1994972342 @default.
• W1936228450 cites W2008251449 @default.
• W1936228450 cites W2016085079 @default.
• W1936228450 cites W2020115894 @default.
• W1936228450 cites W2029828243 @default.
• W1936228450 cites W2030800103 @default.
• W1936228450 cites W2031301857 @default.
• W1936228450 cites W2046684457 @default.
• W1936228450 cites W2065026248 @default.
• W1936228450 cites W2092700428 @default.
• W1936228450 cites W2092822692 @default.
• W1936228450 cites W2102941122 @default.
• W1936228450 cites W2107050786 @default.
• W1936228450 cites W2124134528 @default.
• W1936228450 cites W2142485606 @default.
• W1936228450 cites W2163532809 @default.
• W1936228450 cites W2167481594 @default.
• W1936228450 cites W2191492463 @default.
• W1936228450 cites W2328336350 @default.
• W1936228450 cites W28948492 @default.
• W1936228450 cites W4300572853 @default.
• W1936228450 doi "https://doi.org/10.1016/0016-5085(83)90312-8" @default.
• W1936228450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6345256" @default.
• W1936228450 hasPublicationYear "1983" @default.
• W1936228450 type Work @default.
• W1936228450 sameAs 1936228450 @default.
• W1936228450 citedByCount "31" @default.
• W1936228450 countsByYear W19362284502017 @default.
• W1936228450 countsByYear W19362284502022 @default.
• W1936228450 crossrefType "journal-article" @default.
• W1936228450 hasAuthorship W1936228450A5010487468 @default.
• W1936228450 hasAuthorship W1936228450A5012262481 @default.
• W1936228450 hasAuthorship W1936228450A5012574576 @default.
• W1936228450 hasAuthorship W1936228450A5037005954 @default.
• W1936228450 hasAuthorship W1936228450A5037237635 @default.
• W1936228450 hasAuthorship W1936228450A5039273685 @default.
• W1936228450 hasAuthorship W1936228450A5054601014 @default.
• W1936228450 hasAuthorship W1936228450A5075442975 @default.
• W1936228450 hasAuthorship W1936228450A5085300062 @default.
• W1936228450 hasBestOaLocation W19362284501 @default.
• W1936228450 hasConcept C126322002 @default.
• W1936228450 hasConcept C134018914 @default.
• W1936228450 hasConcept C193230392 @default.
• W1936228450 hasConcept C2776580952 @default.
• W1936228450 hasConcept C2776706248 @default.
• W1936228450 hasConcept C2777214474 @default.
• W1936228450 hasConcept C2777391703 @default.
• W1936228450 hasConcept C2777992278 @default.
• W1936228450 hasConcept C2778345441 @default.
• W1936228450 hasConcept C2778563252 @default.
• W1936228450 hasConcept C2779306644 @default.
• W1936228450 hasConcept C2779572773 @default.
• W1936228450 hasConcept C2780677274 @default.
• W1936228450 hasConcept C515207424 @default.
• W1936228450 hasConcept C55493867 @default.
• W1936228450 hasConcept C62231903 @default.
• W1936228450 hasConcept C71924100 @default.
• W1936228450 hasConcept C86803240 @default.
• W1936228450 hasConceptScore W1936228450C126322002 @default.
• W1936228450 hasConceptScore W1936228450C134018914 @default.
• W1936228450 hasConceptScore W1936228450C193230392 @default.
• W1936228450 hasConceptScore W1936228450C2776580952 @default.
• W1936228450 hasConceptScore W1936228450C2776706248 @default.
• W1936228450 hasConceptScore W1936228450C2777214474 @default.
• W1936228450 hasConceptScore W1936228450C2777391703 @default.
• W1936228450 hasConceptScore W1936228450C2777992278 @default.
• W1936228450 hasConceptScore W1936228450C2778345441 @default.
• W1936228450 hasConceptScore W1936228450C2778563252 @default.
• W1936228450 hasConceptScore W1936228450C2779306644 @default.
• W1936228450 hasConceptScore W1936228450C2779572773 @default.
• W1936228450 hasConceptScore W1936228450C2780677274 @default.
• W1936228450 hasConceptScore W1936228450C515207424 @default.
• W1936228450 hasConceptScore W1936228450C55493867 @default.
• W1936228450 hasConceptScore W1936228450C62231903 @default.
• W1936228450 hasConceptScore W1936228450C71924100 @default.
• W1936228450 hasConceptScore W1936228450C86803240 @default.
• W1936228450 hasIssue "2" @default.
• W1936228450 hasLocation W19362284501 @default.

• next