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• W1936256720 startingPage "1098" @default.
• W1936256720 abstract "Histone deacetylase (HDAC) proteins, which counter the activity of histone acetyltransferases (HATs), are necessary for normal muscle atrophy in response to several pathophysiological conditions. Despite this, it remains unknown whether a common or unique transcriptional profile of HDAC and HAT genes exist during the progression of muscle atrophy.Muscles were harvested from cast immobilized, denervated, or nutrient deprived animals for quantitative reverse transcriptase-polymerase chain reaction analysis of HDAC and HAT gene expression.The mRNA levels of Hdac2, Hdac4, Hdac6, Sirt1, p300, Cbp, and Pcaf increased, and Hdac7 decreased in skeletal muscle in each experimental model of muscle atrophy. Hdac1 and Hdac3 were increased only in cast immobilized and denervated muscles.While specific HDACs and HATs are increased in multiple models of muscle atrophy, increased expression of class I HDACs was unique to muscle disuse, reinforcing that specific HDAC inhibitors may be more effective than pan-HDAC inhibitors at countering muscle atrophy." @default.
• W1936256720 created "2016-06-24" @default.
• W1936256720 creator A5060957121 @default.
• W1936256720 creator A5084077383 @default.
• W1936256720 date "2015-10-10" @default.
• W1936256720 modified "2023-10-16" @default.
• W1936256720 title "Differential expression of<i>HDAC</i>and<i>HAT</i>genes in atrophying skeletal muscle" @default.
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• W1936256720 doi "https://doi.org/10.1002/mus.24912" @default.
• W1936256720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4715560" @default.
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• W1936256720 hasPublicationYear "2015" @default.
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