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- W1936322262 startingPage "167" @default.
- W1936322262 abstract "Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor involved in the control of metabolism. Research on PPARgamma is oriented towards understanding its role in insulin sensitization, which was inspired by the discovery that antidiabetic agents, the thiazolidinediones, were agonists for PPARgamma. PPARgamma stimulation improves glucose tolerance and insulin sensitivity in type 2 diabetic patients and in animal models of insulin resistance through mechanisms that are incompletely understood. Upon activation, PPARgamma heterodimerizes with retinoid X receptor, recruits specific cofactors, and binds to responsive DNA elements, thereby stimulating the transcription of target genes. Because PPARgamma is highly enriched in adipose tissue and because of its major role in adipocyte differentiation, it is thought that the effects of PPARgamma in adipose tissue are crucial to explain its role in insulin sensitization, but recent studies have highlighted the contribution of other tissues as well. Although relatively potent for their insulin-sensitizing action, currently marketed PPARgamma activators have some important undesirable side effects. These concerns led to the discovery of new ligands with potent antidiabetic properties but devoid of certain of these side effects. Data from human genetic studies and from PPARgamma heterozygous knockout mice indicate that a reduction in PPARgamma activity could paradoxically improve insulin sensitivity. These findings suggest that modulation of PPARgamma activity by partial agonists or compounds that affect cofactor recruitment might hold promise for the treatment of insulin resistance." @default.
- W1936322262 created "2016-06-24" @default.
- W1936322262 creator A5003154600 @default.
- W1936322262 creator A5068770639 @default.
- W1936322262 date "2002-07-01" @default.
- W1936322262 modified "2023-10-11" @default.
- W1936322262 title "PPARγ<scp>AND</scp>G<scp>LUCOSE</scp>H<scp>OMEOSTASIS</scp>" @default.
- W1936322262 cites W1488559297 @default.
- W1936322262 cites W149212049 @default.
- W1936322262 cites W1493268813 @default.
- W1936322262 cites W1494780959 @default.
- W1936322262 cites W1501286679 @default.
- W1936322262 cites W1501509481 @default.
- W1936322262 cites W1524321743 @default.
- W1936322262 cites W1527649416 @default.
- W1936322262 cites W1527827101 @default.
- W1936322262 cites W1580569338 @default.
- W1936322262 cites W1587875569 @default.
- W1936322262 cites W1672804368 @default.
- W1936322262 cites W1675830194 @default.
- W1936322262 cites W1764140709 @default.
- W1936322262 cites W1843523988 @default.
- W1936322262 cites W1917585691 @default.
- W1936322262 cites W1951826532 @default.
- W1936322262 cites W1964416938 @default.
- W1936322262 cites W1965240451 @default.
- W1936322262 cites W1967501975 @default.
- W1936322262 cites W1967869803 @default.
- W1936322262 cites W1968237817 @default.
- W1936322262 cites W1968703258 @default.
- W1936322262 cites W1969161886 @default.
- W1936322262 cites W1969437387 @default.
- W1936322262 cites W1970474244 @default.
- W1936322262 cites W1970599568 @default.
- W1936322262 cites W1971473302 @default.
- W1936322262 cites W1972220181 @default.
- W1936322262 cites W1975561886 @default.
- W1936322262 cites W1975927677 @default.
- W1936322262 cites W1977554203 @default.
- W1936322262 cites W1979892446 @default.
- W1936322262 cites W1981261500 @default.
- W1936322262 cites W1985735647 @default.
- W1936322262 cites W1986050686 @default.
- W1936322262 cites W1986219421 @default.
- W1936322262 cites W1986256219 @default.
- W1936322262 cites W1987052134 @default.
- W1936322262 cites W1987467897 @default.
- W1936322262 cites W1987652896 @default.
- W1936322262 cites W1987692887 @default.
- W1936322262 cites W1989674865 @default.
- W1936322262 cites W1992968076 @default.
- W1936322262 cites W1994489610 @default.
- W1936322262 cites W1995398218 @default.
- W1936322262 cites W1996499493 @default.
- W1936322262 cites W1997130090 @default.
- W1936322262 cites W1999143122 @default.
- W1936322262 cites W1999236387 @default.
- W1936322262 cites W1999571240 @default.
- W1936322262 cites W1999898110 @default.
- W1936322262 cites W2001470299 @default.
- W1936322262 cites W2001742702 @default.
- W1936322262 cites W2002519246 @default.
- W1936322262 cites W2003420643 @default.
- W1936322262 cites W2003856834 @default.
- W1936322262 cites W2005674716 @default.
- W1936322262 cites W2006918309 @default.
- W1936322262 cites W2007888714 @default.
- W1936322262 cites W2008632158 @default.
- W1936322262 cites W2011246715 @default.
- W1936322262 cites W2014093920 @default.
- W1936322262 cites W2019570781 @default.
- W1936322262 cites W2020865621 @default.
- W1936322262 cites W2021520674 @default.
- W1936322262 cites W2022110250 @default.
- W1936322262 cites W2024254257 @default.
- W1936322262 cites W2024682491 @default.
- W1936322262 cites W2027138424 @default.
- W1936322262 cites W2027360957 @default.
- W1936322262 cites W2027832656 @default.
- W1936322262 cites W2027874598 @default.
- W1936322262 cites W2028661874 @default.
- W1936322262 cites W2029410945 @default.
- W1936322262 cites W2031695379 @default.
- W1936322262 cites W2033125833 @default.
- W1936322262 cites W2033752591 @default.
- W1936322262 cites W2035458523 @default.
- W1936322262 cites W2037073171 @default.
- W1936322262 cites W2037094605 @default.
- W1936322262 cites W2037282294 @default.
- W1936322262 cites W2039937531 @default.
- W1936322262 cites W2040671595 @default.
- W1936322262 cites W2042618169 @default.
- W1936322262 cites W2042669405 @default.
- W1936322262 cites W2042694949 @default.
- W1936322262 cites W2045303501 @default.
- W1936322262 cites W2045319638 @default.
- W1936322262 cites W2045337533 @default.
- W1936322262 cites W2045649324 @default.