FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1936409022> ?p ?o ?g. }

• W1936409022 endingPage "6603" @default.
• W1936409022 startingPage "6596" @default.
• W1936409022 abstract "IL-23 is a heterodimeric cytokine composed of a unique p19 subunit and a common p40 subunit is shared with IL-12. IL-23 promotes the inflammatory response by inducing the expansion of CD4(+) cells producing IL-17. The regulation of p19 gene expression has been less studied than that of p40 subunit expression, which in macrophages is well known to be dependent on NF-kappaB. To clarify the role of NF-kappaB in expression of the p19 gene, we analyzed mRNA levels in NF-kappaB-deficient macrophages. As reported to occur in dendritic cells, p19 expression was dramatically reduced in c-rel-deficient macrophages. Moreover, we found that p19 expression was halved in rela-deficient macrophages, but it was enhanced in p52-deficient macrophages. The p19 promoter contains three putative kappaB sites, located at nt -642 to -632 (kappaB-642), nt -513 to -503 (kappaB-513), and nt -105 to -96 (kappaB-105), between the transcription start site and -937 bp upstream in the p19 promoter region. Although EMSA analysis indicated that both kappaB-105 and kappaB-642, but not kappaB-513, bound to NF-kappaB in vitro, luciferase-based reporter assays showed that the most proximal kappaB site, kappaB-105, was uniquely indispensable to the induction of p19 transcription. Chromatin immunoprecipitation demonstrated in vivo association of RelA, c-Rel, and p50 with kappaB-105 of the p19 promoter. These results provide the evidence that the association of RelA and c-Rel with the proximal kappaB site in the p19 promoter is required to induce of p19 expression." @default.
• W1936409022 created "2016-06-24" @default.
• W1936409022 creator A5029922212 @default.
• W1936409022 creator A5049678731 @default.
• W1936409022 creator A5051079614 @default.
• W1936409022 creator A5057735595 @default.
• W1936409022 creator A5073630542 @default.
• W1936409022 creator A5080875747 @default.
• W1936409022 date "2007-11-15" @default.
• W1936409022 modified "2023-09-23" @default.
• W1936409022 title "A Proximal κB Site in the IL-23 p19 Promoter Is Responsible for RelA- and c-Rel-Dependent Transcription" @default.
• W1936409022 cites W1480238487 @default.
• W1936409022 cites W1545719335 @default.
• W1936409022 cites W1583940016 @default.
• W1936409022 cites W1592326302 @default.
• W1936409022 cites W1603650405 @default.
• W1936409022 cites W1671478536 @default.
• W1936409022 cites W1847326477 @default.
• W1936409022 cites W1929136736 @default.
• W1936409022 cites W1965471441 @default.
• W1936409022 cites W1968918322 @default.
• W1936409022 cites W1974162725 @default.
• W1936409022 cites W1976775782 @default.
• W1936409022 cites W1978368004 @default.
• W1936409022 cites W1987628377 @default.
• W1936409022 cites W2003252110 @default.
• W1936409022 cites W2006249161 @default.
• W1936409022 cites W2009219530 @default.
• W1936409022 cites W2031375858 @default.
• W1936409022 cites W2034611241 @default.
• W1936409022 cites W2035027025 @default.
• W1936409022 cites W2042166751 @default.
• W1936409022 cites W2052411313 @default.
• W1936409022 cites W2063512271 @default.
• W1936409022 cites W2070910474 @default.
• W1936409022 cites W2075555955 @default.
• W1936409022 cites W2076889715 @default.
• W1936409022 cites W2087122540 @default.
• W1936409022 cites W2087905758 @default.
• W1936409022 cites W2090197666 @default.
• W1936409022 cites W2098586771 @default.
• W1936409022 cites W2098710866 @default.
• W1936409022 cites W2101385118 @default.
• W1936409022 cites W2107235439 @default.
• W1936409022 cites W2107664859 @default.
• W1936409022 cites W2116537360 @default.
• W1936409022 cites W2116828514 @default.
• W1936409022 cites W2130933356 @default.
• W1936409022 cites W2133872922 @default.
• W1936409022 cites W2135218342 @default.
• W1936409022 cites W2146336227 @default.
• W1936409022 cites W2150038520 @default.
• W1936409022 cites W2151625863 @default.
• W1936409022 cites W2159546356 @default.
• W1936409022 cites W4243182832 @default.
• W1936409022 doi "https://doi.org/10.4049/jimmunol.179.10.6596" @default.
• W1936409022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17982049" @default.
• W1936409022 hasPublicationYear "2007" @default.
• W1936409022 type Work @default.
• W1936409022 sameAs 1936409022 @default.
• W1936409022 citedByCount "84" @default.
• W1936409022 countsByYear W19364090222012 @default.
• W1936409022 countsByYear W19364090222013 @default.
• W1936409022 countsByYear W19364090222014 @default.
• W1936409022 countsByYear W19364090222015 @default.
• W1936409022 countsByYear W19364090222016 @default.
• W1936409022 countsByYear W19364090222017 @default.
• W1936409022 countsByYear W19364090222019 @default.
• W1936409022 countsByYear W19364090222020 @default.
• W1936409022 countsByYear W19364090222021 @default.
• W1936409022 crossrefType "journal-article" @default.
• W1936409022 hasAuthorship W1936409022A5029922212 @default.
• W1936409022 hasAuthorship W1936409022A5049678731 @default.
• W1936409022 hasAuthorship W1936409022A5051079614 @default.
• W1936409022 hasAuthorship W1936409022A5057735595 @default.
• W1936409022 hasAuthorship W1936409022A5073630542 @default.
• W1936409022 hasAuthorship W1936409022A5080875747 @default.
• W1936409022 hasBestOaLocation W19364090221 @default.
• W1936409022 hasConcept C101762097 @default.
• W1936409022 hasConcept C104292427 @default.
• W1936409022 hasConcept C104317684 @default.
• W1936409022 hasConcept C134320426 @default.
• W1936409022 hasConcept C138885662 @default.
• W1936409022 hasConcept C148738053 @default.
• W1936409022 hasConcept C150194340 @default.
• W1936409022 hasConcept C153911025 @default.
• W1936409022 hasConcept C179926584 @default.
• W1936409022 hasConcept C20875687 @default.
• W1936409022 hasConcept C26805974 @default.
• W1936409022 hasConcept C41895202 @default.
• W1936409022 hasConcept C54355233 @default.
• W1936409022 hasConcept C86339819 @default.
• W1936409022 hasConcept C86803240 @default.
• W1936409022 hasConcept C95444343 @default.
• W1936409022 hasConceptScore W1936409022C101762097 @default.
• W1936409022 hasConceptScore W1936409022C104292427 @default.
• W1936409022 hasConceptScore W1936409022C104317684 @default.
• W1936409022 hasConceptScore W1936409022C134320426 @default.

• next