FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1936498642> ?p ?o ?g. }

• W1936498642 endingPage "264" @default.
• W1936498642 startingPage "253" @default.
• W1936498642 abstract "Melatonin, an endogenously produced neurohormone secreted mainly by the pineal gland, has a variety of physiological functions and neuroprotective effects. Saturated fatty acids (SFAs) have been known to induce neurotoxicity and oxidative stress in central nervous system injuries and neurodegenerative pathologies. However, the effect of melatonin on SFAs-induced cytotoxicity in astroglial cells, if any, has remained to be explored. This study reports that in primary cultured astroglial cells, melatonin significantly attenuated palmitic acid (PA)-induced cytotoxicity in a concentration- and time-dependent manner. Additionally, melatonin effectively suppressed PA-induced reactive oxygen species generation and prevented PA-induced apoptosis whereby the rise in Bax/Bcl-2 ratio and caspase-3 activation in astroglial cells was inhibited. However, it did not appear to exert an obvious effect on PA-induced intracellular calcium overload. Luzindole, a nonselective melatonin receptor antagonist, attenuated melatonin's promotion effect of cell survival and Stat3 phosphorylation, indicating that melatonin exerts its protective property in astroglial cells, at least in part, through the activation of membrane receptors and then Stat3 signaling pathway. Finally, melatonin had an inhibitory effect on the pro-inflammatory cytokine gene expression. The results suggest that melatonin may be an effective cytoprotective agent against PA-based cytotoxicity through modulating cell survival and inflammatory response in astroglial cells." @default.
• W1936498642 created "2016-06-24" @default.
• W1936498642 creator A5004957511 @default.
• W1936498642 creator A5006427778 @default.
• W1936498642 creator A5017252015 @default.
• W1936498642 creator A5053942124 @default.
• W1936498642 creator A5065058975 @default.
• W1936498642 creator A5065883596 @default.
• W1936498642 creator A5068074713 @default.
• W1936498642 date "2011-09-19" @default.
• W1936498642 modified "2023-10-18" @default.
• W1936498642 title "Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro" @default.
• W1936498642 cites W1604006656 @default.
• W1936498642 cites W1868989971 @default.
• W1936498642 cites W1964130521 @default.
• W1936498642 cites W1964724896 @default.
• W1936498642 cites W1965942744 @default.
• W1936498642 cites W1966230375 @default.
• W1936498642 cites W1966357480 @default.
• W1936498642 cites W1972095168 @default.
• W1936498642 cites W1987388371 @default.
• W1936498642 cites W2008774076 @default.
• W1936498642 cites W2015308396 @default.
• W1936498642 cites W2017560509 @default.
• W1936498642 cites W2024728491 @default.
• W1936498642 cites W2026313159 @default.
• W1936498642 cites W2040232546 @default.
• W1936498642 cites W2059177685 @default.
• W1936498642 cites W2059479689 @default.
• W1936498642 cites W2065738132 @default.
• W1936498642 cites W2067298193 @default.
• W1936498642 cites W2067609140 @default.
• W1936498642 cites W2074661552 @default.
• W1936498642 cites W2079320514 @default.
• W1936498642 cites W2083666530 @default.
• W1936498642 cites W2086950281 @default.
• W1936498642 cites W2087496358 @default.
• W1936498642 cites W2088926054 @default.
• W1936498642 cites W2090465196 @default.
• W1936498642 cites W2091619548 @default.
• W1936498642 cites W2097767970 @default.
• W1936498642 cites W2113846183 @default.
• W1936498642 cites W2120959739 @default.
• W1936498642 cites W2122007084 @default.
• W1936498642 cites W2127236047 @default.
• W1936498642 cites W2127303641 @default.
• W1936498642 cites W2132534755 @default.
• W1936498642 cites W2136350449 @default.
• W1936498642 cites W2138193003 @default.
• W1936498642 cites W2143533829 @default.
• W1936498642 cites W2146845170 @default.
• W1936498642 cites W2148552685 @default.
• W1936498642 cites W2155856211 @default.
• W1936498642 cites W2171988255 @default.
• W1936498642 cites W2323516874 @default.
• W1936498642 cites W4236538876 @default.
• W1936498642 cites W4240479615 @default.
• W1936498642 cites W4254794606 @default.
• W1936498642 cites W4255760236 @default.
• W1936498642 doi "https://doi.org/10.1111/j.1600-079x.2011.00952.x" @default.
• W1936498642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21929682" @default.
• W1936498642 hasPublicationYear "2011" @default.
• W1936498642 type Work @default.
• W1936498642 sameAs 1936498642 @default.
• W1936498642 citedByCount "40" @default.
• W1936498642 countsByYear W19364986422012 @default.
• W1936498642 countsByYear W19364986422013 @default.
• W1936498642 countsByYear W19364986422014 @default.
• W1936498642 countsByYear W19364986422015 @default.
• W1936498642 countsByYear W19364986422016 @default.
• W1936498642 countsByYear W19364986422017 @default.
• W1936498642 countsByYear W19364986422018 @default.
• W1936498642 countsByYear W19364986422019 @default.
• W1936498642 countsByYear W19364986422020 @default.
• W1936498642 countsByYear W19364986422021 @default.
• W1936498642 countsByYear W19364986422022 @default.
• W1936498642 crossrefType "journal-article" @default.
• W1936498642 hasAuthorship W1936498642A5004957511 @default.
• W1936498642 hasAuthorship W1936498642A5006427778 @default.
• W1936498642 hasAuthorship W1936498642A5017252015 @default.
• W1936498642 hasAuthorship W1936498642A5053942124 @default.
• W1936498642 hasAuthorship W1936498642A5065058975 @default.
• W1936498642 hasAuthorship W1936498642A5065883596 @default.
• W1936498642 hasAuthorship W1936498642A5068074713 @default.
• W1936498642 hasConcept C109316439 @default.
• W1936498642 hasConcept C126322002 @default.
• W1936498642 hasConcept C134018914 @default.
• W1936498642 hasConcept C170493617 @default.
• W1936498642 hasConcept C185592680 @default.
• W1936498642 hasConcept C190283241 @default.
• W1936498642 hasConcept C202751555 @default.
• W1936498642 hasConcept C25498285 @default.
• W1936498642 hasConcept C2776151105 @default.
• W1936498642 hasConcept C2778182776 @default.
• W1936498642 hasConcept C2779491297 @default.
• W1936498642 hasConcept C2780059843 @default.
• W1936498642 hasConcept C2781269140 @default.
• W1936498642 hasConcept C2781416619 @default.

• next