FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1936576945> ?p ?o ?g. }

• W1936576945 endingPage "334" @default.
• W1936576945 startingPage "329" @default.
• W1936576945 abstract "CD4+CD25+ regulatory T cells (TRegs) are critical for the acquisition of peripheral allograft tolerance. However, it is unclear whether TRegs are capable of mediating alloantigen-specific suppressive effects and, hence, contributing to the specificity of the tolerant state. In the current report we have used the ABM TCR transgenic (Tg) system, a C57BL/6-derived strain in which CD4+ T cells directly recognize the allogeneic MHC-II molecule I-A(bm12), to assess the capacity of TRegs to mediate allospecific effects. In these mice, 5-6% of Tg CD4+ T cells exhibit conventional markers of the TReg phenotype. ABM TRegs are more effective than wild-type polyclonal TRegs at suppressing effector immune responses directed against I-A(bm12) alloantigen both in vitro and in vivo. In contrast, they are incapable of suppressing responses directed against third-party alloantigens unless these are expressed in the same allograft as I-A(bm12). Taken together, our results indicate that in transplantation, TReg function is dependent on TCR stimulation, providing definitive evidence for their specificity in the regulation of alloimmune responses." @default.
• W1936576945 created "2016-06-24" @default.
• W1936576945 creator A5028211848 @default.
• W1936576945 creator A5035207277 @default.
• W1936576945 creator A5037597028 @default.
• W1936576945 creator A5054858357 @default.
• W1936576945 creator A5060724793 @default.
• W1936576945 creator A5069765168 @default.
• W1936576945 creator A5076258810 @default.
• W1936576945 creator A5076282121 @default.
• W1936576945 creator A5077088242 @default.
• W1936576945 creator A5081532245 @default.
• W1936576945 date "2006-01-01" @default.
• W1936576945 modified "2023-10-18" @default.
• W1936576945 title "Specificity of CD4+CD25+ Regulatory T Cell Function in Alloimmunity" @default.
• W1936576945 cites W1509909867 @default.
• W1936576945 cites W1572998682 @default.
• W1936576945 cites W1895002782 @default.
• W1936576945 cites W1920762003 @default.
• W1936576945 cites W1946569686 @default.
• W1936576945 cites W1967942756 @default.
• W1936576945 cites W1974535482 @default.
• W1936576945 cites W1995368448 @default.
• W1936576945 cites W2000084820 @default.
• W1936576945 cites W2019246216 @default.
• W1936576945 cites W2021428880 @default.
• W1936576945 cites W2024351056 @default.
• W1936576945 cites W2030416301 @default.
• W1936576945 cites W2067648924 @default.
• W1936576945 cites W2068238618 @default.
• W1936576945 cites W2076434196 @default.
• W1936576945 cites W2083629532 @default.
• W1936576945 cites W2099318980 @default.
• W1936576945 cites W2107113286 @default.
• W1936576945 cites W2114412297 @default.
• W1936576945 cites W2122262578 @default.
• W1936576945 cites W2125311191 @default.
• W1936576945 cites W2129767277 @default.
• W1936576945 cites W2132427916 @default.
• W1936576945 cites W2135336115 @default.
• W1936576945 cites W2138307745 @default.
• W1936576945 cites W2150453791 @default.
• W1936576945 cites W2152561959 @default.
• W1936576945 cites W2161719887 @default.
• W1936576945 cites W2169233545 @default.
• W1936576945 cites W2172223853 @default.
• W1936576945 cites W2792966232 @default.
• W1936576945 doi "https://doi.org/10.4049/jimmunol.176.1.329" @default.
• W1936576945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2841032" @default.
• W1936576945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16365425" @default.
• W1936576945 hasPublicationYear "2006" @default.
• W1936576945 type Work @default.
• W1936576945 sameAs 1936576945 @default.
• W1936576945 citedByCount "116" @default.
• W1936576945 countsByYear W19365769452012 @default.
• W1936576945 countsByYear W19365769452013 @default.
• W1936576945 countsByYear W19365769452014 @default.
• W1936576945 countsByYear W19365769452015 @default.
• W1936576945 countsByYear W19365769452016 @default.
• W1936576945 countsByYear W19365769452017 @default.
• W1936576945 countsByYear W19365769452018 @default.
• W1936576945 countsByYear W19365769452019 @default.
• W1936576945 countsByYear W19365769452020 @default.
• W1936576945 countsByYear W19365769452021 @default.
• W1936576945 countsByYear W19365769452022 @default.
• W1936576945 countsByYear W19365769452023 @default.
• W1936576945 crossrefType "journal-article" @default.
• W1936576945 hasAuthorship W1936576945A5028211848 @default.
• W1936576945 hasAuthorship W1936576945A5035207277 @default.
• W1936576945 hasAuthorship W1936576945A5037597028 @default.
• W1936576945 hasAuthorship W1936576945A5054858357 @default.
• W1936576945 hasAuthorship W1936576945A5060724793 @default.
• W1936576945 hasAuthorship W1936576945A5069765168 @default.
• W1936576945 hasAuthorship W1936576945A5076258810 @default.
• W1936576945 hasAuthorship W1936576945A5076282121 @default.
• W1936576945 hasAuthorship W1936576945A5077088242 @default.
• W1936576945 hasAuthorship W1936576945A5081532245 @default.
• W1936576945 hasBestOaLocation W19365769451 @default.
• W1936576945 hasConcept C102230213 @default.
• W1936576945 hasConcept C104317684 @default.
• W1936576945 hasConcept C141071460 @default.
• W1936576945 hasConcept C19317047 @default.
• W1936576945 hasConcept C203014093 @default.
• W1936576945 hasConcept C207936829 @default.
• W1936576945 hasConcept C2776090121 @default.
• W1936576945 hasConcept C2777016536 @default.
• W1936576945 hasConcept C2777702733 @default.
• W1936576945 hasConcept C2778324207 @default.
• W1936576945 hasConcept C2911091166 @default.
• W1936576945 hasConcept C51785407 @default.
• W1936576945 hasConcept C54355233 @default.
• W1936576945 hasConcept C71924100 @default.
• W1936576945 hasConcept C79484868 @default.
• W1936576945 hasConcept C86803240 @default.
• W1936576945 hasConcept C8891405 @default.
• W1936576945 hasConcept C95444343 @default.
• W1936576945 hasConceptScore W1936576945C102230213 @default.
• W1936576945 hasConceptScore W1936576945C104317684 @default.

• next