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• W1936693061 startingPage "133" @default.
• W1936693061 abstract "Soil species, such as earthworms, potworms, springtails and to a lesser extent, carabids, molluscs and oribatid and predator mites are widely used to assess the toxicity of soil pollutants in academic and regulatory contexts. A recent extension of this work has been to provide a mechanistic component to these studies. Initially, terrestrial ecotoxicogenomic studies used the nematode Caenorhabditis elegans (Maupas). This was simply because it was the first soil-dwelling species for which the required tools for detailed study (principally sequence information) were available. Latterly, sufficient sequencing information to allow routine assessment of the expression of individual genes/proteins and the production of custom cDNA microarrays has become available for species such as the earthworms Lumbricus rubellus (Hoffmeister), Eisenia fetida (Savigny), the potworm Enchytraeus albidus (Henle), and springtails Orchesella cincta (Linnaeus) and Folsomia candida (Willem). Initial transcriptomic studies with such species have confirmed the sensitivity of gene expression as an endpoint for chemical exposure and its value for identifying the mechanism of toxic effects. Combined with the development of methods for proteomics and metabolomics this means that it is now feasible to use soil invertebrates in studies that can advance fundamental knowledge of important aspects of ecotoxicology, such as the biochemical basis of species sensitivity, the prevalence of multiple (and unexpected) modes of action, the basis and consequences of chemical-induced change at the population and community level, and deriving better understanding of the combined effects of pollutants." @default.
• W1936693061 created "2016-06-24" @default.
• W1936693061 creator A5039479556 @default.
• W1936693061 creator A5045775404 @default.
• W1936693061 creator A5084390618 @default.
• W1936693061 date "2008-01-01" @default.
• W1936693061 modified "2023-10-16" @default.
• W1936693061 title "Current research in soil invertebrate ecotoxicogenomics" @default.
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