FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1936698101> ?p ?o ?g. }

• W1936698101 endingPage "2442" @default.
• W1936698101 startingPage "2434" @default.
• W1936698101 abstract "The glial cell specificity of the human papovavirus JC (JCV), an etiologic agent for progressive multifocal leukoencephalopathy, is thought to be due to the presence of both positive and negative regulatory elements upstream of the TATA region within the JCV promoter. Here we report that the JCV minimal core promoter, containing only the TATA box and an 8-bp poly(T) region immediately upstream, is sufficient to initiate transcription of an attached gene in glial cells and functions as an autonomously active initiator. We further define the sequences required for this core promoter's glial cell specificity by appropriate substitution and point mutation analysis. Ectopic expression of Tst-1, a POU domain transcription factor that has been implicated in the regulation of oligodendrocyte development, leads to higher activation of the JCV minimal core promoter in Tst-1-deficient glial cells than in non-glial HeLa cells. These results suggest a requirement for a glial cell coactivator(s) for the optimum activation of the JCV minimal core promoter by Tst-1. A discrete affinity of Tst-1 for the JCV core promoter (Kd, 1.4 x 10(-8) M) is also shown to be optimal for its promoter strength. Mutations within the core promoter that maintain this affinity for Tst-1 show maintenance of promoter strength, whereas mutants carrying a change that results in an increased affinity for Tst-1 show reduced transcriptional activity. These results suggest that moderate affinity of Tst-1 for the JCV TATA region may allow the interaction of some glial cell-specific coactivator(s) along with the basal transcription machinery to direct glial cell-specific transcription from the JCV core promoter." @default.
• W1936698101 created "2016-06-24" @default.
• W1936698101 creator A5007453499 @default.
• W1936698101 creator A5030373310 @default.
• W1936698101 creator A5043150824 @default.
• W1936698101 date "1995-04-01" @default.
• W1936698101 modified "2023-09-27" @default.
• W1936698101 title "The JC virus minimal core promoter is glial cell specific in vivo" @default.
• W1936698101 cites W1487399858 @default.
• W1936698101 cites W1567228660 @default.
• W1936698101 cites W1572259338 @default.
• W1936698101 cites W1585895474 @default.
• W1936698101 cites W1588891010 @default.
• W1936698101 cites W1590884773 @default.
• W1936698101 cites W1637340367 @default.
• W1936698101 cites W1645445167 @default.
• W1936698101 cites W1748131880 @default.
• W1936698101 cites W1906274041 @default.
• W1936698101 cites W1940558382 @default.
• W1936698101 cites W1943449996 @default.
• W1936698101 cites W1967446284 @default.
• W1936698101 cites W1969331585 @default.
• W1936698101 cites W1979485999 @default.
• W1936698101 cites W1992409941 @default.
• W1936698101 cites W1992993455 @default.
• W1936698101 cites W1993805569 @default.
• W1936698101 cites W2000402112 @default.
• W1936698101 cites W2014018169 @default.
• W1936698101 cites W2027985112 @default.
• W1936698101 cites W2030046231 @default.
• W1936698101 cites W2050547367 @default.
• W1936698101 cites W2051738169 @default.
• W1936698101 cites W2053572117 @default.
• W1936698101 cites W2058544070 @default.
• W1936698101 cites W2064366027 @default.
• W1936698101 cites W2077534308 @default.
• W1936698101 cites W2079977159 @default.
• W1936698101 cites W2082540988 @default.
• W1936698101 cites W2105233165 @default.
• W1936698101 cites W2129329466 @default.
• W1936698101 cites W2136205634 @default.
• W1936698101 cites W2170143371 @default.
• W1936698101 cites W2179812999 @default.
• W1936698101 cites W2507063106 @default.
• W1936698101 cites W302659757 @default.
• W1936698101 cites W65487349 @default.
• W1936698101 doi "https://doi.org/10.1128/jvi.69.4.2434-2442.1995" @default.
• W1936698101 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/188918" @default.
• W1936698101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7884891" @default.
• W1936698101 hasPublicationYear "1995" @default.
• W1936698101 type Work @default.
• W1936698101 sameAs 1936698101 @default.
• W1936698101 citedByCount "25" @default.
• W1936698101 countsByYear W19366981012012 @default.
• W1936698101 countsByYear W19366981012013 @default.
• W1936698101 countsByYear W19366981012014 @default.
• W1936698101 countsByYear W19366981012016 @default.
• W1936698101 crossrefType "journal-article" @default.
• W1936698101 hasAuthorship W1936698101A5007453499 @default.
• W1936698101 hasAuthorship W1936698101A5030373310 @default.
• W1936698101 hasAuthorship W1936698101A5043150824 @default.
• W1936698101 hasBestOaLocation W19366981011 @default.
• W1936698101 hasConcept C101762097 @default.
• W1936698101 hasConcept C104317684 @default.
• W1936698101 hasConcept C138885662 @default.
• W1936698101 hasConcept C150194340 @default.
• W1936698101 hasConcept C153911025 @default.
• W1936698101 hasConcept C179926584 @default.
• W1936698101 hasConcept C41895202 @default.
• W1936698101 hasConcept C54355233 @default.
• W1936698101 hasConcept C65888428 @default.
• W1936698101 hasConcept C86339819 @default.
• W1936698101 hasConcept C86803240 @default.
• W1936698101 hasConceptScore W1936698101C101762097 @default.
• W1936698101 hasConceptScore W1936698101C104317684 @default.
• W1936698101 hasConceptScore W1936698101C138885662 @default.
• W1936698101 hasConceptScore W1936698101C150194340 @default.
• W1936698101 hasConceptScore W1936698101C153911025 @default.
• W1936698101 hasConceptScore W1936698101C179926584 @default.
• W1936698101 hasConceptScore W1936698101C41895202 @default.
• W1936698101 hasConceptScore W1936698101C54355233 @default.
• W1936698101 hasConceptScore W1936698101C65888428 @default.
• W1936698101 hasConceptScore W1936698101C86339819 @default.
• W1936698101 hasConceptScore W1936698101C86803240 @default.
• W1936698101 hasIssue "4" @default.
• W1936698101 hasLocation W19366981011 @default.
• W1936698101 hasLocation W19366981012 @default.
• W1936698101 hasLocation W19366981013 @default.
• W1936698101 hasLocation W19366981014 @default.
• W1936698101 hasOpenAccess W1936698101 @default.
• W1936698101 hasPrimaryLocation W19366981011 @default.
• W1936698101 hasRelatedWork W1897425192 @default.
• W1936698101 hasRelatedWork W1964229112 @default.
• W1936698101 hasRelatedWork W1982887948 @default.
• W1936698101 hasRelatedWork W2015869564 @default.
• W1936698101 hasRelatedWork W2015958124 @default.
• W1936698101 hasRelatedWork W2048413265 @default.
• W1936698101 hasRelatedWork W2071228459 @default.

• next