FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1936722638> ?p ?o ?g. }

• W1936722638 endingPage "5964" @default.
• W1936722638 startingPage "5958" @default.
• W1936722638 abstract "1,1'-Dimethyl-4,4'-bipyridinium dichloride (methyl viologen; paraquat), an herbicide that causes depletion of NADPH and generates excessive reactive oxygen species (ROS) in vivo, has been used to screen for ROS-sensitive Drosophila mutants. One mutant so isolated, named quiver(1) (qvr(1)), has a leg-shaking phenotype. Mutants of the Shaker (Sh), Hyperkinetic (Hk), and ether a go-go (eag) genes, which encode different K(+) channel subunits that regulate the A-type K(+) current (I(A)) in different ways, exhibit leg shaking under ether anesthesia and have heightened metabolic rates and shortened life spans. We found that Sh, Hk, and eag mutant flies were all hypersensitive to paraquat. Double-mutant combinations among the three channel mutations and qvr(1) had drastically enhanced sensitivity to paraquat. Synaptic transmission at the larval neuromuscular junction was increased in the qvr(1) mutant to the level of Sh mutants. Similar to eag Sh double mutants, double mutants of eag and qvr(1) showed striking enhancement in synaptic transmission and a wings-down phenotype, the hallmarks of extreme hyperexcitability. Voltage-clamp experiments demonstrated that the qvr(1) mutation specifically disrupted the Sh-dependent I(A) current without altering the other currents [I(K), Ca(2+)-activated fast (I(CF)) and slow (I(CS)) currents, and I(Ca)] in larval muscles. Several deficiency strains of the qvr locus failed to complement qvr(1) and confirmed that ether-induced leg shaking, reduced I(A) current, and paraquat hypersensitivity map to the same locus. Our results suggest that the qvr gene may encode a novel K(+) channel-related polypeptide and indicate a strong link between a voltage-activated K(+) current and vulnerability to ROS." @default.
• W1936722638 created "2016-06-24" @default.
• W1936722638 creator A5010842750 @default.
• W1936722638 creator A5016252268 @default.
• W1936722638 creator A5026788324 @default.
• W1936722638 creator A5032174738 @default.
• W1936722638 creator A5068575502 @default.
• W1936722638 date "2000-08-15" @default.
• W1936722638 modified "2023-10-11" @default.
• W1936722638 title "A Novel Leg-Shaking <i>Drosophila</i> Mutant Defective in a Voltage-Gated K⁺ Current and Hypersensitive to Reactive Oxygen Species" @default.
• W1936722638 cites W1426123684 @default.
• W1936722638 cites W1514133201 @default.
• W1936722638 cites W1597030777 @default.
• W1936722638 cites W1622707836 @default.
• W1936722638 cites W1636002961 @default.
• W1936722638 cites W1636334135 @default.
• W1936722638 cites W1868495882 @default.
• W1936722638 cites W1904062914 @default.
• W1936722638 cites W1941436081 @default.
• W1936722638 cites W1947481567 @default.
• W1936722638 cites W1953050875 @default.
• W1936722638 cites W1959918077 @default.
• W1936722638 cites W1964692954 @default.
• W1936722638 cites W1964807138 @default.
• W1936722638 cites W196651220 @default.
• W1936722638 cites W1977912923 @default.
• W1936722638 cites W1977943570 @default.
• W1936722638 cites W1979449524 @default.
• W1936722638 cites W1981398931 @default.
• W1936722638 cites W1983271741 @default.
• W1936722638 cites W1987689933 @default.
• W1936722638 cites W1991587314 @default.
• W1936722638 cites W1992689843 @default.
• W1936722638 cites W1995312770 @default.
• W1936722638 cites W1998557470 @default.
• W1936722638 cites W2011921542 @default.
• W1936722638 cites W2012598794 @default.
• W1936722638 cites W2012787015 @default.
• W1936722638 cites W2014716943 @default.
• W1936722638 cites W2015031388 @default.
• W1936722638 cites W2018435113 @default.
• W1936722638 cites W2019079004 @default.
• W1936722638 cites W2022576548 @default.
• W1936722638 cites W2024495842 @default.
• W1936722638 cites W2029195952 @default.
• W1936722638 cites W2032601606 @default.
• W1936722638 cites W2037824698 @default.
• W1936722638 cites W2043867460 @default.
• W1936722638 cites W2044750341 @default.
• W1936722638 cites W2047423425 @default.
• W1936722638 cites W2050185244 @default.
• W1936722638 cites W2050357864 @default.
• W1936722638 cites W2050430863 @default.
• W1936722638 cites W2051219862 @default.
• W1936722638 cites W2055873198 @default.
• W1936722638 cites W2057577050 @default.
• W1936722638 cites W2059459913 @default.
• W1936722638 cites W2063362197 @default.
• W1936722638 cites W2064166298 @default.
• W1936722638 cites W2078186934 @default.
• W1936722638 cites W2085803950 @default.
• W1936722638 cites W2089926641 @default.
• W1936722638 cites W2092870831 @default.
• W1936722638 cites W2102036006 @default.
• W1936722638 cites W2114443210 @default.
• W1936722638 cites W2132593434 @default.
• W1936722638 cites W2157075055 @default.
• W1936722638 cites W2407074268 @default.
• W1936722638 cites W2411865887 @default.
• W1936722638 doi "https://doi.org/10.1523/jneurosci.20-16-05958.2000" @default.
• W1936722638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6772572" @default.
• W1936722638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10934243" @default.
• W1936722638 hasPublicationYear "2000" @default.
• W1936722638 type Work @default.
• W1936722638 sameAs 1936722638 @default.
• W1936722638 citedByCount "34" @default.
• W1936722638 countsByYear W19367226382012 @default.
• W1936722638 countsByYear W19367226382013 @default.
• W1936722638 countsByYear W19367226382014 @default.
• W1936722638 countsByYear W19367226382016 @default.
• W1936722638 countsByYear W19367226382017 @default.
• W1936722638 countsByYear W19367226382018 @default.
• W1936722638 countsByYear W19367226382021 @default.
• W1936722638 countsByYear W19367226382022 @default.
• W1936722638 countsByYear W19367226382023 @default.
• W1936722638 crossrefType "journal-article" @default.
• W1936722638 hasAuthorship W1936722638A5010842750 @default.
• W1936722638 hasAuthorship W1936722638A5016252268 @default.
• W1936722638 hasAuthorship W1936722638A5026788324 @default.
• W1936722638 hasAuthorship W1936722638A5032174738 @default.
• W1936722638 hasAuthorship W1936722638A5068575502 @default.
• W1936722638 hasBestOaLocation W19367226381 @default.
• W1936722638 hasConcept C104317684 @default.
• W1936722638 hasConcept C12554922 @default.
• W1936722638 hasConcept C143065580 @default.
• W1936722638 hasConcept C153911025 @default.
• W1936722638 hasConcept C170493617 @default.
• W1936722638 hasConcept C185592680 @default.

• next