Matches in SemOpenAlex for { <https://semopenalex.org/work/W1936781909> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1936781909 abstract "Abstract Context.—Patients with hyperplastic polyposis coli syndrome are thought to harbor precursor lesions of a proposed hyperplasia-carcinoma pathway in colorectal cancer, but morphologic recognition of such lesions remains difficult. Hypermethylation of the secreted Frizzled receptor protein 1 gene on chromosome 8p12 is one of the earliest molecular alterations in colorectal carcinogenesis, potentially disrupting the Wnt signaling cascade of cellular growth control. Objective.—To determine if hyperplastic polyps from patients with hyperplastic polyposis coli syndrome show a distinct immunohistochemical expression pattern for mismatch repair proteins and secreted Frizzled receptor protein 1 compared to their sporadic counterparts. Design.—Immunohistochemical studies (secreted Frizzled receptor protein 1, 3 mismatch repair proteins, and p53) were performed on 23 hyperplastic polyps, 6 synchronous colon cancers, and normal colonic mucosa from 6 patients with hyperplastic polyposis coli syndrome and were compared with studies of sporadic hyperplastic polyps obtained from 13 matched control subjects. Results.—The staining pattern for the mismatch repair proteins MLH-1, MSH-2, and MSH-6 did not differ between sporadic and syndromic hyperplastic polyps. In contrast, 52% of syndromic hyperplastic polyps showed a reproducible and distinct staining pattern for secreted Frizzled receptor protein 1 that was not seen in control specimens and that was associated with larger polyp size (P = .002) and location in the proximal colon (P = .01). Conclusions.—Some hyperplastic polyps from patients with hyperplastic polyposis coli syndrome show a secreted Frizzled receptor protein 1 immunophenotype that could indicate alterations of cellular growth control. These findings may help identify precursor lesions in the proposed hyperplasia-carcinoma pathway of colorectal carcinogenesis." @default.
- W1936781909 created "2016-06-24" @default.
- W1936781909 creator A5024511018 @default.
- W1936781909 creator A5042448145 @default.
- W1936781909 creator A5044234999 @default.
- W1936781909 creator A5045956450 @default.
- W1936781909 creator A5063518326 @default.
- W1936781909 creator A5070166993 @default.
- W1936781909 creator A5071909367 @default.
- W1936781909 creator A5071926823 @default.
- W1936781909 date "2004-09-01" @default.
- W1936781909 modified "2023-09-25" @default.
- W1936781909 title "Distinct Secreted Frizzled Receptor Protein 1 Staining Pattern in Patients With Hyperplastic Polyposis Coli Syndrome" @default.
- W1936781909 cites W1533555842 @default.
- W1936781909 cites W1985146880 @default.
- W1936781909 cites W1997665669 @default.
- W1936781909 cites W2001372468 @default.
- W1936781909 cites W2018448892 @default.
- W1936781909 cites W2019354420 @default.
- W1936781909 cites W2022065340 @default.
- W1936781909 cites W2029484950 @default.
- W1936781909 cites W2029843689 @default.
- W1936781909 cites W2046540595 @default.
- W1936781909 cites W2048005397 @default.
- W1936781909 cites W2048399566 @default.
- W1936781909 cites W2062913179 @default.
- W1936781909 cites W2066493176 @default.
- W1936781909 cites W2067973442 @default.
- W1936781909 cites W2084649822 @default.
- W1936781909 cites W2088379175 @default.
- W1936781909 cites W2094088791 @default.
- W1936781909 cites W2110221861 @default.
- W1936781909 cites W2119030852 @default.
- W1936781909 cites W2124896165 @default.
- W1936781909 cites W2127280898 @default.
- W1936781909 cites W2131102783 @default.
- W1936781909 cites W2142314313 @default.
- W1936781909 cites W2163830096 @default.
- W1936781909 cites W2166932692 @default.
- W1936781909 cites W2167638513 @default.
- W1936781909 cites W2170483087 @default.
- W1936781909 cites W2343432753 @default.
- W1936781909 cites W2399135247 @default.
- W1936781909 cites W624674342 @default.
- W1936781909 cites W2138882303 @default.
- W1936781909 doi "https://doi.org/10.5858/2004-128-967-dsfrps" @default.
- W1936781909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15335268" @default.
- W1936781909 hasPublicationYear "2004" @default.
- W1936781909 type Work @default.
- W1936781909 sameAs 1936781909 @default.
- W1936781909 citedByCount "6" @default.
- W1936781909 countsByYear W19367819092016 @default.
- W1936781909 crossrefType "journal-article" @default.
- W1936781909 hasAuthorship W1936781909A5024511018 @default.
- W1936781909 hasAuthorship W1936781909A5042448145 @default.
- W1936781909 hasAuthorship W1936781909A5044234999 @default.
- W1936781909 hasAuthorship W1936781909A5045956450 @default.
- W1936781909 hasAuthorship W1936781909A5063518326 @default.
- W1936781909 hasAuthorship W1936781909A5070166993 @default.
- W1936781909 hasAuthorship W1936781909A5071909367 @default.
- W1936781909 hasAuthorship W1936781909A5071926823 @default.
- W1936781909 hasConcept C107300179 @default.
- W1936781909 hasConcept C137620995 @default.
- W1936781909 hasConcept C142724271 @default.
- W1936781909 hasConcept C170493617 @default.
- W1936781909 hasConcept C502942594 @default.
- W1936781909 hasConcept C54355233 @default.
- W1936781909 hasConcept C62478195 @default.
- W1936781909 hasConcept C71924100 @default.
- W1936781909 hasConcept C74864618 @default.
- W1936781909 hasConcept C86803240 @default.
- W1936781909 hasConcept C89423630 @default.
- W1936781909 hasConceptScore W1936781909C107300179 @default.
- W1936781909 hasConceptScore W1936781909C137620995 @default.
- W1936781909 hasConceptScore W1936781909C142724271 @default.
- W1936781909 hasConceptScore W1936781909C170493617 @default.
- W1936781909 hasConceptScore W1936781909C502942594 @default.
- W1936781909 hasConceptScore W1936781909C54355233 @default.
- W1936781909 hasConceptScore W1936781909C62478195 @default.
- W1936781909 hasConceptScore W1936781909C71924100 @default.
- W1936781909 hasConceptScore W1936781909C74864618 @default.
- W1936781909 hasConceptScore W1936781909C86803240 @default.
- W1936781909 hasConceptScore W1936781909C89423630 @default.
- W1936781909 hasLocation W19367819091 @default.
- W1936781909 hasOpenAccess W1936781909 @default.
- W1936781909 hasPrimaryLocation W19367819091 @default.
- W1936781909 hasRelatedWork W1980644634 @default.
- W1936781909 hasRelatedWork W1990671646 @default.
- W1936781909 hasRelatedWork W1993847375 @default.
- W1936781909 hasRelatedWork W2019781712 @default.
- W1936781909 hasRelatedWork W2070047473 @default.
- W1936781909 hasRelatedWork W2075296350 @default.
- W1936781909 hasRelatedWork W2095167939 @default.
- W1936781909 hasRelatedWork W2298930097 @default.
- W1936781909 hasRelatedWork W2333741020 @default.
- W1936781909 hasRelatedWork W2782224317 @default.
- W1936781909 isParatext "false" @default.
- W1936781909 isRetracted "false" @default.
- W1936781909 magId "1936781909" @default.
- W1936781909 workType "article" @default.