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• W1936789375 abstract "Abstract To deepen our knowledge of the natural host response to pathogens, our team undertook an in vivo screen of mutagenized 129S1 mice with Salmonella Typhimurium. One mutation affecting Salmonella susceptibility was mapped to a region of 1.3 Mb on chromosome 6 that contains 15 protein-coding genes. A missense mutation was identified in the Usp18 (ubiquitin-specific peptidase 18) gene. This mutation results in an increased inflammatory response (IL-6, type 1 IFN) to Salmonella and LPS challenge while paradoxically reducing IFN-γ production during bacterial infection. Increased STAT1 phosphorylation correlated with impaired STAT4 phosphorylation, resulting in overwhelming IL-6 secretion but reduced IFN-γ production during infection. The reduced IFN-γ levels, along with the increased inflammation, rationalize the S. Typhimurium susceptibility in terms of increased bacterial load in target organs and cytokine-induced septic shock and death." @default.
• W1936789375 created "2016-06-24" @default.
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• W1936789375 date "2010-09-15" @default.
• W1936789375 modified "2023-09-28" @default.
• W1936789375 title "<i>N</i>-Ethyl-<i>N</i>-Nitrosourea–Induced Mutation in Ubiquitin-Specific Peptidase 18 Causes Hyperactivation of IFN-αβ Signaling and Suppresses STAT4-Induced IFN-γ Production, Resulting in Increased Susceptibility to <i>Salmonella</i> Typhimurium" @default.
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• W1936789375 doi "https://doi.org/10.4049/jimmunol.1000890" @default.
• W1936789375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3987673" @default.
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• W1936789375 hasPublicationYear "2010" @default.
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