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• W1937095587 endingPage "355" @default.
• W1937095587 startingPage "349" @default.
• W1937095587 abstract "Abstract The objective of this study was to quantify, in vivo, constitutive and tumor necrosis factor α (TNF-α)-enhanced expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in different tissues from healthy wild-type mice (C57BL/6) as well as interleukin-10 (IL-10)-deficient mice with and without active colitis. Using the dual radiolabel monoclonal antibody technique, we found substantial constitutive expression of MAdCAM-1 in the intestine, colon, and mesenteric lymph nodes. MAdCAM-1 expression in these tissues was significantly enhanced, in a time-dependent manner, by systemic administration of TNF-α. Maximum surface expression was observed at 18 h after TNF-α administration and remained significantly elevated at 48 h post-TNF-α injection. No significant constitutive nor TNF-α-induced expression of MAdCAM-1 was detected in skeletal muscle, brain, or heart. In IL-10-deficient (IL-10 k/o) mice with no clinical or histological evidence of colitis, constitutive and TNF-α-induced expression of MAdCAM-1 in the intestine, cecum, and colon was not different from those values obtained with healthy wild-type controls. IL-10-deficient mice with active colitis exhibited a four- to fivefold greater expression of MAdCAM-1 in the cecum and colon compared with their healthy controls or to IL-10 k/o mice with no evidence of colitis. Taken together, these data demonstrate that TNF-α enhances surface expression of MAdCAM-1 in intestinal and colonic tissues to the same extent in both wild-type and IL-10 k/o mice with no colonic inflammation, whereas IL-10 k/o mice with active colitis exhibited a profound up-regulation of MAd-CAM-1 in the colon. J. Leukoc. Biol. 65: 349–355; 1999." @default.
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• W1937095587 date "1999-03-01" @default.
• W1937095587 modified "2023-10-14" @default.
• W1937095587 title "Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation" @default.
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• W1937095587 doi "https://doi.org/10.1002/jlb.65.3.349" @default.
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