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• W1937108761 startingPage "777" @default.
• W1937108761 abstract "In the avian embryo, previous work has demonstrated that the notochord provides inductive signals to activate myoD and pax1 regulatory genes, which are expressed in the dorsal and ventral somite cells that give rise to myotomal and sclerotomal lineages. Here, we present bead implantation and antisense inhibition experiments that show that Sonic hedgehog is both a sufficient and essential notochord signal molecule for myoD and pax1 activation in somites. Furthermore, we show that genes of the Sonic hedgehog signal response pathway, specifically patched, the Sonic hedgehog receptor, and gli and gli2/4, zinc-finger transcription factors, are activated in coordination with somite formation, establishing that Sonic hedgehog response genes play a regulatory role in coordinating the response of somites to the constitutive notochord Sonic hedgehog signal. Furthermore, the expression of patched, gli and gli2/4 is differentially patterned in the somite, providing mechanisms for differentially transducing the Sonic hedgehog signal to the myotomal and sclerotomal lineages. Finally, we show that the activation of gli2/4 is controlled by the process of somite formation and signals from the surface ectoderm, whereas upregulation of patched and activation of gli is controlled by the process of somite formation and a Sonic hedgehog signal. The Sonic hedgehog signal response genes, therefore, have important functions in regulating the initiation of the Sonic hedgehog response in newly forming somites and in regulating the patterned expression of myoD and pax1 in the myotomal and sclerotomal lineages following somite formation." @default.
• W1937108761 created "2016-06-24" @default.
• W1937108761 creator A5025013689 @default.
• W1937108761 creator A5032220656 @default.
• W1937108761 creator A5061117950 @default.
• W1937108761 date "1998-02-15" @default.
• W1937108761 modified "2023-10-05" @default.
• W1937108761 title "Control of somite patterning by Sonic hedgehog and its downstream signal response genes" @default.
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• W1937108761 doi "https://doi.org/10.1242/dev.125.4.777" @default.
• W1937108761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9435297" @default.
• W1937108761 hasPublicationYear "1998" @default.
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