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- W19371337 abstract "The following topics are discussed: compartment model building (validation of the superposition principle, formulation of the model, analysis of its freedom's degrees, model solving by multiexponential function fitting, by direct solving method, by mapping); use of the Laplace transformation and of the directed graph; calculations on the graph; zero order reactions and the graph; large system analysis (division into subsystem, black box analysis, deconvolution, precursor-product relationship); effect of drugs on the transfer constants; kinetics of the effect and its inclusion in compartmental models; “system analysis” approach." @default.
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- W19371337 date "1970-01-01" @default.
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- W19371337 title "Use of Mathematical Tools in Defining Pharmacokinetic Parameters" @default.
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- W19371337 doi "https://doi.org/10.1016/b978-0-08-017548-5.50011-4" @default.
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