FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1937133798> ?p ?o ?g. }

• W1937133798 endingPage "1302" @default.
• W1937133798 startingPage "1294" @default.
• W1937133798 abstract "Persistent high-risk human papillomavirus (HPV) infection is strongly associated with the development of high-grade cervical intraepithelial neoplasia (CIN) or cancer. Not all persistent infections lead to cancer. Viral load measured at a single time-point is a poor predictor of the natural history of HPV infections. However the profile of viral load evolution over time could distinguish nonprogressive from progressive (carcinogenic) infections. A retrospective natural history study was set up using a Belgian laboratory database including more than 800,000 liquid cytology specimens. All samples were submitted to qPCR identifying E6/E7 genes of 18 HPV types. Viral load changes over time were assessed by the linear regression slope. Database search identified 261 untreated women with persistent type-specific HPV DNA detected (270 infections) in at least three of the last smears for a average period of 3.2 years. Using the coefficient of determination (R²) infections could be subdivided in a latency group (n = 143; R² < 0.85) and a regressing group (n = 127; R² ≥ 0.85). In (≥3) serial viral load measurements, serial transient infections with latency is characterized by a nonlinear limited difference in decrease or increase of type-specific viral load (R² < 0.85 and slopes between 2 measurements 0.0010 and −0.0010 HPV copies/cell per day) over a longer period of time (1553 days), whereas regression of a clonal cell population is characterized by a linear (R² ≥ 0.85) decrease (−0.0033 HPV copies/cell per day) over a shorter period of time (708 days; P < 0.001). Using serial HPV type-specific viral load measurements we could for the first time identify regressing CIN2 and CIN3 lesions. Evolution of the viral load is an objective measurable indicator of the natural history of HPV infections and could be used for future triage in HPV-based cervical screening programs." @default.
• W1937133798 created "2016-06-24" @default.
• W1937133798 creator A5022514237 @default.
• W1937133798 creator A5028248841 @default.
• W1937133798 creator A5039645858 @default.
• W1937133798 creator A5071665734 @default.
• W1937133798 creator A5076222347 @default.
• W1937133798 creator A5082064953 @default.
• W1937133798 date "2015-05-20" @default.
• W1937133798 modified "2023-09-24" @default.
• W1937133798 title "Serial type-specific human papillomavirus (HPV) load measurement allows differentiation between regressing cervical lesions and serial virion productive transient infections" @default.
• W1937133798 cites W1562069246 @default.
• W1937133798 cites W1964162820 @default.
• W1937133798 cites W1968965657 @default.
• W1937133798 cites W1973675115 @default.
• W1937133798 cites W1987350137 @default.
• W1937133798 cites W2001572049 @default.
• W1937133798 cites W2018760046 @default.
• W1937133798 cites W2027172110 @default.
• W1937133798 cites W2051475540 @default.
• W1937133798 cites W2067442281 @default.
• W1937133798 cites W2074766470 @default.
• W1937133798 cites W2075692523 @default.
• W1937133798 cites W2084494076 @default.
• W1937133798 cites W2103648930 @default.
• W1937133798 cites W2114813165 @default.
• W1937133798 cites W2124403004 @default.
• W1937133798 cites W2135045906 @default.
• W1937133798 cites W2136268327 @default.
• W1937133798 cites W2138746759 @default.
• W1937133798 cites W2144175542 @default.
• W1937133798 cites W2164328573 @default.
• W1937133798 cites W2168181991 @default.
• W1937133798 cites W2169767104 @default.
• W1937133798 cites W2412326455 @default.
• W1937133798 doi "https://doi.org/10.1002/cam4.473" @default.
• W1937133798 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4559041" @default.
• W1937133798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25991420" @default.
• W1937133798 hasPublicationYear "2015" @default.
• W1937133798 type Work @default.
• W1937133798 sameAs 1937133798 @default.
• W1937133798 citedByCount "50" @default.
• W1937133798 countsByYear W19371337982015 @default.
• W1937133798 countsByYear W19371337982016 @default.
• W1937133798 countsByYear W19371337982017 @default.
• W1937133798 countsByYear W19371337982018 @default.
• W1937133798 countsByYear W19371337982019 @default.
• W1937133798 countsByYear W19371337982020 @default.
• W1937133798 countsByYear W19371337982021 @default.
• W1937133798 countsByYear W19371337982022 @default.
• W1937133798 countsByYear W19371337982023 @default.
• W1937133798 crossrefType "journal-article" @default.
• W1937133798 hasAuthorship W1937133798A5022514237 @default.
• W1937133798 hasAuthorship W1937133798A5028248841 @default.
• W1937133798 hasAuthorship W1937133798A5039645858 @default.
• W1937133798 hasAuthorship W1937133798A5071665734 @default.
• W1937133798 hasAuthorship W1937133798A5076222347 @default.
• W1937133798 hasAuthorship W1937133798A5082064953 @default.
• W1937133798 hasBestOaLocation W19371337981 @default.
• W1937133798 hasConcept C121608353 @default.
• W1937133798 hasConcept C126322002 @default.
• W1937133798 hasConcept C142462285 @default.
• W1937133798 hasConcept C143590678 @default.
• W1937133798 hasConcept C159047783 @default.
• W1937133798 hasConcept C163276114 @default.
• W1937133798 hasConcept C203014093 @default.
• W1937133798 hasConcept C2522874641 @default.
• W1937133798 hasConcept C2777343196 @default.
• W1937133798 hasConcept C2778220009 @default.
• W1937133798 hasConcept C2778580637 @default.
• W1937133798 hasConcept C2908647359 @default.
• W1937133798 hasConcept C71924100 @default.
• W1937133798 hasConcept C86803240 @default.
• W1937133798 hasConcept C99454951 @default.
• W1937133798 hasConceptScore W1937133798C121608353 @default.
• W1937133798 hasConceptScore W1937133798C126322002 @default.
• W1937133798 hasConceptScore W1937133798C142462285 @default.
• W1937133798 hasConceptScore W1937133798C143590678 @default.
• W1937133798 hasConceptScore W1937133798C159047783 @default.
• W1937133798 hasConceptScore W1937133798C163276114 @default.
• W1937133798 hasConceptScore W1937133798C203014093 @default.
• W1937133798 hasConceptScore W1937133798C2522874641 @default.
• W1937133798 hasConceptScore W1937133798C2777343196 @default.
• W1937133798 hasConceptScore W1937133798C2778220009 @default.
• W1937133798 hasConceptScore W1937133798C2778580637 @default.
• W1937133798 hasConceptScore W1937133798C2908647359 @default.
• W1937133798 hasConceptScore W1937133798C71924100 @default.
• W1937133798 hasConceptScore W1937133798C86803240 @default.
• W1937133798 hasConceptScore W1937133798C99454951 @default.
• W1937133798 hasIssue "8" @default.
• W1937133798 hasLocation W19371337981 @default.
• W1937133798 hasLocation W19371337982 @default.
• W1937133798 hasLocation W19371337983 @default.
• W1937133798 hasLocation W19371337984 @default.
• W1937133798 hasLocation W19371337985 @default.
• W1937133798 hasOpenAccess W1937133798 @default.
• W1937133798 hasPrimaryLocation W19371337981 @default.
• W1937133798 hasRelatedWork W147290333 @default.

• next