FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1937242593> ?p ?o ?g. }

• W1937242593 endingPage "11" @default.
• W1937242593 startingPage "11" @default.
• W1937242593 abstract "Inflammatory breast cancer (IBC) is the most lethal form of locally invasive breast cancer known. However, very little information is available on the cellular mechanisms responsible for manifestation of the IBC phenotype. To understand the unique phenotype of IBC, we compared the motile and adhesive interactions of an IBC cell line, SUM 149, to the non-IBC cell line SUM 102. Our results demonstrate that both IBC and non-IBC cell lines exhibit similar adhesive properties to basal lamina, but SUM 149 showed a marked increase in adhesion to collagen I. In vitro haptotaxis assays demonstrate that SUM 149 was less invasive, while wound healing assays show a less in vitro migratory phenotype for SUM 149 cells relative to SUM 102 cells. We also demonstrate a role for Rho and E-cadherin in the unique invasive phenotype of IBC. Immunoblotting reveals higher E-cadherin and RhoA expression in the IBC cell line but similar RhoC expression. Rhodamine phalloidin staining demonstrates increased formation of actin stress fibers and larger focal adhesions in SUM 149 relative to the SUM 102 cell line. The observed unique actin and cellular architecture as well as the invasive and adhesive responses to the extracellular matrix of SUM 149 IBC cells suggest that the preference of IBC cells for connective tissue, possibly a mediator important for the vasculogenic mimicry via tubulogenesis seen in IBC pathological specimens. Overexpression of E-cadherin and RhoA may contribute to passive dissemination of IBC by promoting cell-cell adhesion and actin cytoskeletal structures that maintain tissue integrity. Therefore, we believe that these findings indicate a passive metastatic mechanism by which IBC cells invade the circulatory system as tumor emboli rather than by active migratory mechanisms." @default.
• W1937242593 created "2016-06-24" @default.
• W1937242593 creator A5026855277 @default.
• W1937242593 creator A5027987017 @default.
• W1937242593 creator A5047703495 @default.
• W1937242593 date "2005-01-01" @default.
• W1937242593 modified "2023-09-24" @default.
• W1937242593 cites W1483520515 @default.
• W1937242593 cites W1488849446 @default.
• W1937242593 cites W1596245619 @default.
• W1937242593 cites W1905957625 @default.
• W1937242593 cites W1910650341 @default.
• W1937242593 cites W1935704531 @default.
• W1937242593 cites W1949238489 @default.
• W1937242593 cites W1968826282 @default.
• W1937242593 cites W1971964944 @default.
• W1937242593 cites W1971993769 @default.
• W1937242593 cites W1978988073 @default.
• W1937242593 cites W1981228379 @default.
• W1937242593 cites W1985723830 @default.
• W1937242593 cites W1990580084 @default.
• W1937242593 cites W1993641273 @default.
• W1937242593 cites W1996733845 @default.
• W1937242593 cites W2016312253 @default.
• W1937242593 cites W2025077054 @default.
• W1937242593 cites W2029120648 @default.
• W1937242593 cites W2029413197 @default.
• W1937242593 cites W2032096510 @default.
• W1937242593 cites W2034566357 @default.
• W1937242593 cites W2048906578 @default.
• W1937242593 cites W2066211195 @default.
• W1937242593 cites W2067907901 @default.
• W1937242593 cites W2082344537 @default.
• W1937242593 cites W2083267106 @default.
• W1937242593 cites W2092550529 @default.
• W1937242593 cites W2107029948 @default.
• W1937242593 cites W2120513402 @default.
• W1937242593 cites W2121714207 @default.
• W1937242593 cites W2127138193 @default.
• W1937242593 cites W2127332058 @default.
• W1937242593 cites W2128797396 @default.
• W1937242593 cites W2137604636 @default.
• W1937242593 cites W2150415238 @default.
• W1937242593 cites W2152396103 @default.
• W1937242593 cites W2156537523 @default.
• W1937242593 cites W2188735123 @default.
• W1937242593 cites W2293143569 @default.
• W1937242593 cites W2375169070 @default.
• W1937242593 doi "https://doi.org/10.1186/1475-2867-5-11" @default.
• W1937242593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1090601" @default.
• W1937242593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15857504" @default.
• W1937242593 hasPublicationYear "2005" @default.
• W1937242593 type Work @default.
• W1937242593 sameAs 1937242593 @default.
• W1937242593 citedByCount "52" @default.
• W1937242593 countsByYear W19372425932012 @default.
• W1937242593 countsByYear W19372425932013 @default.
• W1937242593 countsByYear W19372425932014 @default.
• W1937242593 countsByYear W19372425932015 @default.
• W1937242593 countsByYear W19372425932016 @default.
• W1937242593 countsByYear W19372425932017 @default.
• W1937242593 countsByYear W19372425932018 @default.
• W1937242593 countsByYear W19372425932020 @default.
• W1937242593 countsByYear W19372425932021 @default.
• W1937242593 countsByYear W19372425932022 @default.
• W1937242593 countsByYear W19372425932023 @default.
• W1937242593 crossrefType "journal-article" @default.
• W1937242593 hasAuthorship W1937242593A5026855277 @default.
• W1937242593 hasAuthorship W1937242593A5027987017 @default.
• W1937242593 hasAuthorship W1937242593A5047703495 @default.
• W1937242593 hasBestOaLocation W19372425931 @default.
• W1937242593 hasConcept C142669718 @default.
• W1937242593 hasConcept C1491633281 @default.
• W1937242593 hasConcept C149402561 @default.
• W1937242593 hasConcept C151166631 @default.
• W1937242593 hasConcept C189165786 @default.
• W1937242593 hasConcept C2777093181 @default.
• W1937242593 hasConcept C54355233 @default.
• W1937242593 hasConcept C62478195 @default.
• W1937242593 hasConcept C81885089 @default.
• W1937242593 hasConcept C85789140 @default.
• W1937242593 hasConcept C86803240 @default.
• W1937242593 hasConcept C95444343 @default.
• W1937242593 hasConceptScore W1937242593C142669718 @default.
• W1937242593 hasConceptScore W1937242593C1491633281 @default.
• W1937242593 hasConceptScore W1937242593C149402561 @default.
• W1937242593 hasConceptScore W1937242593C151166631 @default.
• W1937242593 hasConceptScore W1937242593C189165786 @default.
• W1937242593 hasConceptScore W1937242593C2777093181 @default.
• W1937242593 hasConceptScore W1937242593C54355233 @default.
• W1937242593 hasConceptScore W1937242593C62478195 @default.
• W1937242593 hasConceptScore W1937242593C81885089 @default.
• W1937242593 hasConceptScore W1937242593C85789140 @default.
• W1937242593 hasConceptScore W1937242593C86803240 @default.
• W1937242593 hasConceptScore W1937242593C95444343 @default.
• W1937242593 hasIssue "1" @default.
• W1937242593 hasLocation W19372425931 @default.
• W1937242593 hasLocation W19372425932 @default.

• next