FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1937248336> ?p ?o ?g. }

• W1937248336 endingPage "286" @default.
• W1937248336 startingPage "272" @default.
• W1937248336 abstract "Thermenos HW, Makris N, Whitfield-Gabrieli S, Brown AB, Giuliano AJ, Lee EH, Faraone SV, Tsuang MT, Seidman LJ. A functional MRI study of working memory in adolescents and young adults at genetic risk for bipolar disorder: preliminary findings.Bipolar Disord 2011: 13: 272–286. © 2011 The Authors.Journal compilation © 2011 John Wiley & Sons A/S. Objectives: In this report, we seek to (i) identify a potential neuroimaging endophenotype for bipolar disorder (BD) in emotion regulatory and autonomic circuitry in young first-degree relatives of persons with BD; and (ii) replicate our previous work identifying the functional neuroanatomy of working memory (WM) in an older sample of relatives of persons with BD. Methods: Ten adolescent and young adult (age 13–24) unmedicated, non-ill, first-degree relatives of persons with BD (RELS) and 10 demographically comparable healthy controls performed a 2-back WM task and a 0-back control task during functional magnetic resonance imaging (fMRI). fMRI data were collected on a 1.5 Tesla scanner and analyzed using SPM-2. Mood was assessed on the day of scanning. Results: The groups did not differ on any demographic, neuropsychological, or in-scanner task performance variables. In contrast to controls, RELS showed (i) weak task-dependent modulation activity in the cerebellar vermis (CV), insula, and amygdala/parahippocampal region, and (ii) exaggerated modulation of activity in the frontopolar cortex and brainstem, even after controlling for potential confounders. Many of the group differences were driven by differences in activity in the low-level (0-back) baseline task. Conclusions: Young, unmedicated RELS exhibited altered task-dependent modulation of frontopolar, CV, and insula activity during WM, especially during the low-level (0-back) baseline task. Results are largely consistent with our initial study of older adult RELS, suggesting these alterations may represent biomarkers of genetic risk for BD." @default.
• W1937248336 created "2016-06-24" @default.
• W1937248336 creator A5005205646 @default.
• W1937248336 creator A5005253469 @default.
• W1937248336 creator A5012499268 @default.
• W1937248336 creator A5018822834 @default.
• W1937248336 creator A5044176155 @default.
• W1937248336 creator A5052145058 @default.
• W1937248336 creator A5069805388 @default.
• W1937248336 creator A5070432869 @default.
• W1937248336 creator A5087475934 @default.
• W1937248336 date "2011-05-01" @default.
• W1937248336 modified "2023-10-18" @default.
• W1937248336 title "A functional MRI study of working memory in adolescents and young adults at genetic risk for bipolar disorder: preliminary findings" @default.
• W1937248336 cites W1525298240 @default.
• W1937248336 cites W1549658809 @default.
• W1937248336 cites W1582811168 @default.
• W1937248336 cites W1634720708 @default.
• W1937248336 cites W1805858390 @default.
• W1937248336 cites W1963525383 @default.
• W1937248336 cites W1966111889 @default.
• W1937248336 cites W1971573284 @default.
• W1937248336 cites W1972854636 @default.
• W1937248336 cites W1976336543 @default.
• W1937248336 cites W1979487363 @default.
• W1937248336 cites W1985689469 @default.
• W1937248336 cites W2000697043 @default.
• W1937248336 cites W2002337595 @default.
• W1937248336 cites W2004056298 @default.
• W1937248336 cites W2005244676 @default.
• W1937248336 cites W2007269923 @default.
• W1937248336 cites W2009912729 @default.
• W1937248336 cites W2012336724 @default.
• W1937248336 cites W2017222115 @default.
• W1937248336 cites W2019485942 @default.
• W1937248336 cites W2021466698 @default.
• W1937248336 cites W2023073162 @default.
• W1937248336 cites W2023202278 @default.
• W1937248336 cites W2024337244 @default.
• W1937248336 cites W2025577666 @default.
• W1937248336 cites W2033007921 @default.
• W1937248336 cites W2033681957 @default.
• W1937248336 cites W2034403347 @default.
• W1937248336 cites W2040075391 @default.
• W1937248336 cites W2043013393 @default.
• W1937248336 cites W2045088017 @default.
• W1937248336 cites W2050419482 @default.
• W1937248336 cites W2050753235 @default.
• W1937248336 cites W2051612014 @default.
• W1937248336 cites W2055210002 @default.
• W1937248336 cites W2055618902 @default.
• W1937248336 cites W2065462676 @default.
• W1937248336 cites W2070406432 @default.
• W1937248336 cites W2070431099 @default.
• W1937248336 cites W2070752314 @default.
• W1937248336 cites W2072061544 @default.
• W1937248336 cites W2073332142 @default.
• W1937248336 cites W2077455126 @default.
• W1937248336 cites W2078447042 @default.
• W1937248336 cites W2081622818 @default.
• W1937248336 cites W2083594505 @default.
• W1937248336 cites W2083733140 @default.
• W1937248336 cites W2084018700 @default.
• W1937248336 cites W2084737564 @default.
• W1937248336 cites W2085647841 @default.
• W1937248336 cites W2087203905 @default.
• W1937248336 cites W2087645794 @default.
• W1937248336 cites W2095068146 @default.
• W1937248336 cites W2095088925 @default.
• W1937248336 cites W2097139733 @default.
• W1937248336 cites W2097812147 @default.
• W1937248336 cites W2098636687 @default.
• W1937248336 cites W2100329263 @default.
• W1937248336 cites W2104170262 @default.
• W1937248336 cites W2105158739 @default.
• W1937248336 cites W2107751666 @default.
• W1937248336 cites W2111464173 @default.
• W1937248336 cites W2115789347 @default.
• W1937248336 cites W2120160609 @default.
• W1937248336 cites W2125972603 @default.
• W1937248336 cites W2130221071 @default.
• W1937248336 cites W2131165483 @default.
• W1937248336 cites W2131864009 @default.
• W1937248336 cites W2136474114 @default.
• W1937248336 cites W2137329623 @default.
• W1937248336 cites W2138526638 @default.
• W1937248336 cites W2140193616 @default.
• W1937248336 cites W2140433911 @default.
• W1937248336 cites W2140661724 @default.
• W1937248336 cites W2141300297 @default.
• W1937248336 cites W2145069535 @default.
• W1937248336 cites W2150866487 @default.
• W1937248336 cites W2153675071 @default.
• W1937248336 cites W2155619915 @default.
• W1937248336 cites W2166192486 @default.
• W1937248336 cites W2169230464 @default.
• W1937248336 cites W2244803087 @default.
• W1937248336 cites W4230969033 @default.

• next