FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1937264217> ?p ?o ?g. }

• W1937264217 endingPage "2179" @default.
• W1937264217 startingPage "2169" @default.
• W1937264217 abstract "Outer membrane protein TolC serves as an exit duct for exporting substances out of cell. The occluded periplasmic entrance of TolC is required to open for substrate transport, although the opening mechanism remains elusive. In this study, systematic molecular dynamics (MD) simulations for wild type TolC and six mutants were performed to explore the conformational dynamics of TolC. The periplasmic gate was shown to sample multiple conformational states with various degrees of gating opening. The gate opening was facilitated by all mutations except Y362F, which adopts an even more closed state than wild type TolC. The interprotomer salt-bridge R367–D153 is turned out to be crucial for periplasmic gate opening. The mutations that disrupt the interactions at the periplasmic tip may affect the stability of the trimeric assembly of TolC. Structural asymmetry of the periplasmic gate was observed to be opening size dependent. Asymmetric conformations are found in moderately opening states, while the most and the least opening states are often more symmetric. Finally, it is shown that lowering pH can remarkably stabilize the closed state of the periplasmic gate. Proteins 2014; 82:2169–2179. © 2014 Wiley Periodicals, Inc." @default.
• W1937264217 created "2016-06-24" @default.
• W1937264217 creator A5002073070 @default.
• W1937264217 creator A5012022141 @default.
• W1937264217 creator A5039234406 @default.
• W1937264217 date "2014-06-09" @default.
• W1937264217 modified "2023-09-27" @default.
• W1937264217 title "Multiple conformational states and gate opening of outer membrane protein TolC revealed by molecular dynamics simulations" @default.
• W1937264217 cites W1542579814 @default.
• W1937264217 cites W1892148740 @default.
• W1937264217 cites W1910484851 @default.
• W1937264217 cites W1944808330 @default.
• W1937264217 cites W1965254579 @default.
• W1937264217 cites W1974030600 @default.
• W1937264217 cites W1976499671 @default.
• W1937264217 cites W1976993208 @default.
• W1937264217 cites W1996452607 @default.
• W1937264217 cites W2006567164 @default.
• W1937264217 cites W2019432740 @default.
• W1937264217 cites W2021927242 @default.
• W1937264217 cites W2023472866 @default.
• W1937264217 cites W2024225780 @default.
• W1937264217 cites W2029667189 @default.
• W1937264217 cites W2032226429 @default.
• W1937264217 cites W2034979953 @default.
• W1937264217 cites W2035266068 @default.
• W1937264217 cites W2038758364 @default.
• W1937264217 cites W2041308144 @default.
• W1937264217 cites W2053628548 @default.
• W1937264217 cites W2059933957 @default.
• W1937264217 cites W2061558163 @default.
• W1937264217 cites W2061856372 @default.
• W1937264217 cites W2067174909 @default.
• W1937264217 cites W2105573149 @default.
• W1937264217 cites W2122127748 @default.
• W1937264217 cites W2123032774 @default.
• W1937264217 cites W2150981663 @default.
• W1937264217 cites W2160544821 @default.
• W1937264217 cites W2167556437 @default.
• W1937264217 cites W2168240189 @default.
• W1937264217 cites W2314650431 @default.
• W1937264217 cites W2327586557 @default.
• W1937264217 cites W3017082821 @default.
• W1937264217 doi "https://doi.org/10.1002/prot.24573" @default.
• W1937264217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24706332" @default.
• W1937264217 hasPublicationYear "2014" @default.
• W1937264217 type Work @default.
• W1937264217 sameAs 1937264217 @default.
• W1937264217 citedByCount "9" @default.
• W1937264217 countsByYear W19372642172015 @default.
• W1937264217 countsByYear W19372642172017 @default.
• W1937264217 countsByYear W19372642172019 @default.
• W1937264217 countsByYear W19372642172021 @default.
• W1937264217 countsByYear W19372642172022 @default.
• W1937264217 countsByYear W19372642172023 @default.
• W1937264217 crossrefType "journal-article" @default.
• W1937264217 hasAuthorship W1937264217A5002073070 @default.
• W1937264217 hasAuthorship W1937264217A5012022141 @default.
• W1937264217 hasAuthorship W1937264217A5039234406 @default.
• W1937264217 hasConcept C104317684 @default.
• W1937264217 hasConcept C12554922 @default.
• W1937264217 hasConcept C146587185 @default.
• W1937264217 hasConcept C147597530 @default.
• W1937264217 hasConcept C185592680 @default.
• W1937264217 hasConcept C201663137 @default.
• W1937264217 hasConcept C47701112 @default.
• W1937264217 hasConcept C547475151 @default.
• W1937264217 hasConcept C55493867 @default.
• W1937264217 hasConcept C59593255 @default.
• W1937264217 hasConcept C8010536 @default.
• W1937264217 hasConcept C86803240 @default.
• W1937264217 hasConceptScore W1937264217C104317684 @default.
• W1937264217 hasConceptScore W1937264217C12554922 @default.
• W1937264217 hasConceptScore W1937264217C146587185 @default.
• W1937264217 hasConceptScore W1937264217C147597530 @default.
• W1937264217 hasConceptScore W1937264217C185592680 @default.
• W1937264217 hasConceptScore W1937264217C201663137 @default.
• W1937264217 hasConceptScore W1937264217C47701112 @default.
• W1937264217 hasConceptScore W1937264217C547475151 @default.
• W1937264217 hasConceptScore W1937264217C55493867 @default.
• W1937264217 hasConceptScore W1937264217C59593255 @default.
• W1937264217 hasConceptScore W1937264217C8010536 @default.
• W1937264217 hasConceptScore W1937264217C86803240 @default.
• W1937264217 hasFunder F4320336024 @default.
• W1937264217 hasIssue "9" @default.
• W1937264217 hasLocation W19372642171 @default.
• W1937264217 hasLocation W19372642172 @default.
• W1937264217 hasOpenAccess W1937264217 @default.
• W1937264217 hasPrimaryLocation W19372642171 @default.
• W1937264217 hasRelatedWork W1937264217 @default.
• W1937264217 hasRelatedWork W2053628548 @default.
• W1937264217 hasRelatedWork W2101191100 @default.
• W1937264217 hasRelatedWork W2108623931 @default.
• W1937264217 hasRelatedWork W2158331661 @default.
• W1937264217 hasRelatedWork W2170477725 @default.
• W1937264217 hasRelatedWork W2277949932 @default.
• W1937264217 hasRelatedWork W2537282895 @default.
• W1937264217 hasRelatedWork W2914605563 @default.

• next