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- W1937308268 abstract "Abstract There is an increasing awareness that some genes do not behave in a strictly Mendelian fashion. In plants, flies, and mice, some alleles have been identified where the activity state varies among cells of the same cell type (termed variegation) and among genetically identical individuals (variable expressivity). We now know that this is the result of the stochastic establishment of differential epigenetic states at the locus. These states are set up during early development and are stably inherited for the life of the organism. While, in general, the states are cleared between generations, this is not always the case. Some alleles, now referred to as metastable epialleles, are not completely cleared from one generation to the next, resulting in a phenomenon termed transgenerational epigenetic inheritance . One of the interesting questions that arises from these findings is whether this mechanism has been involved in the evolution of morphological traits." @default.
- W1937308268 created "2016-06-24" @default.
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- W1937308268 date "2005-07-15" @default.
- W1937308268 modified "2023-10-18" @default.
- W1937308268 title "Variable expressivity and epigenetics" @default.
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- W1937308268 doi "https://doi.org/10.1002/047001153x.g103324" @default.
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