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• W1937331920 abstract "PIEPPONEN, T. P., T. KIVASTIK, J. KATAJAMAKI, A. ZHARKOVSKY AND L. AHTEE. Involvement of opioid pi-receptors in morphine-induced place prefer­ ence in rats. PHARMACOL BIOCHEM BEHAV. The main purpose of this study was to evaluate the role of |il-opioid receptors in morphine reward. Therefore, we studied the ability of (j 1 selective antagonist, naloxonazine (15 mg/kg, IP), to an­ tagonize the conditioned place preference (CPP) induced by morphine (3 mg/kg, SC). In addition, effects of naloxonazine on morphine-induced catalepsy (15 mg/kg), analgesia (3 mg/kg) and hyperthermia (3 mg/kg) were studied. For comparison, the effects of a non-selective opioid receptor antagonist, naltrexone (2.5 mg/kg, SC), and a selective 8-opioid receptor antagonist, naltrindole (2 mg/kg, IP), on CPP induced by morphine were investigated. Morphine-induced CPP was clearly antagonized by pretreatment with naloxonazine and naltrexone (12 h and 20 min prior to morphine, respectively) but not by naltrindole (15 min before mor­ phine). Naloxonazine also antagonized morphine-induced catalepsy and analgesia but not morphine-induced hyperthermia. Naltrindole did not modify morphine-in- duced catalepsy. These results suggest an active role for pi-opioid receptors in morphine reward, whereas morphine-induced hyperthermia does not appear to be mediated by jn 1 -opioid receptors. Furthermore, 5-opioid receptors seem to be with­ out significance in morphine-induced reward. Naltrexone, Naloxonazine, Naltrindole, Conditioned place preference, Catalepsy, Analgesia, Hyperthermia, Opioid receptors" @default.
• W1937331920 created "2016-06-24" @default.
• W1937331920 creator A5063475782 @default.
• W1937331920 date "1996-01-01" @default.
• W1937331920 modified "2023-09-23" @default.
• W1937331920 title "MECHANISMS OF DRUG ADDICTION: FOCUS ON POSITIVE REINFORCING PROPERTIES OF MORPHINE" @default.
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