Matches in SemOpenAlex for { <https://semopenalex.org/work/W1937351619> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1937351619 endingPage "14" @default.
- W1937351619 startingPage "8" @default.
- W1937351619 abstract "A simple gradient reversed phase high performance liquid chromatographic method was developed for the determination of ambroxol hydrochloride in presence of antimicrobial preservatives in oral liquid formulation. The chromatographic separation was achieved by an Inertsil C8 (250 X 4.6 mm, 5? particle size) column using gradient technique. The eluents were detected at 245 nm with photodiode array detector. The optimized mobile phase consisted of 0.1% trifluoroacetic acid as a mobile phase A and a mixture of mobile phase A and acetonitrile in the ratio of 76:24 % v/v as mobile phase B. Ambroxol hydrochloride and microbial preservatives were eluted at a flow rate of 1.0 ml/min. The method validated according to the International Conference of Harmonization (ICH) guidelines. The calibration curves were linear over the (r2 > 0.99) concentrations range from 300 to 900 ppm for ambroxol hydrochloride, 10 to 30 ppm for propyl paraben and 100 to 300 ppm for methyl paraben. The limit of detection was found to be 0.024 ppm for ambroxol hydrochloride, 0.018 ppm for propyl paraben and 0.009 ppm for methyl paraben. The percentage recoveries were found to be in the range from 99.55 to 101.1% for ambroxol hydrochloride, 100.31 to 101.46% for propyl paraben and 98.18 to 101.61% for methyl paraben. Stability indicating capability was established by forced degradation experiments. No chromatographic interference from the degradation products was found. The proposed method was highly sensitive, precision and accurate and hence successfully applied for the quantification of ambroxol active pharmaceutical ingredients (API) and preservatives content in the commercially available oral liquid formulation.Bangladesh Pharmaceutical Journal 18(1): 8-14, 2015" @default.
- W1937351619 created "2016-06-24" @default.
- W1937351619 creator A5003113623 @default.
- W1937351619 creator A5003758788 @default.
- W1937351619 creator A5033143913 @default.
- W1937351619 creator A5082968627 @default.
- W1937351619 date "2015-06-01" @default.
- W1937351619 modified "2023-09-27" @default.
- W1937351619 title "High performance liquid chromatographic method for the determination of ambroxol hydrochloride in presence of antimicrobial preservatives in oral liquid formulation" @default.
- W1937351619 cites W1968820489 @default.
- W1937351619 cites W1979621862 @default.
- W1937351619 cites W1981245891 @default.
- W1937351619 cites W1988931177 @default.
- W1937351619 cites W1989587731 @default.
- W1937351619 cites W1992678996 @default.
- W1937351619 cites W1998921487 @default.
- W1937351619 cites W2003056190 @default.
- W1937351619 cites W2008586669 @default.
- W1937351619 cites W2008910471 @default.
- W1937351619 cites W2025991102 @default.
- W1937351619 cites W2034019771 @default.
- W1937351619 cites W2046670434 @default.
- W1937351619 cites W2068938510 @default.
- W1937351619 cites W2088322687 @default.
- W1937351619 cites W2091269995 @default.
- W1937351619 cites W2267736904 @default.
- W1937351619 cites W2461968100 @default.
- W1937351619 cites W2486528993 @default.
- W1937351619 cites W2602921533 @default.
- W1937351619 doi "https://doi.org/10.3329/bpj.v18i1.23505" @default.
- W1937351619 hasPublicationYear "2015" @default.
- W1937351619 type Work @default.
- W1937351619 sameAs 1937351619 @default.
- W1937351619 citedByCount "1" @default.
- W1937351619 countsByYear W19373516192018 @default.
- W1937351619 crossrefType "journal-article" @default.
- W1937351619 hasAuthorship W1937351619A5003113623 @default.
- W1937351619 hasAuthorship W1937351619A5003758788 @default.
- W1937351619 hasAuthorship W1937351619A5033143913 @default.
- W1937351619 hasAuthorship W1937351619A5082968627 @default.
- W1937351619 hasBestOaLocation W19373516191 @default.
- W1937351619 hasConcept C119128265 @default.
- W1937351619 hasConcept C178790620 @default.
- W1937351619 hasConcept C185592680 @default.
- W1937351619 hasConcept C2776330663 @default.
- W1937351619 hasConcept C2779370918 @default.
- W1937351619 hasConcept C42219234 @default.
- W1937351619 hasConcept C43617362 @default.
- W1937351619 hasConcept C67031304 @default.
- W1937351619 hasConcept C71924100 @default.
- W1937351619 hasConceptScore W1937351619C119128265 @default.
- W1937351619 hasConceptScore W1937351619C178790620 @default.
- W1937351619 hasConceptScore W1937351619C185592680 @default.
- W1937351619 hasConceptScore W1937351619C2776330663 @default.
- W1937351619 hasConceptScore W1937351619C2779370918 @default.
- W1937351619 hasConceptScore W1937351619C42219234 @default.
- W1937351619 hasConceptScore W1937351619C43617362 @default.
- W1937351619 hasConceptScore W1937351619C67031304 @default.
- W1937351619 hasConceptScore W1937351619C71924100 @default.
- W1937351619 hasIssue "1" @default.
- W1937351619 hasLocation W19373516191 @default.
- W1937351619 hasOpenAccess W1937351619 @default.
- W1937351619 hasPrimaryLocation W19373516191 @default.
- W1937351619 hasRelatedWork W1937351619 @default.
- W1937351619 hasRelatedWork W2025991102 @default.
- W1937351619 hasRelatedWork W2038968156 @default.
- W1937351619 hasRelatedWork W2068992395 @default.
- W1937351619 hasRelatedWork W2284879249 @default.
- W1937351619 hasRelatedWork W2384472039 @default.
- W1937351619 hasRelatedWork W2394112366 @default.
- W1937351619 hasRelatedWork W2520877371 @default.
- W1937351619 hasRelatedWork W4317620679 @default.
- W1937351619 hasRelatedWork W2334177263 @default.
- W1937351619 hasVolume "18" @default.
- W1937351619 isParatext "false" @default.
- W1937351619 isRetracted "false" @default.
- W1937351619 magId "1937351619" @default.
- W1937351619 workType "article" @default.