FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1937377332> ?p ?o ?g. }

• W1937377332 abstract "Runt-related transcription factor 3 (RUNX3) is a known regulator in the transforming growth factor (TGF)-β signaling pathway, which promoter methylation playing a crucial role in diverse neoplasias. However, the relationship between RUNX3 promoter methylation and non-small cell lung cancer (NSCLC) remains to be clarified.We searched Pubmed, Embase, Cochrane Central, and Chinese Biological Medicine database, for articles published in English or Chinese until March 7, 2014. Our main analyses were focused on the association between RUNX3 promoter methylation and risk of NSCLC by meta-analysis methods. If heterogeneity was observed, we used random effects model to calculate the overall odds ratios, otherwise fixed effects model was used. Subgroup analyses and meta-regression analyses were employed to detect the sources of the heterogeneity. Sensitivity analysis was performed to evaluate the stability of our studies. A funnel plot and Egger's test were conducted to investigate any potential publication bias.A total of 1,368 samples from 13 literatures were involved in this meta-analysis. The pooled odds ratio (OR) of RUNX3 methylation in NSCLC specimens compared to non-cancer controls was 6.70 [95% confidence interval (CI): 4.64-9.67]. In the analysis of specimen-types subgroup, the summary OR was 5.79 (95% CI: 3.97-8.46) for tissue specimen subgroup, and that was 45.64 (95% CI: 5.89-353.72) for serum specimen subgroup. The ORs for the age ≤60 years, 60-65 years and >65 years subgroup were 5.19 (95% CI: 3.27-8.24), 9.45 (95% CI: 2.45-36.45) and 13.23 (95% CI: 5.59-31.28) respectively. The result of meta-regression indicated that age was fundamental source of heterogeneity (coefficient =0.61, P=0.046, adjusted R(2) =100%). No publication bias was detected. In cancer specimens, the RUNX3 methylation was associated with histological type of the NSCLC, but no significant differences were found for RUNX3 methylation in relation to gender, smoking history, tumor TNM stage or tumor differentiation level.This meta-analysis of pooled data provides additional evidence to support a strong association between methylation of the RUNX3 promoter and NSCLC. RUNX3 methylation was increasing with age." @default.
• W1937377332 created "2016-06-24" @default.
• W1937377332 creator A5020473726 @default.
• W1937377332 creator A5033111915 @default.
• W1937377332 creator A5033166140 @default.
• W1937377332 creator A5044400067 @default.
• W1937377332 creator A5061529098 @default.
• W1937377332 date "2014-06-01" @default.
• W1937377332 modified "2023-09-24" @default.
• W1937377332 title "Association between RUNX3 promoter methylation and non-small cell lung cancer: a meta-analysis." @default.
• W1937377332 cites W1504303645 @default.
• W1937377332 cites W1537175468 @default.
• W1937377332 cites W1658127082 @default.
• W1937377332 cites W1967849315 @default.
• W1937377332 cites W1970273243 @default.
• W1937377332 cites W1970885825 @default.
• W1937377332 cites W1975003033 @default.
• W1937377332 cites W1981339217 @default.
• W1937377332 cites W1981564930 @default.
• W1937377332 cites W1989078517 @default.
• W1937377332 cites W1989585142 @default.
• W1937377332 cites W1990055657 @default.
• W1937377332 cites W2007715266 @default.
• W1937377332 cites W2012911193 @default.
• W1937377332 cites W2014140361 @default.
• W1937377332 cites W2020871542 @default.
• W1937377332 cites W2021527895 @default.
• W1937377332 cites W2030110104 @default.
• W1937377332 cites W2045225294 @default.
• W1937377332 cites W2058046534 @default.
• W1937377332 cites W2063423348 @default.
• W1937377332 cites W2065949767 @default.
• W1937377332 cites W2067727760 @default.
• W1937377332 cites W2071550970 @default.
• W1937377332 cites W2073200351 @default.
• W1937377332 cites W2079419271 @default.
• W1937377332 cites W2081465456 @default.
• W1937377332 cites W2090935417 @default.
• W1937377332 cites W2093682184 @default.
• W1937377332 cites W2096865440 @default.
• W1937377332 cites W2101995865 @default.
• W1937377332 cites W2110845635 @default.
• W1937377332 cites W2119542428 @default.
• W1937377332 cites W2125898440 @default.
• W1937377332 cites W2134694717 @default.
• W1937377332 cites W2138658765 @default.
• W1937377332 cites W2139498844 @default.
• W1937377332 cites W2151089679 @default.
• W1937377332 cites W2156681756 @default.
• W1937377332 cites W2169256892 @default.
• W1937377332 cites W2169385429 @default.
• W1937377332 cites W2376258942 @default.
• W1937377332 cites W2390083701 @default.
• W1937377332 cites W2468313363 @default.
• W1937377332 cites W992153260 @default.
• W1937377332 doi "https://doi.org/10.3978/j.issn.2072-1439.2014.04.09" @default.
• W1937377332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4073407" @default.
• W1937377332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24976992" @default.
• W1937377332 hasPublicationYear "2014" @default.
• W1937377332 type Work @default.
• W1937377332 sameAs 1937377332 @default.
• W1937377332 citedByCount "4" @default.
• W1937377332 countsByYear W19373773322015 @default.
• W1937377332 countsByYear W19373773322016 @default.
• W1937377332 countsByYear W19373773322022 @default.
• W1937377332 crossrefType "journal-article" @default.
• W1937377332 hasAuthorship W1937377332A5020473726 @default.
• W1937377332 hasAuthorship W1937377332A5033111915 @default.
• W1937377332 hasAuthorship W1937377332A5033166140 @default.
• W1937377332 hasAuthorship W1937377332A5044400067 @default.
• W1937377332 hasAuthorship W1937377332A5061529098 @default.
• W1937377332 hasConcept C104317684 @default.
• W1937377332 hasConcept C126322002 @default.
• W1937377332 hasConcept C143998085 @default.
• W1937377332 hasConcept C150194340 @default.
• W1937377332 hasConcept C156957248 @default.
• W1937377332 hasConcept C187960798 @default.
• W1937377332 hasConcept C190727270 @default.
• W1937377332 hasConcept C2776256026 @default.
• W1937377332 hasConcept C2780439572 @default.
• W1937377332 hasConcept C33288867 @default.
• W1937377332 hasConcept C44249647 @default.
• W1937377332 hasConcept C54355233 @default.
• W1937377332 hasConcept C60644358 @default.
• W1937377332 hasConcept C71924100 @default.
• W1937377332 hasConcept C82605166 @default.
• W1937377332 hasConcept C86803240 @default.
• W1937377332 hasConcept C95190672 @default.
• W1937377332 hasConceptScore W1937377332C104317684 @default.
• W1937377332 hasConceptScore W1937377332C126322002 @default.
• W1937377332 hasConceptScore W1937377332C143998085 @default.
• W1937377332 hasConceptScore W1937377332C150194340 @default.
• W1937377332 hasConceptScore W1937377332C156957248 @default.
• W1937377332 hasConceptScore W1937377332C187960798 @default.
• W1937377332 hasConceptScore W1937377332C190727270 @default.
• W1937377332 hasConceptScore W1937377332C2776256026 @default.
• W1937377332 hasConceptScore W1937377332C2780439572 @default.
• W1937377332 hasConceptScore W1937377332C33288867 @default.
• W1937377332 hasConceptScore W1937377332C44249647 @default.
• W1937377332 hasConceptScore W1937377332C54355233 @default.

• next