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• W1937556537 abstract "Many presynaptic transcripts have been observed in axons, yet their role in synapse development remains unknown. Using visually and pharmacologically isolated presynaptic terminals from dissociated rat hippocampal neurons, we found that ribosomes and β-catenin mRNA preferentially localize to recently formed boutons. Locally translated β-catenin accumulates at presynaptic terminals, where it regulates synaptic vesicle release dynamics. Thus, local translation of β-catenin is a newly described mechanism for axons to independently functionalize nerve terminals at great distances from cellular somata." @default.
• W1937556537 created "2016-06-24" @default.
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• W1937556537 date "2013-03-27" @default.
• W1937556537 modified "2023-10-16" @default.
• W1937556537 title "Axonal Translation of β-Catenin Regulates Synaptic Vesicle Dynamics" @default.
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• W1937556537 doi "https://doi.org/10.1523/jneurosci.2944-12.2013" @default.
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