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- W1937648813 abstract "Summary Three permanent human neoplastic cell strains were cultured in a fluid medium. Their reactions to elevated temperatures were studied. HeLa and J96 showed the same tolerance to heat, while H.Ep. #2 was more resistant. The three strains reacted to elevated temperatures at first with increased rate of growth (maximum at 38° C.), then with temporary interruption of the mitotic cycle in metaphase (39°–40° C.), finally with irreversible heat injury. The lethal exposure times were determined between 42° and 46° C. for single and divided heat application. The thermotolerance increased by culturing the cells at 39° C. previous to the experiment and was decreased by culturing them at 31° C. Cells surviving heat application became considerably more thermoresistant for at least 3 months. Sublines with higher thermotolerance were developed from all three strains. The morphologic changes during and after heat treatment were described." @default.
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- W1937648813 date "1957-09-01" @default.
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- W1937648813 title "Hyperthermia in tissue-cultured cells of malignant origin." @default.
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