Matches in SemOpenAlex for { <https://semopenalex.org/work/W193776670> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W193776670 endingPage "28" @default.
- W193776670 startingPage "316" @default.
- W193776670 abstract "The presence of organ-specific cell surface-reactive antibodies in sera of patients with autoimmune thyroid diseases (ATD) has been detected by indirect immunofluorescence on viable blood group O normal thyroid cultures. The cell surface determinants involved in this reaction have been identified as the thyroid 'microsomal' antigen which is thus also represented on the outer surface of the plasma membrane. The reactivity persists when F(ab')2 fragments from positive sera are used. Non-thyroid cells present in the monolayers, as well as human adrenal or fibroblast cultures, do not show positive staining. Human thyroid cells progressively lose both cell surface and intracytoplasmic antigenic components during the first week of culture. The exposure and reactivity of this antigen on the cell surface do not depend upon unmasking effects of proteolytic enzymes used for dispersal of the cells. The 'microsomal' antigen on the cell surface is also involved in the complement-mediated cytotoxic effect of sera from ATD patients on freshly dispersed thyroid cells. Thyroglobulin antibodies failed to stain viable thyroid monolayers, even when these were previously incubated with purified human thyroglobulin, indicating that this protein or possible receptors for it cannot be detected on the cell surface under these conditions. Similarly, some thyrotoxicosis sera containing thyroid-stimulating but not microsomal antibodies, gave negative reactions on viable cultures." @default.
- W193776670 created "2016-06-24" @default.
- W193776670 creator A5050144602 @default.
- W193776670 creator A5053325382 @default.
- W193776670 creator A5074002529 @default.
- W193776670 creator A5086922178 @default.
- W193776670 date "1981-08-01" @default.
- W193776670 modified "2023-10-12" @default.
- W193776670 title "Presence of the organ-specific 'microsomal' autoantigen on the surface of human thyroid cells in culture: its involvement in complement-mediated cytotoxicity." @default.
- W193776670 cites W110784347 @default.
- W193776670 cites W16497775 @default.
- W193776670 cites W1825238065 @default.
- W193776670 cites W1964998963 @default.
- W193776670 cites W1972983770 @default.
- W193776670 cites W1981721216 @default.
- W193776670 cites W1991139064 @default.
- W193776670 cites W1993582348 @default.
- W193776670 cites W1995481896 @default.
- W193776670 cites W2006470182 @default.
- W193776670 cites W2017118396 @default.
- W193776670 cites W2020588826 @default.
- W193776670 cites W2028517753 @default.
- W193776670 cites W2094843221 @default.
- W193776670 cites W2115265487 @default.
- W193776670 cites W2123144051 @default.
- W193776670 cites W21598861 @default.
- W193776670 cites W2395567291 @default.
- W193776670 cites W2405161369 @default.
- W193776670 cites W24780105 @default.
- W193776670 cites W2948847911 @default.
- W193776670 cites W73930879 @default.
- W193776670 cites W2405282088 @default.
- W193776670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1537363" @default.
- W193776670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6172224" @default.
- W193776670 hasPublicationYear "1981" @default.
- W193776670 type Work @default.
- W193776670 sameAs 193776670 @default.
- W193776670 citedByCount "83" @default.
- W193776670 countsByYear W1937766702015 @default.
- W193776670 countsByYear W1937766702021 @default.
- W193776670 crossrefType "journal-article" @default.
- W193776670 hasAuthorship W193776670A5050144602 @default.
- W193776670 hasAuthorship W193776670A5053325382 @default.
- W193776670 hasAuthorship W193776670A5074002529 @default.
- W193776670 hasAuthorship W193776670A5086922178 @default.
- W193776670 hasConcept C134018914 @default.
- W193776670 hasConcept C147483822 @default.
- W193776670 hasConcept C153911025 @default.
- W193776670 hasConcept C154317977 @default.
- W193776670 hasConcept C159654299 @default.
- W193776670 hasConcept C180650514 @default.
- W193776670 hasConcept C185592680 @default.
- W193776670 hasConcept C202751555 @default.
- W193776670 hasConcept C203014093 @default.
- W193776670 hasConcept C2778236600 @default.
- W193776670 hasConcept C2778835679 @default.
- W193776670 hasConcept C526584372 @default.
- W193776670 hasConcept C55493867 @default.
- W193776670 hasConcept C86803240 @default.
- W193776670 hasConceptScore W193776670C134018914 @default.
- W193776670 hasConceptScore W193776670C147483822 @default.
- W193776670 hasConceptScore W193776670C153911025 @default.
- W193776670 hasConceptScore W193776670C154317977 @default.
- W193776670 hasConceptScore W193776670C159654299 @default.
- W193776670 hasConceptScore W193776670C180650514 @default.
- W193776670 hasConceptScore W193776670C185592680 @default.
- W193776670 hasConceptScore W193776670C202751555 @default.
- W193776670 hasConceptScore W193776670C203014093 @default.
- W193776670 hasConceptScore W193776670C2778236600 @default.
- W193776670 hasConceptScore W193776670C2778835679 @default.
- W193776670 hasConceptScore W193776670C526584372 @default.
- W193776670 hasConceptScore W193776670C55493867 @default.
- W193776670 hasConceptScore W193776670C86803240 @default.
- W193776670 hasIssue "2" @default.
- W193776670 hasLocation W1937766701 @default.
- W193776670 hasOpenAccess W193776670 @default.
- W193776670 hasPrimaryLocation W1937766701 @default.
- W193776670 hasRelatedWork W111235939 @default.
- W193776670 hasRelatedWork W1963622860 @default.
- W193776670 hasRelatedWork W1966337757 @default.
- W193776670 hasRelatedWork W2008949385 @default.
- W193776670 hasRelatedWork W2141682087 @default.
- W193776670 hasRelatedWork W2235603914 @default.
- W193776670 hasRelatedWork W2397689420 @default.
- W193776670 hasRelatedWork W2412626621 @default.
- W193776670 hasRelatedWork W285239622 @default.
- W193776670 hasRelatedWork W339756260 @default.
- W193776670 hasVolume "45" @default.
- W193776670 isParatext "false" @default.
- W193776670 isRetracted "false" @default.
- W193776670 magId "193776670" @default.
- W193776670 workType "article" @default.