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- W193792010 abstract "1396 Objectives Although the overall specificity I-123 MIBG scintigraphy in detecting neuroblastoma is very high, it is not uncommon to recognize mild to moderate activity involving the adrenal gland in I-123 MIBG scan in the absence of definite anatomical abnormality. Up to this date, there has been no literature to explain this finding. The purpose of our study is to characterize this adrenal activity in correlation with anatomical imaging modality and clinical follow up. Methods Total of 30 patients (mean age 9, range 1-16) and total of 157 pediatric I-123 MIBG studies including planar and SPECT images from 2002 to 2010 were retrospectively reviewed (IRB approved). Each study was evaluated for the presence of adrenal MIBG avidity, location and the intensity. The intensity was graded as 0 (less than normal liver activity), 1 (equal to liver) and 2 (more than liver). The scintigraphic findings were correlated with diagnostic CT or MRI performed within 3 month from the point of I-123 MIBG study for the presence of any anatomical abnormality and with clinical follow up for average of 18 months for the progression/development of disease. Results Total of 19/30 (63%) patients and 69/157 (44%) studies were found to have positive adrenal activity. Out of 69 positive studies, only 3 studies (4% ) had corresponding anatomical adrenal masses and/or confirmed disease in follow up with average intensity grade of 0.8 and the rest (96 %) without definite anatomical findings in CT or MRI and/or the unremarkable follow up had average intensity grade of 1.3. 27 out of 69 studies (39 %) with positive findings had unilateral with more frequent on the left side (16/27, 59%) and 42/69 (61 %) had bilateral adrenal activity All 3 studies with abnormal anatomical finding had bilateral activity. Conclusions Most of the adrenal activity in I-123 MIBG study is found to be benign. The intensity or the unilaterality or bilaterality of adrenal activity is unlikely to be reliable parameters to be used to distinguish benign finding from malignant lesion" @default.
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- W193792010 date "2011-05-01" @default.
- W193792010 modified "2023-09-24" @default.
- W193792010 title "Characterization of adrenal activity in I-123 MIBG SPECT for pediatric neuroblastoma" @default.
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