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- W1937925701 abstract "Background: Airway obstruction in COPD is defined as FEV 1 /(F)VCl0.70 after broncho-dilator. There are hardly any population-based data evaluating the clinical impact of the pre- and post bronchodilator quotation. Aim: To compare subjects with pre- but not post respectively pre- and post bronchodilator quotation FEV 1 /(F)VCl0.70 in the population. Methods: In 2002-04 all previously examined subjects from four adult OLIN (Obstructive Lung disease in Northern Sweden) cohorts were invited to re-examination including spirometry and structured interview. All subjects with FEV 1 /best of FVC and VCl0.70 were identified (n=993). Clinical characteristics were based on interview data. Results: After bronchodilator 736 subjects had FEV 1 /(F)VCl0.70 and 257 had a quotation g0.70. Those with quotation l0.70 were older than those with quotation g0.70 (64.4 vs. 63.3, p=0.012). There were no significant differences in sex, prevalence ever smokers, allergic rhinitis, physician diagnosis of asthma before the age of 40 or exacerbations during the last 12 months between the groups. Prevalence of heart disease and cardiovascular disease was also similar. Reversibility, FEV 1 +12%&≥200ml, was significantly more common among those with quotation g0.70 (22.6 vs. 8.8%, pl0.001), while productive cough and chronic bronchitis was more common among those with quotation l0.70 (45.9 vs. 33.9% and 41.4 vs. 30.4%, p= 0.002 and 0.001). Conclusion: Subjects with pre- but not post-bronchodilator quotation l0.70 have similar characteristics as those with post-bronchodilator quotation l0.70, but they may include more asthmatics. Further, the fairly common bronchitis symptoms among them may be markers of risk to develop COPD." @default.
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- W1937925701 date "2014-09-01" @default.
- W1937925701 modified "2023-09-26" @default.
- W1937925701 title "The outcome of broncho-dilation among subjects with airway obstruction in the general population" @default.
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