FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938006118> ?p ?o ?g. }

• W1938006118 endingPage "8309" @default.
• W1938006118 startingPage "8301" @default.
• W1938006118 abstract "The importance of T-lymphocyte subsets in the control of poxvirus infections is controversial. To determine the relative contribution of lymphocyte subsets important for recovery from infection with ectromelia virus (EV), a natural murine poxvirus pathogen, C57BL/6 (B6) mice lacking functional CD8+ T cells because of disruption of the beta2-microglobulin gene or lacking functional CD4+ T cells because of disruption of the I-(A)beta gene, acutely depleted of CD8+ or CD4+ T cells with monoclonal antibody, or depleted of macrophage subsets by the macrophage suicide technique were used. Recovery from infection was strictly dependent on the effector functions of CD8+ T cells, in the absence of which 100% mortality resulted. This lymphocyte population had demonstrable antiviral activity early in the infection process even before class I major histocompatibility complex (MHC)-restricted CD8+ cytotoxic T-lymphocyte (CTL) activity was detectable. CD4+ T cells were found to be necessary for the generation of an optimal virus-specific, class I MHC-restricted CD8+ CTL response and contributed to virus clearance not involving cytolytic mechanisms. In both models of CD4+ T-cell deficiency, virus clearance was incomplete and persisted at low levels in most organs and at very high levels in the skin, but the animals did not die. The elimination of macrophage subpopulations impeded virus clearance, impaired the generation of class I MHC-restricted antiviral CTL response, and resulted in 100% mortality. These findings establish an absolute requirement for CD8+ and CD4+ T lymphocytes and macrophage subsets in the elimination of a natural murine poxvirus infection and support the idea that macrophages may be essential accessory cells for the generation of class I MHC-restricted antiviral CTL responses." @default.
• W1938006118 created "2016-06-24" @default.
• W1938006118 creator A5011122438 @default.
• W1938006118 creator A5022698027 @default.
• W1938006118 creator A5046304077 @default.
• W1938006118 creator A5079003683 @default.
• W1938006118 creator A5086688502 @default.
• W1938006118 date "1996-12-01" @default.
• W1938006118 modified "2023-09-27" @default.
• W1938006118 title "Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection" @default.
• W1938006118 cites W1408937249 @default.
• W1938006118 cites W1509443850 @default.
• W1938006118 cites W1510276262 @default.
• W1938006118 cites W1516245160 @default.
• W1938006118 cites W1546288178 @default.
• W1938006118 cites W1550534413 @default.
• W1938006118 cites W1559345047 @default.
• W1938006118 cites W1581704412 @default.
• W1938006118 cites W1669573844 @default.
• W1938006118 cites W1819121222 @default.
• W1938006118 cites W1850794279 @default.
• W1938006118 cites W1929946077 @default.
• W1938006118 cites W1936377377 @default.
• W1938006118 cites W1942668068 @default.
• W1938006118 cites W1968039269 @default.
• W1938006118 cites W1969937109 @default.
• W1938006118 cites W1972922050 @default.
• W1938006118 cites W1977409413 @default.
• W1938006118 cites W1989402394 @default.
• W1938006118 cites W1993677761 @default.
• W1938006118 cites W1995214747 @default.
• W1938006118 cites W1997563244 @default.
• W1938006118 cites W2010315866 @default.
• W1938006118 cites W2021516025 @default.
• W1938006118 cites W2040868302 @default.
• W1938006118 cites W2042487497 @default.
• W1938006118 cites W2054726996 @default.
• W1938006118 cites W2055111778 @default.
• W1938006118 cites W2057917981 @default.
• W1938006118 cites W2064706357 @default.
• W1938006118 cites W2067976882 @default.
• W1938006118 cites W2069125619 @default.
• W1938006118 cites W2073242046 @default.
• W1938006118 cites W2080537082 @default.
• W1938006118 cites W2085345039 @default.
• W1938006118 cites W2087165867 @default.
• W1938006118 cites W2090851364 @default.
• W1938006118 cites W2093143038 @default.
• W1938006118 cites W2095719190 @default.
• W1938006118 cites W2105523693 @default.
• W1938006118 cites W2109916423 @default.
• W1938006118 cites W2112923458 @default.
• W1938006118 cites W2126696395 @default.
• W1938006118 cites W2128942611 @default.
• W1938006118 cites W2140279098 @default.
• W1938006118 cites W2143777837 @default.
• W1938006118 cites W2155025120 @default.
• W1938006118 cites W2158500407 @default.
• W1938006118 cites W2158631781 @default.
• W1938006118 cites W2159580995 @default.
• W1938006118 cites W2177327503 @default.
• W1938006118 cites W2397967843 @default.
• W1938006118 cites W2417056087 @default.
• W1938006118 doi "https://doi.org/10.1128/jvi.70.12.8301-8309.1996" @default.
• W1938006118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/190917" @default.
• W1938006118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8970949" @default.
• W1938006118 hasPublicationYear "1996" @default.
• W1938006118 type Work @default.
• W1938006118 sameAs 1938006118 @default.
• W1938006118 citedByCount "163" @default.
• W1938006118 countsByYear W19380061182012 @default.
• W1938006118 countsByYear W19380061182013 @default.
• W1938006118 countsByYear W19380061182014 @default.
• W1938006118 countsByYear W19380061182015 @default.
• W1938006118 countsByYear W19380061182016 @default.
• W1938006118 countsByYear W19380061182017 @default.
• W1938006118 countsByYear W19380061182018 @default.
• W1938006118 countsByYear W19380061182019 @default.
• W1938006118 countsByYear W19380061182020 @default.
• W1938006118 countsByYear W19380061182021 @default.
• W1938006118 countsByYear W19380061182022 @default.
• W1938006118 crossrefType "journal-article" @default.
• W1938006118 hasAuthorship W1938006118A5011122438 @default.
• W1938006118 hasAuthorship W1938006118A5022698027 @default.
• W1938006118 hasAuthorship W1938006118A5046304077 @default.
• W1938006118 hasAuthorship W1938006118A5079003683 @default.
• W1938006118 hasAuthorship W1938006118A5086688502 @default.
• W1938006118 hasBestOaLocation W19380061181 @default.
• W1938006118 hasConcept C104317684 @default.
• W1938006118 hasConcept C144024400 @default.
• W1938006118 hasConcept C147969180 @default.
• W1938006118 hasConcept C149923435 @default.
• W1938006118 hasConcept C154317977 @default.
• W1938006118 hasConcept C159047783 @default.
• W1938006118 hasConcept C167672396 @default.
• W1938006118 hasConcept C170627219 @default.
• W1938006118 hasConcept C202751555 @default.
• W1938006118 hasConcept C203014093 @default.

• next