Matches in SemOpenAlex for { <https://semopenalex.org/work/W193814008> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W193814008 abstract "Introduction: The idiopathic inflammatory myopathies (IIM): dermatomyositis (DM) and polymyositis (PM) have been historically defined by broad clinical and pathological criteria. These conditions affect both adults and children with clinical features including muscle weakness, skin disease and internal organ involvement. Using a clinico-serological approach DM and PM can be defined into more homogeneous subsets. Myositis-specific autoantibodies (MSAs) are directed against cytoplasmic or nuclear components involved in key regulatory intra-cellular processes including protein synthesis, translocation and gene transcription. Over the last few years MSAs have been better characterised including autoantibodies directed against the aminoacyl tRNA-synthetase (ARS) enzymes, the signal recognition particle and the Mi-2 protein. Aim: The overall aim of this thesis is to describe a comprehensive clinical and serological study of adult and juvenile IIM. Autoantigen targets including novel specificities were identified using protein immunoprecipitation. Results: The first part of this thesis is a descriptive study on known myositis autoantibodies in adult IIM, confirming the significant association of interstitial pneumonia with anti-ARS, severe myopathy with anti-SRP, and classic DM with anti-Mi-2 serotype. In the next section, new autoantigen systems in adult IIM are described including a new anti-ARS (anti-Zo) in the anti-synthetase syndrome. Further autoantibodies directed against small ubiquitin-like modifier enzyme and a p155/140 autoantigen are major serological subsets in adult DM, the latter significantly associated with malignancy. The final section outlines a large serological study of juvenile DM (JDM) and JDM-overlap showing the frequency and clinical associations of MSAs and myositis-associated autoantibodies, including work on two new major subsets anti-p155/140 and anti-p140, which appear to define more severe disease. Conclusion: The work in this thesis highlights the importance of autoimmunity in IIM and suggests a new approach where MSAs can classify patients into clinical syndromes, which predict outcomes and may as a result influence treatment strategies." @default.
- W193814008 created "2016-06-24" @default.
- W193814008 creator A5018067681 @default.
- W193814008 date "2010-09-01" @default.
- W193814008 modified "2023-09-25" @default.
- W193814008 title "A clinical and serological study of adult and juvenile idiopathic inflammatory myopathy" @default.
- W193814008 hasPublicationYear "2010" @default.
- W193814008 type Work @default.
- W193814008 sameAs 193814008 @default.
- W193814008 citedByCount "0" @default.
- W193814008 crossrefType "dissertation" @default.
- W193814008 hasAuthorship W193814008A5018067681 @default.
- W193814008 hasConcept C142724271 @default.
- W193814008 hasConcept C159654299 @default.
- W193814008 hasConcept C163764329 @default.
- W193814008 hasConcept C203014093 @default.
- W193814008 hasConcept C2777300911 @default.
- W193814008 hasConcept C2778552304 @default.
- W193814008 hasConcept C2778751314 @default.
- W193814008 hasConcept C2779387793 @default.
- W193814008 hasConcept C2781232998 @default.
- W193814008 hasConcept C45189115 @default.
- W193814008 hasConcept C71924100 @default.
- W193814008 hasConceptScore W193814008C142724271 @default.
- W193814008 hasConceptScore W193814008C159654299 @default.
- W193814008 hasConceptScore W193814008C163764329 @default.
- W193814008 hasConceptScore W193814008C203014093 @default.
- W193814008 hasConceptScore W193814008C2777300911 @default.
- W193814008 hasConceptScore W193814008C2778552304 @default.
- W193814008 hasConceptScore W193814008C2778751314 @default.
- W193814008 hasConceptScore W193814008C2779387793 @default.
- W193814008 hasConceptScore W193814008C2781232998 @default.
- W193814008 hasConceptScore W193814008C45189115 @default.
- W193814008 hasConceptScore W193814008C71924100 @default.
- W193814008 hasLocation W1938140081 @default.
- W193814008 hasOpenAccess W193814008 @default.
- W193814008 hasPrimaryLocation W1938140081 @default.
- W193814008 hasRelatedWork W2004210750 @default.
- W193814008 hasRelatedWork W2015070712 @default.
- W193814008 hasRelatedWork W2027008114 @default.
- W193814008 hasRelatedWork W2045048491 @default.
- W193814008 hasRelatedWork W2069359556 @default.
- W193814008 hasRelatedWork W2088396501 @default.
- W193814008 hasRelatedWork W2097625974 @default.
- W193814008 hasRelatedWork W2107509312 @default.
- W193814008 hasRelatedWork W2147612783 @default.
- W193814008 hasRelatedWork W2164521943 @default.
- W193814008 hasRelatedWork W2166714841 @default.
- W193814008 hasRelatedWork W2238822973 @default.
- W193814008 hasRelatedWork W2423989695 @default.
- W193814008 hasRelatedWork W2516609763 @default.
- W193814008 hasRelatedWork W2586223089 @default.
- W193814008 hasRelatedWork W2590897159 @default.
- W193814008 hasRelatedWork W2797549582 @default.
- W193814008 hasRelatedWork W291436683 @default.
- W193814008 hasRelatedWork W3020853685 @default.
- W193814008 hasRelatedWork W3165822352 @default.
- W193814008 isParatext "false" @default.
- W193814008 isRetracted "false" @default.
- W193814008 magId "193814008" @default.
- W193814008 workType "dissertation" @default.