Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938176277> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W1938176277 abstract "Abstract Felbamate, a newly developed antiepileptic agent, has been demonstrated to control partial and generalized seizures effectively. We have developed a gas-chromatographic method for the determination of felbamate, using a wide-bore capillary column, a flame ionization detector, and a simple extraction procedure. The assay day-to-day precision (n = 20) was 5.2% and 3.6% for drug concentrations of 50 and 150 mg/L, respectively; average recovery over a wide range of felbamate concentrations was 95%; the detection limit was 5 mg/L; and assay linearity extended to 300 mg/L. Although 9 of the 27 drugs tested were coextracted with felbamate, they exhibited significantly different retention times and showed no interference. A short-term stability study showed that plasma felbamate is stable at 4, -20, or -78 degrees C for at least 1 month. Plasma felbamate concentrations in 66 pediatric patients ranged from 7 to 154 mg/L (mean +/- SD 44 +/- 24.7). We consider the method ideally suited for therapeutic monitoring of plasma felbamate concentration." @default.
- W1938176277 created "2016-06-24" @default.
- W1938176277 creator A5024218470 @default.
- W1938176277 creator A5029014154 @default.
- W1938176277 creator A5036362648 @default.
- W1938176277 creator A5067918995 @default.
- W1938176277 date "1994-05-01" @default.
- W1938176277 modified "2023-09-26" @default.
- W1938176277 title "Measurement of felbamate by wide-bore capillary gas chromatography and flame ionization detection" @default.
- W1938176277 doi "https://doi.org/10.1093/clinchem/40.5.745" @default.
- W1938176277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8174245" @default.
- W1938176277 hasPublicationYear "1994" @default.
- W1938176277 type Work @default.
- W1938176277 sameAs 1938176277 @default.
- W1938176277 citedByCount "13" @default.
- W1938176277 countsByYear W19381762772016 @default.
- W1938176277 countsByYear W19381762772021 @default.
- W1938176277 crossrefType "journal-article" @default.
- W1938176277 hasAuthorship W1938176277A5024218470 @default.
- W1938176277 hasAuthorship W1938176277A5029014154 @default.
- W1938176277 hasAuthorship W1938176277A5036362648 @default.
- W1938176277 hasAuthorship W1938176277A5067918995 @default.
- W1938176277 hasConcept C118552586 @default.
- W1938176277 hasConcept C119128265 @default.
- W1938176277 hasConcept C123460561 @default.
- W1938176277 hasConcept C171156812 @default.
- W1938176277 hasConcept C185592680 @default.
- W1938176277 hasConcept C2775858608 @default.
- W1938176277 hasConcept C2778186239 @default.
- W1938176277 hasConcept C2781011581 @default.
- W1938176277 hasConcept C43617362 @default.
- W1938176277 hasConcept C4725764 @default.
- W1938176277 hasConcept C71924100 @default.
- W1938176277 hasConceptScore W1938176277C118552586 @default.
- W1938176277 hasConceptScore W1938176277C119128265 @default.
- W1938176277 hasConceptScore W1938176277C123460561 @default.
- W1938176277 hasConceptScore W1938176277C171156812 @default.
- W1938176277 hasConceptScore W1938176277C185592680 @default.
- W1938176277 hasConceptScore W1938176277C2775858608 @default.
- W1938176277 hasConceptScore W1938176277C2778186239 @default.
- W1938176277 hasConceptScore W1938176277C2781011581 @default.
- W1938176277 hasConceptScore W1938176277C43617362 @default.
- W1938176277 hasConceptScore W1938176277C4725764 @default.
- W1938176277 hasConceptScore W1938176277C71924100 @default.
- W1938176277 hasLocation W19381762771 @default.
- W1938176277 hasLocation W19381762772 @default.
- W1938176277 hasOpenAccess W1938176277 @default.
- W1938176277 hasPrimaryLocation W19381762771 @default.
- W1938176277 hasRelatedWork W1992646321 @default.
- W1938176277 hasRelatedWork W2006539245 @default.
- W1938176277 hasRelatedWork W2014065942 @default.
- W1938176277 hasRelatedWork W2059338342 @default.
- W1938176277 hasRelatedWork W2100096104 @default.
- W1938176277 hasRelatedWork W2152336818 @default.
- W1938176277 hasRelatedWork W2355199891 @default.
- W1938176277 hasRelatedWork W2390132762 @default.
- W1938176277 hasRelatedWork W2735643771 @default.
- W1938176277 hasRelatedWork W3035319479 @default.
- W1938176277 isParatext "false" @default.
- W1938176277 isRetracted "false" @default.
- W1938176277 magId "1938176277" @default.
- W1938176277 workType "article" @default.