FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938295990> ?p ?o ?g. }

• W1938295990 endingPage "1140" @default.
• W1938295990 startingPage "1133" @default.
• W1938295990 abstract "The strongest genetic marker for psoriasis is Cw*06. Polymorphisms in the tumor necrosis factor (TNF)-alpha promoter region, especially replacement of guanine with adenine in positions -238 and -308 are related to higher TNF-alpha production and higher risk for psoriasis in Caucasoid populations, not found in Asians. We performed a case-control study of 69 patients with psoriasis type I and 70 controls, characterized clinical progression along 10-years of follow-up in mild or severe disease and determined HLA class I, II, and TNF single nucleotide polymorphisms (SNPs) -238 and -308 polymorphisms to demonstrate whether these polymorphisms may be genetic risk for susceptibility to psoriasis or severity of the disease in Brazilians.Polymorphisms were identified using PCR/SSP. Alleles, genotypes, and haplotypes frequencies were compared using Fisher's test.More severe disease was found in male patients. It may be suggested that alleles B*37, Cw*06, Cw*12, and DRB1*07 were associated with severe disease course, while B*57 with mild disease. No statistical difference was found between the patients and controls regarding polymorphisms frequencies in TNF SNPs. This study pointed to a higher TNF-238 G/G genotype frequency (OR: 3.21; CI: 1.06–9.71; P = 0.04) in the group with severe disease.Polymorphisms in the TNF-alpha SNPs do not seem to be a more important genetic risk factor for psoriasis than the already known Cw*06 in Brazilian patients, but these markers may be related to clinical manifestations." @default.
• W1938295990 created "2016-06-24" @default.
• W1938295990 creator A5014544565 @default.
• W1938295990 creator A5025786336 @default.
• W1938295990 creator A5046539511 @default.
• W1938295990 creator A5060594139 @default.
• W1938295990 creator A5061587246 @default.
• W1938295990 creator A5072462360 @default.
• W1938295990 creator A5074811414 @default.
• W1938295990 date "2010-09-28" @default.
• W1938295990 modified "2023-10-14" @default.
• W1938295990 title "Human leukocyte antigen (HLA) and single nucleotide polymorphisms (SNPs) tumor necrosis factor (TNF)-alpha -238 and -308 as genetic markers of susceptibility to psoriasis and severity of the disease in a long-term follow-up Brazilian study" @default.
• W1938295990 cites W1964995490 @default.
• W1938295990 cites W1965473023 @default.
• W1938295990 cites W1970477316 @default.
• W1938295990 cites W1974234610 @default.
• W1938295990 cites W1976974181 @default.
• W1938295990 cites W1983768730 @default.
• W1938295990 cites W1983810226 @default.
• W1938295990 cites W1993927129 @default.
• W1938295990 cites W1999763106 @default.
• W1938295990 cites W2000076767 @default.
• W1938295990 cites W2001420958 @default.
• W1938295990 cites W2013148771 @default.
• W1938295990 cites W2014388834 @default.
• W1938295990 cites W2025046126 @default.
• W1938295990 cites W2026418668 @default.
• W1938295990 cites W2036913768 @default.
• W1938295990 cites W2046279387 @default.
• W1938295990 cites W2048531476 @default.
• W1938295990 cites W2065885673 @default.
• W1938295990 cites W2083512980 @default.
• W1938295990 cites W2090665495 @default.
• W1938295990 cites W2103220838 @default.
• W1938295990 cites W2110755408 @default.
• W1938295990 cites W2117931579 @default.
• W1938295990 cites W2118094114 @default.
• W1938295990 cites W2119363359 @default.
• W1938295990 cites W2131239942 @default.
• W1938295990 cites W2146583983 @default.
• W1938295990 cites W2148126661 @default.
• W1938295990 cites W2154097633 @default.
• W1938295990 cites W2163521262 @default.
• W1938295990 cites W2164744373 @default.
• W1938295990 cites W2165641861 @default.
• W1938295990 cites W2171255147 @default.
• W1938295990 cites W4256351473 @default.
• W1938295990 doi "https://doi.org/10.1111/j.1365-4632.2010.04465.x" @default.
• W1938295990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20931685" @default.
• W1938295990 hasPublicationYear "2010" @default.
• W1938295990 type Work @default.
• W1938295990 sameAs 1938295990 @default.
• W1938295990 citedByCount "33" @default.
• W1938295990 countsByYear W19382959902012 @default.
• W1938295990 countsByYear W19382959902013 @default.
• W1938295990 countsByYear W19382959902014 @default.
• W1938295990 countsByYear W19382959902015 @default.
• W1938295990 countsByYear W19382959902016 @default.
• W1938295990 countsByYear W19382959902017 @default.
• W1938295990 countsByYear W19382959902018 @default.
• W1938295990 countsByYear W19382959902020 @default.
• W1938295990 countsByYear W19382959902021 @default.
• W1938295990 countsByYear W19382959902022 @default.
• W1938295990 countsByYear W19382959902023 @default.
• W1938295990 crossrefType "journal-article" @default.
• W1938295990 hasAuthorship W1938295990A5014544565 @default.
• W1938295990 hasAuthorship W1938295990A5025786336 @default.
• W1938295990 hasAuthorship W1938295990A5046539511 @default.
• W1938295990 hasAuthorship W1938295990A5060594139 @default.
• W1938295990 hasAuthorship W1938295990A5061587246 @default.
• W1938295990 hasAuthorship W1938295990A5072462360 @default.
• W1938295990 hasAuthorship W1938295990A5074811414 @default.
• W1938295990 hasConcept C104317684 @default.
• W1938295990 hasConcept C126322002 @default.
• W1938295990 hasConcept C135763542 @default.
• W1938295990 hasConcept C147483822 @default.
• W1938295990 hasConcept C153209595 @default.
• W1938295990 hasConcept C17991360 @default.
• W1938295990 hasConcept C180754005 @default.
• W1938295990 hasConcept C188280979 @default.
• W1938295990 hasConcept C197754878 @default.
• W1938295990 hasConcept C203014093 @default.
• W1938295990 hasConcept C2779134260 @default.
• W1938295990 hasConcept C2780564577 @default.
• W1938295990 hasConcept C37463918 @default.
• W1938295990 hasConcept C54355233 @default.
• W1938295990 hasConcept C71924100 @default.
• W1938295990 hasConcept C86803240 @default.
• W1938295990 hasConcept C90924648 @default.
• W1938295990 hasConceptScore W1938295990C104317684 @default.
• W1938295990 hasConceptScore W1938295990C126322002 @default.
• W1938295990 hasConceptScore W1938295990C135763542 @default.
• W1938295990 hasConceptScore W1938295990C147483822 @default.
• W1938295990 hasConceptScore W1938295990C153209595 @default.
• W1938295990 hasConceptScore W1938295990C17991360 @default.
• W1938295990 hasConceptScore W1938295990C180754005 @default.
• W1938295990 hasConceptScore W1938295990C188280979 @default.
• W1938295990 hasConceptScore W1938295990C197754878 @default.

• next