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• W1938491657 endingPage "401" @default.
• W1938491657 startingPage "388" @default.
• W1938491657 abstract "It is well known that many genes implicated in the development and progression of breast cancer undergo aberrant alternative splicing events to produce proteins with pro-cancer properties. These changes in alternative splicing can arise from mutations or single-nucleotide polymorphisms (SNPs) within the DNA sequences of cancer-related genes, which can strongly affect the activity of splicing factors and influence the splice site choice. However, it is important to note that absence of mutations is not sufficient to prevent misleading choices in splice site selection. There is now increasing evidence to demonstrate that the expression profile of ten splicing factors (including SRs and hnRNPs) and eight RNA-binding proteins changes in breast cancer cells compared with normal cells. These modifications strongly influence the alternative splicing pattern of many cancer-related genes despite the absence of any detrimental mutations within their DNA sequences. Thus, a comprehensive assessment of the splicing factor status in breast cancer is important to provide insights into the mechanisms that lead to breast cancer development and metastasis. Whilst most studies focus on mutations that affect alternative splicing in cancer-related genes, this review focuses on splicing factors and RNA-binding proteins that are themselves deregulated in breast cancer and implicated in cancer-related alternative splicing events." @default.
• W1938491657 created "2016-06-24" @default.
• W1938491657 creator A5053934618 @default.
• W1938491657 creator A5071424712 @default.
• W1938491657 creator A5086546843 @default.
• W1938491657 date "2015-05-05" @default.
• W1938491657 modified "2023-09-24" @default.
• W1938491657 title "Deregulation of splicing factors and breast cancer development" @default.
• W1938491657 cites W1507706498 @default.
• W1938491657 cites W1545715882 @default.
• W1938491657 cites W1552955399 @default.
• W1938491657 cites W1663251599 @default.
• W1938491657 cites W1965769379 @default.
• W1938491657 cites W1966211624 @default.
• W1938491657 cites W1969539383 @default.
• W1938491657 cites W1970108031 @default.
• W1938491657 cites W1971956957 @default.
• W1938491657 cites W1972011626 @default.
• W1938491657 cites W1973614363 @default.
• W1938491657 cites W1977145129 @default.
• W1938491657 cites W1980460136 @default.
• W1938491657 cites W1980768574 @default.
• W1938491657 cites W1982878502 @default.
• W1938491657 cites W1983061888 @default.
• W1938491657 cites W1986077139 @default.
• W1938491657 cites W1987944773 @default.
• W1938491657 cites W1989147967 @default.
• W1938491657 cites W1989336986 @default.
• W1938491657 cites W1989637941 @default.
• W1938491657 cites W1990628815 @default.
• W1938491657 cites W1991793186 @default.
• W1938491657 cites W1994680088 @default.
• W1938491657 cites W1996555072 @default.
• W1938491657 cites W1998462518 @default.
• W1938491657 cites W1999676514 @default.
• W1938491657 cites W1999728161 @default.
• W1938491657 cites W2000567082 @default.
• W1938491657 cites W2002995034 @default.
• W1938491657 cites W2005484266 @default.
• W1938491657 cites W2005929266 @default.
• W1938491657 cites W2006325063 @default.
• W1938491657 cites W2006423274 @default.
• W1938491657 cites W2006437549 @default.
• W1938491657 cites W2008962735 @default.
• W1938491657 cites W2010615446 @default.
• W1938491657 cites W2010852376 @default.
• W1938491657 cites W2011253545 @default.
• W1938491657 cites W2012843157 @default.
• W1938491657 cites W2014791263 @default.
• W1938491657 cites W2014856018 @default.
• W1938491657 cites W2016360721 @default.
• W1938491657 cites W2019226042 @default.
• W1938491657 cites W2027701384 @default.
• W1938491657 cites W2030669063 @default.
• W1938491657 cites W2032445038 @default.
• W1938491657 cites W2032646945 @default.
• W1938491657 cites W2035289183 @default.
• W1938491657 cites W2040481343 @default.
• W1938491657 cites W2041118375 @default.
• W1938491657 cites W2043435109 @default.
• W1938491657 cites W2045021854 @default.
• W1938491657 cites W2047088479 @default.
• W1938491657 cites W2047730969 @default.
• W1938491657 cites W2048255587 @default.
• W1938491657 cites W2048962172 @default.
• W1938491657 cites W2052772983 @default.
• W1938491657 cites W2056378496 @default.
• W1938491657 cites W2057358074 @default.
• W1938491657 cites W2058603087 @default.
• W1938491657 cites W2062672577 @default.
• W1938491657 cites W2063176993 @default.
• W1938491657 cites W2063318299 @default.
• W1938491657 cites W2063642745 @default.
• W1938491657 cites W2063800517 @default.
• W1938491657 cites W2063845207 @default.
• W1938491657 cites W2065572350 @default.
• W1938491657 cites W2066006328 @default.
• W1938491657 cites W2070933716 @default.
• W1938491657 cites W2071676184 @default.
• W1938491657 cites W2073683821 @default.
• W1938491657 cites W2073954801 @default.
• W1938491657 cites W2082491111 @default.
• W1938491657 cites W2087646012 @default.
• W1938491657 cites W2089738145 @default.
• W1938491657 cites W2090534984 @default.
• W1938491657 cites W2090632754 @default.
• W1938491657 cites W2092759184 @default.
• W1938491657 cites W2093391982 @default.
• W1938491657 cites W2093604269 @default.
• W1938491657 cites W2094867951 @default.
• W1938491657 cites W2097257853 @default.
• W1938491657 cites W2098010370 @default.
• W1938491657 cites W2098297062 @default.
• W1938491657 cites W2098516117 @default.
• W1938491657 cites W2098935052 @default.
• W1938491657 cites W2101636442 @default.
• W1938491657 cites W2102838147 @default.
• W1938491657 cites W2105461260 @default.

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