FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938518282> ?p ?o ?g. }

• W1938518282 endingPage "144" @default.
• W1938518282 startingPage "140" @default.
• W1938518282 abstract "Acetylcholinesterase (AChE) plays a key role in neurotransmission, in which it maintains the transmission of nerve impulses by catalyzing acetylcholine in the neuronal synapse. Acetylcholinesterase in Lepidoptera is encoded by two ace genes, ace1 and ace2. In this study, we used RNA interference to individually knock down the expression of ace1 or ace2 in a Bombyx mori (L.) (Lepidoptera: Bombycidae) cell line (BmN) to explore their functions and relationships. Knockdown efficiency was confirmed using quantitative real-time PCR. We also monitored transcription levels of ace1 and ace2 at different time points after B. mori nucleopolyhedrovirus (BmNPV) infection. We found that when the expression of ace1 was knocked down to 37.5%, the expression of ace2 increased by 66%; when ace2 expression was reduced to 33.4%, the ace1 expression was similarly reduced to 26.7%. Acetylcholinesterase activity was decreased to 86.2% when ace2 expression was inhibited. However, no significant difference was observed in AChE activity when ace1 expression was knocked down. After BmNPV infection, ace1 expression was gradually increasing, whereas ace2 expression was gradually decreasing. Our study indicates that ace2 plays an important compensatory role for the loss of ace1 in maintaining AChE activity by increasing its expression level. In addition, ace2 may also regulate transcription of ace1. Overall, our findings help elucidate the relationship between the two ace genes in Lepidoptera." @default.
• W1938518282 created "2016-06-24" @default.
• W1938518282 creator A5018551566 @default.
• W1938518282 creator A5019030260 @default.
• W1938518282 creator A5027373150 @default.
• W1938518282 creator A5028660883 @default.
• W1938518282 creator A5076758946 @default.
• W1938518282 creator A5080784518 @default.
• W1938518282 date "2012-01-04" @default.
• W1938518282 modified "2023-10-18" @default.
• W1938518282 title "Functional study of acetylcholinesterase genes in Bombyx mori ovary cells using RNA interference" @default.
• W1938518282 cites W1582929466 @default.
• W1938518282 cites W1822594710 @default.
• W1938518282 cites W1971048984 @default.
• W1938518282 cites W1982698806 @default.
• W1938518282 cites W1989549231 @default.
• W1938518282 cites W1990512275 @default.
• W1938518282 cites W1993341607 @default.
• W1938518282 cites W2001220230 @default.
• W1938518282 cites W2017641140 @default.
• W1938518282 cites W2025698813 @default.
• W1938518282 cites W2028316160 @default.
• W1938518282 cites W2031287050 @default.
• W1938518282 cites W2032887307 @default.
• W1938518282 cites W2045885021 @default.
• W1938518282 cites W2075171948 @default.
• W1938518282 cites W2076411145 @default.
• W1938518282 cites W2087418783 @default.
• W1938518282 cites W2091269327 @default.
• W1938518282 cites W2092848086 @default.
• W1938518282 cites W2094046596 @default.
• W1938518282 cites W2100829140 @default.
• W1938518282 cites W2104582743 @default.
• W1938518282 cites W2107277218 @default.
• W1938518282 cites W2153732050 @default.
• W1938518282 cites W2156667412 @default.
• W1938518282 cites W2160345222 @default.
• W1938518282 cites W2160986203 @default.
• W1938518282 doi "https://doi.org/10.1111/j.1570-7458.2011.01207.x" @default.
• W1938518282 hasPublicationYear "2012" @default.
• W1938518282 type Work @default.
• W1938518282 sameAs 1938518282 @default.
• W1938518282 citedByCount "9" @default.
• W1938518282 countsByYear W19385182822013 @default.
• W1938518282 countsByYear W19385182822014 @default.
• W1938518282 countsByYear W19385182822015 @default.
• W1938518282 countsByYear W19385182822016 @default.
• W1938518282 countsByYear W19385182822019 @default.
• W1938518282 countsByYear W19385182822023 @default.
• W1938518282 crossrefType "journal-article" @default.
• W1938518282 hasAuthorship W1938518282A5018551566 @default.
• W1938518282 hasAuthorship W1938518282A5019030260 @default.
• W1938518282 hasAuthorship W1938518282A5027373150 @default.
• W1938518282 hasAuthorship W1938518282A5028660883 @default.
• W1938518282 hasAuthorship W1938518282A5076758946 @default.
• W1938518282 hasAuthorship W1938518282A5080784518 @default.
• W1938518282 hasConcept C104317684 @default.
• W1938518282 hasConcept C138885662 @default.
• W1938518282 hasConcept C150194340 @default.
• W1938518282 hasConcept C153911025 @default.
• W1938518282 hasConcept C166703698 @default.
• W1938518282 hasConcept C173396325 @default.
• W1938518282 hasConcept C177756618 @default.
• W1938518282 hasConcept C179926584 @default.
• W1938518282 hasConcept C181199279 @default.
• W1938518282 hasConcept C18903297 @default.
• W1938518282 hasConcept C2777126123 @default.
• W1938518282 hasConcept C2778487026 @default.
• W1938518282 hasConcept C2778816929 @default.
• W1938518282 hasConcept C41895202 @default.
• W1938518282 hasConcept C55493867 @default.
• W1938518282 hasConcept C67705224 @default.
• W1938518282 hasConcept C86803240 @default.
• W1938518282 hasConcept C95444343 @default.
• W1938518282 hasConceptScore W1938518282C104317684 @default.
• W1938518282 hasConceptScore W1938518282C138885662 @default.
• W1938518282 hasConceptScore W1938518282C150194340 @default.
• W1938518282 hasConceptScore W1938518282C153911025 @default.
• W1938518282 hasConceptScore W1938518282C166703698 @default.
• W1938518282 hasConceptScore W1938518282C173396325 @default.
• W1938518282 hasConceptScore W1938518282C177756618 @default.
• W1938518282 hasConceptScore W1938518282C179926584 @default.
• W1938518282 hasConceptScore W1938518282C181199279 @default.
• W1938518282 hasConceptScore W1938518282C18903297 @default.
• W1938518282 hasConceptScore W1938518282C2777126123 @default.
• W1938518282 hasConceptScore W1938518282C2778487026 @default.
• W1938518282 hasConceptScore W1938518282C2778816929 @default.
• W1938518282 hasConceptScore W1938518282C41895202 @default.
• W1938518282 hasConceptScore W1938518282C55493867 @default.
• W1938518282 hasConceptScore W1938518282C67705224 @default.
• W1938518282 hasConceptScore W1938518282C86803240 @default.
• W1938518282 hasConceptScore W1938518282C95444343 @default.
• W1938518282 hasIssue "2" @default.
• W1938518282 hasLocation W19385182821 @default.
• W1938518282 hasOpenAccess W1938518282 @default.
• W1938518282 hasPrimaryLocation W19385182821 @default.
• W1938518282 hasRelatedWork W1490789589 @default.
• W1938518282 hasRelatedWork W1501667431 @default.

• next