Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938549961> ?p ?o ?g. }
- W1938549961 endingPage "3737" @default.
- W1938549961 startingPage "3729" @default.
- W1938549961 abstract "Drosophila development is coordinated by pulses of the steroid hormone 20-hydroxyecdysone (20E). During metamorphosis, the 20E-inducible Broad-Complex (BR-C) gene plays a key role in the genetic hierarchies that transduce the hormone signal, being required for the destruction of larval tissues and numerous aspects of adult development. Most of the known BR-C target genes, including the salivary gland secretion protein (Sgs) genes, are terminal differentiation genes that are thought to be directly regulated by BR-C-encoded transcription factors. Here, we show that repression of Sgs expression is indirectly controlled by the BR-C through transcriptional down-regulation of fork head, a tissue-specific gene that plays a central role in salivary gland development and is required for Sgs expression. Our results demonstrate that integration of a tissue-specific regulatory gene into a 20E-controlled genetic hierarchy provides a mechanism for hormonal repression. Furthermore, they suggest that the BR-C is placed at a different position within the 20E-controlled hierarchies than previously assumed, and that at least part of its pleiotropic functions are mediated by tissue-specific regulators." @default.
- W1938549961 created "2016-06-24" @default.
- W1938549961 creator A5028126772 @default.
- W1938549961 creator A5031259722 @default.
- W1938549961 creator A5035401168 @default.
- W1938549961 date "2001-10-01" @default.
- W1938549961 modified "2023-10-01" @default.
- W1938549961 title "Downregulation of the tissue-specific transcription factor Fork head by<i>Broad-Complex</i>mediates a stage-specific hormone response" @default.
- W1938549961 cites W126900397 @default.
- W1938549961 cites W1597247843 @default.
- W1938549961 cites W168881211 @default.
- W1938549961 cites W1909709288 @default.
- W1938549961 cites W1920119772 @default.
- W1938549961 cites W1969435183 @default.
- W1938549961 cites W1971727593 @default.
- W1938549961 cites W1971988151 @default.
- W1938549961 cites W1973231505 @default.
- W1938549961 cites W1976049591 @default.
- W1938549961 cites W1976851982 @default.
- W1938549961 cites W1981939829 @default.
- W1938549961 cites W1983951628 @default.
- W1938549961 cites W1989115298 @default.
- W1938549961 cites W2000517171 @default.
- W1938549961 cites W2011097763 @default.
- W1938549961 cites W2012970553 @default.
- W1938549961 cites W2013319978 @default.
- W1938549961 cites W2018466988 @default.
- W1938549961 cites W2018759259 @default.
- W1938549961 cites W2029701970 @default.
- W1938549961 cites W2042271211 @default.
- W1938549961 cites W2042965245 @default.
- W1938549961 cites W2046209045 @default.
- W1938549961 cites W2046218009 @default.
- W1938549961 cites W2051010405 @default.
- W1938549961 cites W2055734100 @default.
- W1938549961 cites W2058235418 @default.
- W1938549961 cites W2060116181 @default.
- W1938549961 cites W2064025098 @default.
- W1938549961 cites W2071640656 @default.
- W1938549961 cites W2073934947 @default.
- W1938549961 cites W2077281143 @default.
- W1938549961 cites W2080482028 @default.
- W1938549961 cites W2081910903 @default.
- W1938549961 cites W2082969720 @default.
- W1938549961 cites W2084940129 @default.
- W1938549961 cites W2088994478 @default.
- W1938549961 cites W2097978662 @default.
- W1938549961 cites W2101143531 @default.
- W1938549961 cites W2103116478 @default.
- W1938549961 cites W2106969664 @default.
- W1938549961 cites W2109284595 @default.
- W1938549961 cites W2110983797 @default.
- W1938549961 cites W2126084294 @default.
- W1938549961 cites W2129260844 @default.
- W1938549961 cites W2133681950 @default.
- W1938549961 cites W2136267625 @default.
- W1938549961 cites W2136838504 @default.
- W1938549961 cites W2138315073 @default.
- W1938549961 cites W2155984905 @default.
- W1938549961 cites W2165218504 @default.
- W1938549961 cites W2167194725 @default.
- W1938549961 cites W2167771120 @default.
- W1938549961 cites W2168933277 @default.
- W1938549961 cites W2171784464 @default.
- W1938549961 cites W2172256092 @default.
- W1938549961 cites W2183359569 @default.
- W1938549961 cites W2184627692 @default.
- W1938549961 cites W2231569610 @default.
- W1938549961 cites W2475382233 @default.
- W1938549961 cites W27330565 @default.
- W1938549961 doi "https://doi.org/10.1242/dev.128.19.3729" @default.
- W1938549961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11585799" @default.
- W1938549961 hasPublicationYear "2001" @default.
- W1938549961 type Work @default.
- W1938549961 sameAs 1938549961 @default.
- W1938549961 citedByCount "36" @default.
- W1938549961 countsByYear W19385499612013 @default.
- W1938549961 countsByYear W19385499612014 @default.
- W1938549961 countsByYear W19385499612015 @default.
- W1938549961 countsByYear W19385499612016 @default.
- W1938549961 countsByYear W19385499612020 @default.
- W1938549961 countsByYear W19385499612021 @default.
- W1938549961 crossrefType "journal-article" @default.
- W1938549961 hasAuthorship W1938549961A5028126772 @default.
- W1938549961 hasAuthorship W1938549961A5031259722 @default.
- W1938549961 hasAuthorship W1938549961A5035401168 @default.
- W1938549961 hasConcept C104317684 @default.
- W1938549961 hasConcept C138885662 @default.
- W1938549961 hasConcept C150194340 @default.
- W1938549961 hasConcept C165864922 @default.
- W1938549961 hasConcept C179926584 @default.
- W1938549961 hasConcept C186310378 @default.
- W1938549961 hasConcept C27153228 @default.
- W1938549961 hasConcept C2779324052 @default.
- W1938549961 hasConcept C41895202 @default.
- W1938549961 hasConcept C54355233 @default.
- W1938549961 hasConcept C86339819 @default.
- W1938549961 hasConcept C86803240 @default.