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• W1938553975 abstract "Luo W‐R, Gao F, Li S‐Y & Yao K‐T (2012) Histopathology Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma Aims: To detect the prognostic significance of tumour budding and its expression of aldehyde dehydrogenase 1 (ALDH1) in nasopharyngeal carcinoma (NPC). Methods and results: Tumour budding was investigated in 105 patients with NPC by immunohistochemistry for pan‐cytokeratin (AE1/AE3). The intensity of budding correlated strongly with T classification ( P = 0.008), lymphatic invasion ( P < 0.001), vascular invasion ( P = 0.029), lymph node metastasis ( P < 0.001), and clinical stage ( P = 0.010). Univariate analysis revealed that patients with high budding grade had poorer survival than those with low grade ( P = 0.002). Multivariate analysis showed that tumour budding was an independent predictor of survival ( P = 0.001). Furthermore, budding cells showed high‐level expression of the cancer stem cell (CSC) marker ALDH1. Budding cells with high‐level ALDH1 expression contributed to several aggressive behaviours and poor survival ( P = 0.000). Conclusions: We describe, for the first time, the presence of tumour budding and its correlation with aggressive tumour behaviour and poor patient survival in NPC. The degree of tumour budding could be a valuable predictive factor in NPC. In addition, we show, also for the first time, that budding cells in NPC might possess the invasive and metastatic properties of CSCs." @default.
• W1938553975 created "2016-06-24" @default.
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• W1938553975 date "2012-09-28" @default.
• W1938553975 modified "2023-10-16" @default.
• W1938553975 title "Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma" @default.
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• W1938553975 doi "https://doi.org/10.1111/j.1365-2559.2012.04350.x" @default.
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