FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W193860274> ?p ?o ?g. }

• W193860274 endingPage "94" @default.
• W193860274 startingPage "82" @default.
• W193860274 abstract "Transforming growth factor-beta 1 (TGF-beta 1) is generally considered to exert positive effects on the accumulation of extracellular matrices. These occur as the net result of enhanced matrix protein synthesis, diminished matrix metalloproteinase (MMP) synthesis, and augmented production of specific inhibitors, including the tissue inhibitor of metalloproteinases (TIMP-1). Given that glomerular TGF-beta 1 synthesis is induced by inflammation, the effects of this cytokine on synthesis of the 72-kd type IV collagenase and TIMP-1 by cultured human mesangial cells were evaluated. Concentrations of TGF-beta 1 of 5 ng/ml and above specifically stimulated the synthesis of the 72-kd type IV collagenase. This effect was independent of the stimulatory effect of TGF-beta 1 on TIMP-1 synthesis, which was maximal in a lower concentration range (0.1 to 1 ng/ml). Most significantly, the net effect at the higher concentrations of TGF-beta 1 was an excess of enzyme over the TIMP-1 inhibitor. Northern blot analysis of TGF-beta 1-stimulated human mesangial cells demonstrated a specific increase in the abundance of the 3.1 kb mRNA transcript encoding the 72-kd type IV collagenase, presumably mediated by a direct stimulation of 72-kd type IV collagenase mRNA transcription observed as early as 3 hours after exposure to TGF-beta 1. These studies were extended to an analysis of the expression of TGF-beta 1 and 72-kd type IV collagenase mRNAs in normal and nephritic rats. In normal animals, basal TGF-beta 1 and 72-kd type IV collagenase mRNA expression was observed in a strictly mesangial distribution. After induction of acute immune complex-mediated glomerulonephritis, there was a major increase in TGF-beta 1 and 72-kd type IV collagenase mRNA expression, which was strictly limited to the expanded, hypercellular mesangial compartment. Enhanced synthesis of the mesangial type IV collagenase in response to TGF-beta 1 released during glomerular inflammatory processes could have an important role in the extensive glomerular matrix remodeling that accompanies these disorders." @default.
• W193860274 created "2016-06-24" @default.
• W193860274 creator A5001829252 @default.
• W193860274 creator A5043052973 @default.
• W193860274 creator A5060225389 @default.
• W193860274 creator A5082597667 @default.
• W193860274 date "1994-01-01" @default.
• W193860274 modified "2023-10-16" @default.
• W193860274 title "Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase." @default.
• W193860274 cites W1510586846 @default.
• W193860274 cites W1550906650 @default.
• W193860274 cites W1558047875 @default.
• W193860274 cites W1565639874 @default.
• W193860274 cites W156759583 @default.
• W193860274 cites W1570035884 @default.
• W193860274 cites W1595561754 @default.
• W193860274 cites W1600110256 @default.
• W193860274 cites W1600220960 @default.
• W193860274 cites W1600831053 @default.
• W193860274 cites W1602004990 @default.
• W193860274 cites W1812969169 @default.
• W193860274 cites W1882182790 @default.
• W193860274 cites W1919700394 @default.
• W193860274 cites W1938499452 @default.
• W193860274 cites W1971878230 @default.
• W193860274 cites W1981808009 @default.
• W193860274 cites W1991693188 @default.
• W193860274 cites W1993851092 @default.
• W193860274 cites W1998156838 @default.
• W193860274 cites W2012034969 @default.
• W193860274 cites W2021562403 @default.
• W193860274 cites W2047156955 @default.
• W193860274 cites W2083968791 @default.
• W193860274 cites W2093586592 @default.
• W193860274 cites W2100778705 @default.
• W193860274 cites W2132668748 @default.
• W193860274 cites W2153549628 @default.
• W193860274 cites W2168476587 @default.
• W193860274 cites W2200390603 @default.
• W193860274 cites W225146660 @default.
• W193860274 cites W2296780006 @default.
• W193860274 cites W2324313576 @default.
• W193860274 cites W2344929644 @default.
• W193860274 cites W2418295165 @default.
• W193860274 cites W321009836 @default.
• W193860274 cites W4290134564 @default.
• W193860274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1887110" @default.
• W193860274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8291614" @default.
• W193860274 hasPublicationYear "1994" @default.
• W193860274 type Work @default.
• W193860274 sameAs 193860274 @default.
• W193860274 citedByCount "39" @default.
• W193860274 countsByYear W1938602742012 @default.
• W193860274 countsByYear W1938602742016 @default.
• W193860274 countsByYear W1938602742017 @default.
• W193860274 countsByYear W1938602742020 @default.
• W193860274 crossrefType "journal-article" @default.
• W193860274 hasAuthorship W193860274A5001829252 @default.
• W193860274 hasAuthorship W193860274A5043052973 @default.
• W193860274 hasAuthorship W193860274A5060225389 @default.
• W193860274 hasAuthorship W193860274A5082597667 @default.
• W193860274 hasConcept C104317684 @default.
• W193860274 hasConcept C105580179 @default.
• W193860274 hasConcept C109523444 @default.
• W193860274 hasConcept C118131993 @default.
• W193860274 hasConcept C126322002 @default.
• W193860274 hasConcept C134018914 @default.
• W193860274 hasConcept C153911025 @default.
• W193860274 hasConcept C177707886 @default.
• W193860274 hasConcept C181199279 @default.
• W193860274 hasConcept C185592680 @default.
• W193860274 hasConcept C189165786 @default.
• W193860274 hasConcept C2775965246 @default.
• W193860274 hasConcept C2776747403 @default.
• W193860274 hasConcept C2777107211 @default.
• W193860274 hasConcept C2778229498 @default.
• W193860274 hasConcept C2778394429 @default.
• W193860274 hasConcept C2778690821 @default.
• W193860274 hasConcept C2779131090 @default.
• W193860274 hasConcept C2779814568 @default.
• W193860274 hasConcept C2779851118 @default.
• W193860274 hasConcept C2780091579 @default.
• W193860274 hasConcept C2780644872 @default.
• W193860274 hasConcept C55493867 @default.
• W193860274 hasConcept C71924100 @default.
• W193860274 hasConcept C86803240 @default.
• W193860274 hasConceptScore W193860274C104317684 @default.
• W193860274 hasConceptScore W193860274C105580179 @default.
• W193860274 hasConceptScore W193860274C109523444 @default.
• W193860274 hasConceptScore W193860274C118131993 @default.
• W193860274 hasConceptScore W193860274C126322002 @default.
• W193860274 hasConceptScore W193860274C134018914 @default.
• W193860274 hasConceptScore W193860274C153911025 @default.
• W193860274 hasConceptScore W193860274C177707886 @default.
• W193860274 hasConceptScore W193860274C181199279 @default.
• W193860274 hasConceptScore W193860274C185592680 @default.
• W193860274 hasConceptScore W193860274C189165786 @default.
• W193860274 hasConceptScore W193860274C2775965246 @default.

• next