Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938693453> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1938693453 endingPage "502" @default.
- W1938693453 startingPage "496" @default.
- W1938693453 abstract "The postsynaptic effects of two aminoglycoside antibiotics, streptomycin and neomycin, were studied on miniature end-plate currents (mepcs) and acetylcholine-induced end-plate current fluctuations in voltage-clamped costocutaneous muscles of the garter snake (species Thamnophis). Neomycin decreased the amplitude of mepcs and accelerated the time constants of mepc decay in a concentration-dependent manner without altering the single exponential nature of mepc decay. Neomycin also produced a voltage- and concentration-dependent nonlinearity in the current/voltage relationship. The relationship between the time constants of mepc decay and membrane potential was progressively reduced with increasing concentrations of neomycin. A concentration-dependent reduction in single channel conductance and channel lifetime was also obtained with neomycin. In contrast, streptomycin, in concentrations up to 5 X 10(-5) M, did not significantly alter either mepc amplitude, the time constant of mepc decay, the relationship between the mepc decay time constant and membrane potential or the lifetime and conductance of single end-plate channels. In very high concentrations (greater than 1 mM) streptomycin decreased mepc amplitude and prolonged mepc decay at hyperpolarized membrane potentials. The results suggest that neomycin interacts with the ionic channels of the acetylcholine receptor in their open configuration, whereas streptomycin acts primarily by blocking the receptor. The significant differences in the molecular actions of these two antibiotics may provide an explanation for the observed differences in the character and reversal of the neuromuscular block produced by these antibiotics." @default.
- W1938693453 created "2016-06-24" @default.
- W1938693453 creator A5075104179 @default.
- W1938693453 date "1983-06-01" @default.
- W1938693453 modified "2023-10-03" @default.
- W1938693453 title "Effects of the aminoglycoside antibiotics, streptomycin and neomycin, on neuromuscular transmission. II. Postsynaptic considerations." @default.
- W1938693453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6306208" @default.
- W1938693453 hasPublicationYear "1983" @default.
- W1938693453 type Work @default.
- W1938693453 sameAs 1938693453 @default.
- W1938693453 citedByCount "30" @default.
- W1938693453 countsByYear W19386934532014 @default.
- W1938693453 countsByYear W19386934532019 @default.
- W1938693453 countsByYear W19386934532023 @default.
- W1938693453 crossrefType "journal-article" @default.
- W1938693453 hasAuthorship W1938693453A5075104179 @default.
- W1938693453 hasConcept C121332964 @default.
- W1938693453 hasConcept C121932024 @default.
- W1938693453 hasConcept C12554922 @default.
- W1938693453 hasConcept C170493617 @default.
- W1938693453 hasConcept C181911157 @default.
- W1938693453 hasConcept C185592680 @default.
- W1938693453 hasConcept C197341189 @default.
- W1938693453 hasConcept C26873012 @default.
- W1938693453 hasConcept C2775843808 @default.
- W1938693453 hasConcept C2775910092 @default.
- W1938693453 hasConcept C2777787772 @default.
- W1938693453 hasConcept C2779841869 @default.
- W1938693453 hasConcept C501593827 @default.
- W1938693453 hasConcept C55493867 @default.
- W1938693453 hasConcept C80161118 @default.
- W1938693453 hasConcept C86803240 @default.
- W1938693453 hasConcept C98274493 @default.
- W1938693453 hasConceptScore W1938693453C121332964 @default.
- W1938693453 hasConceptScore W1938693453C121932024 @default.
- W1938693453 hasConceptScore W1938693453C12554922 @default.
- W1938693453 hasConceptScore W1938693453C170493617 @default.
- W1938693453 hasConceptScore W1938693453C181911157 @default.
- W1938693453 hasConceptScore W1938693453C185592680 @default.
- W1938693453 hasConceptScore W1938693453C197341189 @default.
- W1938693453 hasConceptScore W1938693453C26873012 @default.
- W1938693453 hasConceptScore W1938693453C2775843808 @default.
- W1938693453 hasConceptScore W1938693453C2775910092 @default.
- W1938693453 hasConceptScore W1938693453C2777787772 @default.
- W1938693453 hasConceptScore W1938693453C2779841869 @default.
- W1938693453 hasConceptScore W1938693453C501593827 @default.
- W1938693453 hasConceptScore W1938693453C55493867 @default.
- W1938693453 hasConceptScore W1938693453C80161118 @default.
- W1938693453 hasConceptScore W1938693453C86803240 @default.
- W1938693453 hasConceptScore W1938693453C98274493 @default.
- W1938693453 hasIssue "3" @default.
- W1938693453 hasLocation W19386934531 @default.
- W1938693453 hasOpenAccess W1938693453 @default.
- W1938693453 hasPrimaryLocation W19386934531 @default.
- W1938693453 hasRelatedWork W1938693453 @default.
- W1938693453 hasRelatedWork W1968639255 @default.
- W1938693453 hasRelatedWork W1971794559 @default.
- W1938693453 hasRelatedWork W1973441149 @default.
- W1938693453 hasRelatedWork W1980795104 @default.
- W1938693453 hasRelatedWork W2035275045 @default.
- W1938693453 hasRelatedWork W2037003521 @default.
- W1938693453 hasRelatedWork W2043109700 @default.
- W1938693453 hasRelatedWork W2066774251 @default.
- W1938693453 hasRelatedWork W2089852836 @default.
- W1938693453 hasVolume "225" @default.
- W1938693453 isParatext "false" @default.
- W1938693453 isRetracted "false" @default.
- W1938693453 magId "1938693453" @default.
- W1938693453 workType "article" @default.