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• W1938698939 endingPage "860" @default.
• W1938698939 startingPage "850" @default.
• W1938698939 abstract "Hypermethylation is an important mechanism for the dynamic regulation of gene expression, necessary for metastasizing tumour cells. Our aim is to identify methylation tumour markers that have a predictive value for the presence of regional lymph node metastases in patients with oral and oropharyngeal squamous cell carcinoma (OOSCC). Significantly differentially expressed genes were retrieved from four reported microarray expression profiles comparing pN0 and pN+ head-neck tumours, and one expression array identifying functionally hypermethylated genes. Additional metastasis-associated genes were included from the literature. Thus genes were selected that influence the development of nodal metastases and might be regulated by methylation. Methylation-specific PCR (MSP) primers were designed and tested on 8 head-neck squamous cell carcinoma cell lines and technically validated on 10 formalin-fixed paraffin-embedded (FFPE) OOSCC cases. Predictive value was assessed in a clinical series of 70 FFPE OOSCC with pathologically determined nodal status. Five out of 28 methylation markers (OCLN, CDKN2A, MGMT, MLH1 and DAPK1) were frequently differentially methylated in OOSCC. Of these, MGMT methylation was associated with pN0 status (P = 0.02) and with lower immunoexpression (P = 0.02). DAPK1 methylation was associated with pN+ status (P = 0.008) but did not associate with protein expression. In conclusion, out of 28 candidate genes, two (7%) showed a predictive value for the pN status. Both genes, DAPK1 and MGMT, have predictive value for nodal metastasis in a clinical group of OOSCC. Therefore DNA methylation markers are capable of contributing to diagnosis and treatment selection in OOSCC. To efficiently identify additional new methylation markers, genome-wide methods are needed." @default.
• W1938698939 created "2016-06-24" @default.
• W1938698939 creator A5013562070 @default.
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• W1938698939 date "2015-07-25" @default.
• W1938698939 modified "2023-09-23" @default.
• W1938698939 title "Identification of methylation markers for the prediction of nodal metastasis in oral and oropharyngeal squamous cell carcinoma" @default.
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• W1938698939 cites W1924090634 @default.
• W1938698939 cites W1964350171 @default.
• W1938698939 cites W1965220537 @default.
• W1938698939 cites W1966850506 @default.
• W1938698939 cites W1968483633 @default.
• W1938698939 cites W1968528263 @default.
• W1938698939 cites W1970175320 @default.
• W1938698939 cites W1972068299 @default.
• W1938698939 cites W1981980694 @default.
• W1938698939 cites W1989252675 @default.
• W1938698939 cites W1994465394 @default.
• W1938698939 cites W1995387564 @default.
• W1938698939 cites W1995733666 @default.
• W1938698939 cites W1997806474 @default.
• W1938698939 cites W2002213101 @default.
• W1938698939 cites W2005145657 @default.
• W1938698939 cites W2006345816 @default.
• W1938698939 cites W2007247567 @default.
• W1938698939 cites W2016524159 @default.
• W1938698939 cites W2017562968 @default.
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• W1938698939 cites W2023908153 @default.
• W1938698939 cites W2029197798 @default.
• W1938698939 cites W2031871849 @default.
• W1938698939 cites W2039440242 @default.
• W1938698939 cites W2041686632 @default.
• W1938698939 cites W2045928184 @default.
• W1938698939 cites W2046371943 @default.
• W1938698939 cites W2047724911 @default.
• W1938698939 cites W2050333466 @default.
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• W1938698939 cites W2090416100 @default.
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• W1938698939 doi "https://doi.org/10.1080/15592294.2015.1075689" @default.
• W1938698939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4623460" @default.
• W1938698939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26213212" @default.
• W1938698939 hasPublicationYear "2015" @default.
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