FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938719884> ?p ?o ?g. }

• W1938719884 endingPage "320" @default.
• W1938719884 startingPage "308" @default.
• W1938719884 abstract "Melatonin is involved in the control of various physiological functions, such as sleep, cell growth and free radical scavenging. The ability of melatonin to behave as an antioxidant, together with the fact that the Alzheimer-related amyloid β-peptide (Aβ) triggers oxidative stress through hydroxyl radical-induced cell death, suggests that melatonin could reduce Alzheimer's pathology. Although the exact etiology of Alzheimer's disease (AD) remains to be established, excess Aβ is believed to be the primary contributor to the dysfunction and degeneration of neurons that occurs in AD. Aβ peptides are produced via the sequential cleavage of β-secretase β-site APP-cleaving enzyme 1 (BACE1) and γ-secretase (PS1/PS2), while α-secretase (ADAM10) prevents the production of Aβ peptides. We hypothesized that melatonin could inhibit BACE1 and PS1/PS2 and enhance ADAM10 expression. Using the human neuronal SH-SY5Y cell line, we found that melatonin inhibited BACE1 and PS1 and activated ADAM10 mRNA level and protein expression in a concentration-dependent manner and mediated via melatonin G protein-coupled receptors. Melatonin inhibits BACE1 and PS1 protein expressions through the attenuation of nuclear factor-κB phosphorylation (pNF-κB). Moreover, melatonin reduced BACE1 promoter transactivation and consequently downregulated β-secretase catalytic activity. The present data show that melatonin is not only a potential regulator of β/γ-secretase but also an activator of α-secretase expression through the activation of protein kinase C, thereby favoring the nonamyloidogenic pathway over the amyloidogenic pathway. Altogether, our findings suggest that melatonin may be a potential therapeutic agent for reducing the risk of AD in humans." @default.
• W1938719884 created "2016-06-24" @default.
• W1938719884 creator A5001163254 @default.
• W1938719884 creator A5008530342 @default.
• W1938719884 creator A5025346933 @default.
• W1938719884 creator A5030602183 @default.
• W1938719884 creator A5044451818 @default.
• W1938719884 creator A5052422297 @default.
• W1938719884 creator A5056441321 @default.
• W1938719884 creator A5069953764 @default.
• W1938719884 date "2015-07-18" @default.
• W1938719884 modified "2023-10-01" @default.
• W1938719884 title "Melatonin regulates the transcription of βAPP‐cleaving secretases mediated through melatonin receptors in human neuroblastoma SH‐SY5Y cells" @default.
• W1938719884 cites W1004850706 @default.
• W1938719884 cites W1510308646 @default.
• W1938719884 cites W1551503109 @default.
• W1938719884 cites W1567624342 @default.
• W1938719884 cites W1649036316 @default.
• W1938719884 cites W1825662655 @default.
• W1938719884 cites W1847017938 @default.
• W1938719884 cites W1967539903 @default.
• W1938719884 cites W1968786165 @default.
• W1938719884 cites W1972152229 @default.
• W1938719884 cites W1976262644 @default.
• W1938719884 cites W1981359936 @default.
• W1938719884 cites W1981831389 @default.
• W1938719884 cites W1987186278 @default.
• W1938719884 cites W1988151367 @default.
• W1938719884 cites W1988991201 @default.
• W1938719884 cites W1989791969 @default.
• W1938719884 cites W1993465897 @default.
• W1938719884 cites W1997202478 @default.
• W1938719884 cites W2003283600 @default.
• W1938719884 cites W2006386292 @default.
• W1938719884 cites W2008032082 @default.
• W1938719884 cites W2011332699 @default.
• W1938719884 cites W2015114583 @default.
• W1938719884 cites W2017959702 @default.
• W1938719884 cites W2018676032 @default.
• W1938719884 cites W2019461415 @default.
• W1938719884 cites W2019568649 @default.
• W1938719884 cites W2023717916 @default.
• W1938719884 cites W2029651747 @default.
• W1938719884 cites W2030843622 @default.
• W1938719884 cites W2031509851 @default.
• W1938719884 cites W2031661979 @default.
• W1938719884 cites W2034578135 @default.
• W1938719884 cites W2035176443 @default.
• W1938719884 cites W2036225615 @default.
• W1938719884 cites W2036839326 @default.
• W1938719884 cites W2038273154 @default.
• W1938719884 cites W2040170596 @default.
• W1938719884 cites W2041379622 @default.
• W1938719884 cites W2047507940 @default.
• W1938719884 cites W2048029392 @default.
• W1938719884 cites W2050630633 @default.
• W1938719884 cites W2054183594 @default.
• W1938719884 cites W2059008719 @default.
• W1938719884 cites W2063710444 @default.
• W1938719884 cites W2063991495 @default.
• W1938719884 cites W2069123379 @default.
• W1938719884 cites W2075664080 @default.
• W1938719884 cites W2077500590 @default.
• W1938719884 cites W2092917096 @default.
• W1938719884 cites W2098463951 @default.
• W1938719884 cites W2103440561 @default.
• W1938719884 cites W2107668207 @default.
• W1938719884 cites W2108648616 @default.
• W1938719884 cites W2109348594 @default.
• W1938719884 cites W2109727228 @default.
• W1938719884 cites W2116119567 @default.
• W1938719884 cites W2118539817 @default.
• W1938719884 cites W2118642813 @default.
• W1938719884 cites W2121823413 @default.
• W1938719884 cites W2123329342 @default.
• W1938719884 cites W2131181742 @default.
• W1938719884 cites W2131565097 @default.
• W1938719884 cites W2132810311 @default.
• W1938719884 cites W2133813372 @default.
• W1938719884 cites W2140607486 @default.
• W1938719884 cites W2142393219 @default.
• W1938719884 cites W2143771645 @default.
• W1938719884 cites W2154430571 @default.
• W1938719884 cites W2159558884 @default.
• W1938719884 cites W2162142126 @default.
• W1938719884 cites W4293247451 @default.
• W1938719884 doi "https://doi.org/10.1111/jpi.12260" @default.
• W1938719884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26123100" @default.
• W1938719884 hasPublicationYear "2015" @default.
• W1938719884 type Work @default.
• W1938719884 sameAs 1938719884 @default.
• W1938719884 citedByCount "41" @default.
• W1938719884 countsByYear W19387198842016 @default.
• W1938719884 countsByYear W19387198842017 @default.
• W1938719884 countsByYear W19387198842018 @default.
• W1938719884 countsByYear W19387198842019 @default.
• W1938719884 countsByYear W19387198842020 @default.
• W1938719884 countsByYear W19387198842021 @default.

• next