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• W1938734080 endingPage "4292" @default.
• W1938734080 startingPage "4280" @default.
• W1938734080 abstract "Cell surface metallo-endopeptidases play important roles in cell communication by controlling the levels of bioactive peptides around peptide receptors. To understand the relative relevance of these enzymes in the CNS, we characterized a metallo-endopeptidase in the CNS of Aplysia californica , whose peptidergic pathways are well described at the molecular, cellular, and physiological levels. The membrane-bound activity cleaved Leu-enkephalin at the Gly 3 –Phe 4 bond with an inhibitor profile similar to that of the mammalian neutral endopeptidase (NEP). This functional homology was supported by the molecular cloning of cDNAs from the CNS, which demonstrated that the Aplysia and mammalian NEPs share all the same amino acids that are essential for the enzymatic activity. The protein is recognized both by specific anti- Aplysia NEP (apNEP) antibodies and by the [ 125 I]-labeled NEP-specific inhibitor RB104, demonstrating that the apNEP gene codes for the RB104-binding protein. In situ hybridization experiments on sections of the ganglia of the CNS revealed that apNEP is expressed in neurons and that the mRNA is present both in the cell bodies and in neurites that travel along the neuropil and peripheral nerves. When incubated in the presence of a specific NEP inhibitor, many neurons of the buccal ganglion showed a greatly prolonged physiological response to stimulation, suggesting that NEP-like metallo-endopeptidases may play a critical role in the regulation of the feeding behavior in Aplysia . One of the putative targets of apNEP in this behavior is the small cardioactive peptide, as suggested by RP-HPLC experiments. More generally, the presence of apNEP in the CNS and periphery may indicate that it could play a major role in the modulation of synaptic transmission in Aplysia and in the metabolism of neuropeptides close to their point of release." @default.
• W1938734080 created "2016-06-24" @default.
• W1938734080 creator A5007121124 @default.
• W1938734080 creator A5059476929 @default.
• W1938734080 creator A5069230752 @default.
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• W1938734080 creator A5081980400 @default.
• W1938734080 creator A5084240535 @default.
• W1938734080 creator A5087626817 @default.
• W1938734080 date "1999-06-01" @default.
• W1938734080 modified "2023-10-10" @default.
• W1938734080 title "Cloning and Characterization of<i>Aplysia</i>Neutral Endopeptidase, a Metallo-Endopeptidase Involved in the Extracellular Metabolism of Neuropeptides in<i>Aplysia californica</i>" @default.
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