FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938761903> ?p ?o ?g. }

• W1938761903 endingPage "1011" @default.
• W1938761903 startingPage "1005" @default.
• W1938761903 abstract "Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Paeoniflorin, a natural product and active ingredient of Paeonia lactiflora, has been demonstrated to have many pharmacological effects including antiinflammatory and antihyperglycemic activity. We investigated the effects of paeoniflorin on NAFLD in mice and its underlying mechanisms. We examined this hypothesis using a well-established animal model of NAFLD. The effects of paeoniflorin on inflammation and glucolipid metabolism disorder were evaluated. The corresponding signaling pathways were measured using real-time polymerase chain reaction (PCR). We demonstrated that the mice developed obesity, dyslipidemia, and fatty liver, which formed the NAFLD model. Paeoniflorin attenuated NAFLD and exhibited potential cardiovascular protective effects in vivo by lowering body weight, hyperlipidemia, and insulin resistance; blocking inflammation; and inhibiting lipid ectopic deposition. Further investigation revealed that the antagonistic effect on hyperlipidemia and lipid ectopic deposition was related to lowering the lipid synthesis pathway (de novo pathway, 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG-CoAR)), promoting fatty acid oxidation [peroxisome proliferator-activated receptor-alpha (PPARα), carnitine palmitoyltransferase-1, etc.] and increasing cholesterol output (PPARγ-liver X receptor-α-ATP-binding cassette transporter-1); the inhibitory effects on inflammation and hyperglycemia were mediated by blocking inflammatory genes activation and reducing gluconeogenic genes expression (phosphoenolpyruvate carboxykinase and G6Pase). These results suggest that paeoniflorin prevents the development of NAFLD and reduces the risks of atherosclerosis through multiple intracellular signaling pathways. It may therefore be a potential therapeutic compound for NAFLD." @default.
• W1938761903 created "2016-06-24" @default.
• W1938761903 creator A5013931156 @default.
• W1938761903 creator A5051409818 @default.
• W1938761903 creator A5059823936 @default.
• W1938761903 date "2015-01-01" @default.
• W1938761903 modified "2023-10-17" @default.
• W1938761903 title "Paeoniflorin Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice" @default.
• W1938761903 cites W1523057616 @default.
• W1938761903 cites W1548938601 @default.
• W1938761903 cites W1975808053 @default.
• W1938761903 cites W1977936595 @default.
• W1938761903 cites W1992348905 @default.
• W1938761903 cites W2004409501 @default.
• W1938761903 cites W2022336568 @default.
• W1938761903 cites W2028887849 @default.
• W1938761903 cites W204032585 @default.
• W1938761903 cites W2045510035 @default.
• W1938761903 cites W2048457558 @default.
• W1938761903 cites W2050509217 @default.
• W1938761903 cites W2059103037 @default.
• W1938761903 cites W2066088297 @default.
• W1938761903 cites W2066136159 @default.
• W1938761903 cites W2066249010 @default.
• W1938761903 cites W2083052522 @default.
• W1938761903 cites W2084766254 @default.
• W1938761903 cites W2092162941 @default.
• W1938761903 cites W2093927266 @default.
• W1938761903 cites W2095591310 @default.
• W1938761903 cites W2102138165 @default.
• W1938761903 cites W2150762500 @default.
• W1938761903 cites W2171636224 @default.
• W1938761903 cites W2353014774 @default.
• W1938761903 cites W4230809943 @default.
• W1938761903 cites W79782691 @default.
• W1938761903 doi "https://doi.org/10.1248/bpb.b14-00892" @default.
• W1938761903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25972092" @default.
• W1938761903 hasPublicationYear "2015" @default.
• W1938761903 type Work @default.
• W1938761903 sameAs 1938761903 @default.
• W1938761903 citedByCount "54" @default.
• W1938761903 countsByYear W19387619032015 @default.
• W1938761903 countsByYear W19387619032016 @default.
• W1938761903 countsByYear W19387619032017 @default.
• W1938761903 countsByYear W19387619032018 @default.
• W1938761903 countsByYear W19387619032019 @default.
• W1938761903 countsByYear W19387619032020 @default.
• W1938761903 countsByYear W19387619032021 @default.
• W1938761903 countsByYear W19387619032022 @default.
• W1938761903 countsByYear W19387619032023 @default.
• W1938761903 crossrefType "journal-article" @default.
• W1938761903 hasAuthorship W1938761903A5013931156 @default.
• W1938761903 hasAuthorship W1938761903A5051409818 @default.
• W1938761903 hasAuthorship W1938761903A5059823936 @default.
• W1938761903 hasBestOaLocation W19387619031 @default.
• W1938761903 hasConcept C126322002 @default.
• W1938761903 hasConcept C134018914 @default.
• W1938761903 hasConcept C179998833 @default.
• W1938761903 hasConcept C185592680 @default.
• W1938761903 hasConcept C2776175330 @default.
• W1938761903 hasConcept C2776692505 @default.
• W1938761903 hasConcept C2776839432 @default.
• W1938761903 hasConcept C2776918747 @default.
• W1938761903 hasConcept C2776954865 @default.
• W1938761903 hasConcept C2777391703 @default.
• W1938761903 hasConcept C2778110834 @default.
• W1938761903 hasConcept C2778772119 @default.
• W1938761903 hasConcept C2779091943 @default.
• W1938761903 hasConcept C2779134260 @default.
• W1938761903 hasConcept C43617362 @default.
• W1938761903 hasConcept C4733338 @default.
• W1938761903 hasConcept C555293320 @default.
• W1938761903 hasConcept C71924100 @default.
• W1938761903 hasConcept C98274493 @default.
• W1938761903 hasConceptScore W1938761903C126322002 @default.
• W1938761903 hasConceptScore W1938761903C134018914 @default.
• W1938761903 hasConceptScore W1938761903C179998833 @default.
• W1938761903 hasConceptScore W1938761903C185592680 @default.
• W1938761903 hasConceptScore W1938761903C2776175330 @default.
• W1938761903 hasConceptScore W1938761903C2776692505 @default.
• W1938761903 hasConceptScore W1938761903C2776839432 @default.
• W1938761903 hasConceptScore W1938761903C2776918747 @default.
• W1938761903 hasConceptScore W1938761903C2776954865 @default.
• W1938761903 hasConceptScore W1938761903C2777391703 @default.
• W1938761903 hasConceptScore W1938761903C2778110834 @default.
• W1938761903 hasConceptScore W1938761903C2778772119 @default.
• W1938761903 hasConceptScore W1938761903C2779091943 @default.
• W1938761903 hasConceptScore W1938761903C2779134260 @default.
• W1938761903 hasConceptScore W1938761903C43617362 @default.
• W1938761903 hasConceptScore W1938761903C4733338 @default.
• W1938761903 hasConceptScore W1938761903C555293320 @default.
• W1938761903 hasConceptScore W1938761903C71924100 @default.
• W1938761903 hasConceptScore W1938761903C98274493 @default.
• W1938761903 hasIssue "7" @default.
• W1938761903 hasLocation W19387619031 @default.
• W1938761903 hasLocation W19387619032 @default.
• W1938761903 hasOpenAccess W1938761903 @default.
• W1938761903 hasPrimaryLocation W19387619031 @default.

• next