FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938807486> ?p ?o ?g. }

• W1938807486 endingPage "2066" @default.
• W1938807486 startingPage "2056" @default.
• W1938807486 abstract "Serving as the center for metabolism and detoxification, the liver is inherently susceptible to a wide variety of damage imposed by toxins or chemicals. Induction of cell populations with biliary epithelial phenotypes, which include progenitor‐like cells and are referred to as liver progenitor cells, is often observed in histopathological examination of various liver diseases in both human patients and animal models and has been implicated in regeneration. However, the tissue dynamics underlying this phenomenon remains largely unclear. We have developed a simple imaging technique to reveal the global and fine‐scale architecture of the biliary tract spreading in the mouse liver. Using this novel method, we show that the emergence and expansion of liver progenitor cells actually reflect structural transformation of the intrahepatic biliary tree in mouse liver injury models. The biliary branches expanded their area gradually and contiguously along with the course of chronic injury. Relevant regulatory signals known to be involved in liver progenitor cell regulation, including fibroblast growth factor 7 and tumor necrosis factor‐like weak inducer of apoptosis, can modulate the dynamics of the biliary epithelium in different ways. Importantly, the structural transformations of the biliary tree were diverse and corresponded well with the parenchymal injury patterns. That is, when chronic hepatocyte damage was induced in the pericentral area, the biliary branches exhibited an extended structure from the periportal area with apparent tropism toward the distant injured area. Conclusion : The hepatobiliary system possesses a unique and unprecedented structural flexibility and can remodel dynamically and adaptively in response to various injury conditions; this type of tissue plasticity should constitute an essential component to maintain liver homeostasis. (H epatology 2015;61:2056–2066)" @default.
• W1938807486 created "2016-06-24" @default.
• W1938807486 creator A5005500107 @default.
• W1938807486 creator A5016969792 @default.
• W1938807486 creator A5069121285 @default.
• W1938807486 creator A5078265862 @default.
• W1938807486 date "2015-04-22" @default.
• W1938807486 modified "2023-09-30" @default.
• W1938807486 title "Adaptive remodeling of the biliary architecture underlies liver homeostasis" @default.
• W1938807486 cites W1569761958 @default.
• W1938807486 cites W1605046073 @default.
• W1938807486 cites W1948254390 @default.
• W1938807486 cites W1968856828 @default.
• W1938807486 cites W1978135902 @default.
• W1938807486 cites W1989749181 @default.
• W1938807486 cites W1990765314 @default.
• W1938807486 cites W1999286197 @default.
• W1938807486 cites W2012545234 @default.
• W1938807486 cites W2012668509 @default.
• W1938807486 cites W2021283526 @default.
• W1938807486 cites W2023821363 @default.
• W1938807486 cites W2025966264 @default.
• W1938807486 cites W2038120192 @default.
• W1938807486 cites W2045541028 @default.
• W1938807486 cites W2045707643 @default.
• W1938807486 cites W2050689325 @default.
• W1938807486 cites W2053820570 @default.
• W1938807486 cites W2056510085 @default.
• W1938807486 cites W2068511028 @default.
• W1938807486 cites W2079404576 @default.
• W1938807486 cites W2084074847 @default.
• W1938807486 cites W2091305842 @default.
• W1938807486 cites W2091869893 @default.
• W1938807486 cites W2102869463 @default.
• W1938807486 cites W2105031631 @default.
• W1938807486 cites W2119277859 @default.
• W1938807486 cites W2124590862 @default.
• W1938807486 cites W2124782385 @default.
• W1938807486 cites W2131004746 @default.
• W1938807486 cites W2138908889 @default.
• W1938807486 cites W2151829576 @default.
• W1938807486 cites W2155189607 @default.
• W1938807486 cites W2170597152 @default.
• W1938807486 cites W2172643117 @default.
• W1938807486 doi "https://doi.org/10.1002/hep.27685" @default.
• W1938807486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25572923" @default.
• W1938807486 hasPublicationYear "2015" @default.
• W1938807486 type Work @default.
• W1938807486 sameAs 1938807486 @default.
• W1938807486 citedByCount "86" @default.
• W1938807486 countsByYear W19388074862015 @default.
• W1938807486 countsByYear W19388074862016 @default.
• W1938807486 countsByYear W19388074862017 @default.
• W1938807486 countsByYear W19388074862018 @default.
• W1938807486 countsByYear W19388074862019 @default.
• W1938807486 countsByYear W19388074862020 @default.
• W1938807486 countsByYear W19388074862021 @default.
• W1938807486 countsByYear W19388074862022 @default.
• W1938807486 countsByYear W19388074862023 @default.
• W1938807486 crossrefType "journal-article" @default.
• W1938807486 hasAuthorship W1938807486A5005500107 @default.
• W1938807486 hasAuthorship W1938807486A5016969792 @default.
• W1938807486 hasAuthorship W1938807486A5069121285 @default.
• W1938807486 hasAuthorship W1938807486A5078265862 @default.
• W1938807486 hasConcept C126322002 @default.
• W1938807486 hasConcept C134018914 @default.
• W1938807486 hasConcept C142724271 @default.
• W1938807486 hasConcept C15729860 @default.
• W1938807486 hasConcept C171056886 @default.
• W1938807486 hasConcept C201750760 @default.
• W1938807486 hasConcept C202751555 @default.
• W1938807486 hasConcept C2775982439 @default.
• W1938807486 hasConcept C2776200302 @default.
• W1938807486 hasConcept C2776637226 @default.
• W1938807486 hasConcept C2776795407 @default.
• W1938807486 hasConcept C28328180 @default.
• W1938807486 hasConcept C502942594 @default.
• W1938807486 hasConcept C55493867 @default.
• W1938807486 hasConcept C57322979 @default.
• W1938807486 hasConcept C71924100 @default.
• W1938807486 hasConcept C86803240 @default.
• W1938807486 hasConcept C95444343 @default.
• W1938807486 hasConceptScore W1938807486C126322002 @default.
• W1938807486 hasConceptScore W1938807486C134018914 @default.
• W1938807486 hasConceptScore W1938807486C142724271 @default.
• W1938807486 hasConceptScore W1938807486C15729860 @default.
• W1938807486 hasConceptScore W1938807486C171056886 @default.
• W1938807486 hasConceptScore W1938807486C201750760 @default.
• W1938807486 hasConceptScore W1938807486C202751555 @default.
• W1938807486 hasConceptScore W1938807486C2775982439 @default.
• W1938807486 hasConceptScore W1938807486C2776200302 @default.
• W1938807486 hasConceptScore W1938807486C2776637226 @default.
• W1938807486 hasConceptScore W1938807486C2776795407 @default.
• W1938807486 hasConceptScore W1938807486C28328180 @default.
• W1938807486 hasConceptScore W1938807486C502942594 @default.
• W1938807486 hasConceptScore W1938807486C55493867 @default.
• W1938807486 hasConceptScore W1938807486C57322979 @default.
• W1938807486 hasConceptScore W1938807486C71924100 @default.

• next