FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938861465> ?p ?o ?g. }

• W1938861465 endingPage "8" @default.
• W1938861465 startingPage "834" @default.
• W1938861465 abstract "Reactive oxygen species decrease dopamine transporter (DAT) function in vitro. Because of this, and the finding that METH administration causes oxygen radical formation in vivo, the effects of METH administration on DAT activity in rat striatum were investigated. A single METH injection caused a dose-dependent (0-15 mg/kg) decrease in [3H]dopamine uptake into striatal synaptosomes prepared 1 h after METH administration; an effect attributable to a decreased Vmax of [3H]dopamine uptake. Similarly, multiple high-dose administrations of METH (10 mg/kg/dose; four doses at 2-h intervals) decreased DAT function. The decreases in DAT activity after either single or multiple METH administrations were reversed 24 h after treatment. [3H]5HT transport into striatal synaptosomes was also affected by METH treatment. Taken together, these data suggest that METH decreases DAT activity, perhaps through a reactive oxygen species-mediated mechanism. These findings may have important implications regarding the role of oxidative events in the physiological regulation of monoaminergic systems." @default.
• W1938861465 created "2016-06-24" @default.
• W1938861465 creator A5012380785 @default.
• W1938861465 creator A5057713670 @default.
• W1938861465 creator A5074723102 @default.
• W1938861465 creator A5084096681 @default.
• W1938861465 creator A5090005130 @default.
• W1938861465 date "1997-08-01" @default.
• W1938861465 modified "2023-09-23" @default.
• W1938861465 title "Rapid and reversible effects of methamphetamine on dopamine transporters." @default.
• W1938861465 cites W1666261349 @default.
• W1938861465 cites W1975635801 @default.
• W1938861465 cites W1978363134 @default.
• W1938861465 cites W1981143827 @default.
• W1938861465 cites W1999977113 @default.
• W1938861465 cites W2002096394 @default.
• W1938861465 cites W2003622444 @default.
• W1938861465 cites W2004394508 @default.
• W1938861465 cites W2017577705 @default.
• W1938861465 cites W2032950110 @default.
• W1938861465 cites W2043803750 @default.
• W1938861465 cites W2047703381 @default.
• W1938861465 cites W2049495602 @default.
• W1938861465 cites W2061589525 @default.
• W1938861465 cites W2078031000 @default.
• W1938861465 cites W2104233676 @default.
• W1938861465 cites W2116022548 @default.
• W1938861465 cites W2142291145 @default.
• W1938861465 cites W2146904216 @default.
• W1938861465 cites W2154418626 @default.
• W1938861465 cites W2264173921 @default.
• W1938861465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9262348" @default.
• W1938861465 hasPublicationYear "1997" @default.
• W1938861465 type Work @default.
• W1938861465 sameAs 1938861465 @default.
• W1938861465 citedByCount "56" @default.
• W1938861465 countsByYear W19388614652012 @default.
• W1938861465 countsByYear W19388614652013 @default.
• W1938861465 countsByYear W19388614652014 @default.
• W1938861465 countsByYear W19388614652015 @default.
• W1938861465 countsByYear W19388614652016 @default.
• W1938861465 countsByYear W19388614652017 @default.
• W1938861465 countsByYear W19388614652018 @default.
• W1938861465 countsByYear W19388614652019 @default.
• W1938861465 countsByYear W19388614652020 @default.
• W1938861465 countsByYear W19388614652021 @default.
• W1938861465 countsByYear W19388614652022 @default.
• W1938861465 crossrefType "journal-article" @default.
• W1938861465 hasAuthorship W1938861465A5012380785 @default.
• W1938861465 hasAuthorship W1938861465A5057713670 @default.
• W1938861465 hasAuthorship W1938861465A5074723102 @default.
• W1938861465 hasAuthorship W1938861465A5084096681 @default.
• W1938861465 hasAuthorship W1938861465A5090005130 @default.
• W1938861465 hasConcept C126322002 @default.
• W1938861465 hasConcept C137183658 @default.
• W1938861465 hasConcept C150903083 @default.
• W1938861465 hasConcept C166940927 @default.
• W1938861465 hasConcept C170493617 @default.
• W1938861465 hasConcept C178790620 @default.
• W1938861465 hasConcept C185592680 @default.
• W1938861465 hasConcept C207001950 @default.
• W1938861465 hasConcept C2775864247 @default.
• W1938861465 hasConcept C2776755682 @default.
• W1938861465 hasConcept C2779989194 @default.
• W1938861465 hasConcept C2780062018 @default.
• W1938861465 hasConcept C2780114369 @default.
• W1938861465 hasConcept C2780376393 @default.
• W1938861465 hasConcept C42251903 @default.
• W1938861465 hasConcept C48349386 @default.
• W1938861465 hasConcept C513476851 @default.
• W1938861465 hasConcept C521977710 @default.
• W1938861465 hasConcept C55493867 @default.
• W1938861465 hasConcept C71924100 @default.
• W1938861465 hasConcept C86803240 @default.
• W1938861465 hasConcept C98274493 @default.
• W1938861465 hasConceptScore W1938861465C126322002 @default.
• W1938861465 hasConceptScore W1938861465C137183658 @default.
• W1938861465 hasConceptScore W1938861465C150903083 @default.
• W1938861465 hasConceptScore W1938861465C166940927 @default.
• W1938861465 hasConceptScore W1938861465C170493617 @default.
• W1938861465 hasConceptScore W1938861465C178790620 @default.
• W1938861465 hasConceptScore W1938861465C185592680 @default.
• W1938861465 hasConceptScore W1938861465C207001950 @default.
• W1938861465 hasConceptScore W1938861465C2775864247 @default.
• W1938861465 hasConceptScore W1938861465C2776755682 @default.
• W1938861465 hasConceptScore W1938861465C2779989194 @default.
• W1938861465 hasConceptScore W1938861465C2780062018 @default.
• W1938861465 hasConceptScore W1938861465C2780114369 @default.
• W1938861465 hasConceptScore W1938861465C2780376393 @default.
• W1938861465 hasConceptScore W1938861465C42251903 @default.
• W1938861465 hasConceptScore W1938861465C48349386 @default.
• W1938861465 hasConceptScore W1938861465C513476851 @default.
• W1938861465 hasConceptScore W1938861465C521977710 @default.
• W1938861465 hasConceptScore W1938861465C55493867 @default.
• W1938861465 hasConceptScore W1938861465C71924100 @default.
• W1938861465 hasConceptScore W1938861465C86803240 @default.
• W1938861465 hasConceptScore W1938861465C98274493 @default.
• W1938861465 hasIssue "2" @default.

• next