FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W19388958> ?p ?o ?g. }

• W19388958 endingPage "98" @default.
• W19388958 startingPage "93" @default.
• W19388958 abstract "Thrombopoietin (TPO), also known as the c-mpl ligand, stimulates rapid tyrosine phosphorylation of multiple proteins in human platelets including the Janus family kinases JAK2 and TYK2. On its own, TPO has no effect on platelet aggregation and dense-granule secretion but induces a general potentiation of these responses by other stimuli. The most dramatic effect is observed against threshold concentrations of agonists for aggregation. Shape change or weak reversible aggregation induced by low concentrations of thrombin, collagen and the thromboxane mimetic, U46619, are converted into irreversible aggregation in the presence of TPO. A similar result is obtained in the presence of the ADP scavenger apyrase and cyclo-oxygenase inhibitor indomethacin. TPO also induces potentiation of dense-granule secretion measured through release of 5-hydroxy[3H]-tryptamine. This effect is most striking against low concentrations of stimuli and is independent of aggregation as it is observed in the presence of chelation of extracellular Ca2+ with EGTA. TPO potentiates activation of phospholipase C and elevation of intracellular Ca2+, providing a molecular explanation for potentiation of functional responses. TPO may have an important physiological role in priming platelet activation in thrombocytopenia, an action that may help to compensate for the reduced platelet density." @default.
• W19388958 created "2016-06-24" @default.
• W19388958 creator A5057799772 @default.
• W19388958 creator A5058056421 @default.
• W19388958 date "1996-05-15" @default.
• W19388958 modified "2023-10-15" @default.
• W19388958 title "Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation" @default.
• W19388958 cites W125588914 @default.
• W19388958 cites W1507233793 @default.
• W19388958 cites W1523319406 @default.
• W19388958 cites W1535282081 @default.
• W19388958 cites W1571864484 @default.
• W19388958 cites W173282636 @default.
• W19388958 cites W1822167571 @default.
• W19388958 cites W1829315865 @default.
• W19388958 cites W1942718916 @default.
• W19388958 cites W1965375035 @default.
• W19388958 cites W1971731547 @default.
• W19388958 cites W1972927903 @default.
• W19388958 cites W1974656027 @default.
• W19388958 cites W1979959432 @default.
• W19388958 cites W1983612778 @default.
• W19388958 cites W1987686674 @default.
• W19388958 cites W1996093792 @default.
• W19388958 cites W1997632886 @default.
• W19388958 cites W1997785224 @default.
• W19388958 cites W2001643449 @default.
• W19388958 cites W2027286533 @default.
• W19388958 cites W2038818733 @default.
• W19388958 cites W2065810182 @default.
• W19388958 cites W2079440796 @default.
• W19388958 cites W2143531841 @default.
• W19388958 cites W2230842386 @default.
• W19388958 cites W2272820281 @default.
• W19388958 cites W2288224169 @default.
• W19388958 cites W2300796896 @default.
• W19388958 cites W2345238347 @default.
• W19388958 cites W2412348981 @default.
• W19388958 cites W29651041 @default.
• W19388958 cites W32095714 @default.
• W19388958 doi "https://doi.org/10.1042/bj3160093" @default.
• W19388958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1217355" @default.
• W19388958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8645238" @default.
• W19388958 hasPublicationYear "1996" @default.
• W19388958 type Work @default.
• W19388958 sameAs 19388958 @default.
• W19388958 citedByCount "60" @default.
• W19388958 countsByYear W193889582012 @default.
• W19388958 countsByYear W193889582013 @default.
• W19388958 countsByYear W193889582014 @default.
• W19388958 countsByYear W193889582015 @default.
• W19388958 countsByYear W193889582017 @default.
• W19388958 countsByYear W193889582018 @default.
• W19388958 countsByYear W193889582019 @default.
• W19388958 countsByYear W193889582021 @default.
• W19388958 countsByYear W193889582022 @default.
• W19388958 countsByYear W193889582023 @default.
• W19388958 crossrefType "journal-article" @default.
• W19388958 hasAuthorship W19388958A5057799772 @default.
• W19388958 hasAuthorship W19388958A5058056421 @default.
• W19388958 hasBestOaLocation W193889582 @default.
• W19388958 hasConcept C109159458 @default.
• W19388958 hasConcept C11960822 @default.
• W19388958 hasConcept C126322002 @default.
• W19388958 hasConcept C134018914 @default.
• W19388958 hasConcept C170493617 @default.
• W19388958 hasConcept C178790620 @default.
• W19388958 hasConcept C185592680 @default.
• W19388958 hasConcept C195794163 @default.
• W19388958 hasConcept C25274449 @default.
• W19388958 hasConcept C2776785769 @default.
• W19388958 hasConcept C2777553839 @default.
• W19388958 hasConcept C2777658833 @default.
• W19388958 hasConcept C2777863708 @default.
• W19388958 hasConcept C2779508331 @default.
• W19388958 hasConcept C2781024287 @default.
• W19388958 hasConcept C2781295650 @default.
• W19388958 hasConcept C28328180 @default.
• W19388958 hasConcept C28406088 @default.
• W19388958 hasConcept C3018697912 @default.
• W19388958 hasConcept C519063684 @default.
• W19388958 hasConcept C55493867 @default.
• W19388958 hasConcept C71924100 @default.
• W19388958 hasConcept C86803240 @default.
• W19388958 hasConcept C89560881 @default.
• W19388958 hasConcept C95444343 @default.
• W19388958 hasConceptScore W19388958C109159458 @default.
• W19388958 hasConceptScore W19388958C11960822 @default.
• W19388958 hasConceptScore W19388958C126322002 @default.
• W19388958 hasConceptScore W19388958C134018914 @default.
• W19388958 hasConceptScore W19388958C170493617 @default.
• W19388958 hasConceptScore W19388958C178790620 @default.
• W19388958 hasConceptScore W19388958C185592680 @default.
• W19388958 hasConceptScore W19388958C195794163 @default.
• W19388958 hasConceptScore W19388958C25274449 @default.
• W19388958 hasConceptScore W19388958C2776785769 @default.
• W19388958 hasConceptScore W19388958C2777553839 @default.
• W19388958 hasConceptScore W19388958C2777658833 @default.

• next