FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1938897610> ?p ?o ?g. }

• W1938897610 endingPage "483" @default.
• W1938897610 startingPage "473" @default.
• W1938897610 abstract "Introduction: Association of P2RY1 and P2RY12 polymorphisms with on-aspirin platelet reactivity was investigated. Materials and methods: Platelet reactivity was assessed by the light transmission aggregometry and TxB2 assay in 423 patients with coronary artery disease (CAD) on aspirin. High residual platelet reactivity (RPR) was defined by ≥20% and ≥70% maximal aggregation stimulated with 0.5 mg/mL arachidonic acid (AA) and 10 μm ADP, respectively. Moderate RPR was considered aggregation ≥20% with AA, ≥70% with ADP, or ≥1 ng/mL stimulated TxB2. Fourteen P2RY1 and 35 P2RY12 single nucleotide polymorphisms (SNPs) were genotyped. Results: High RPR was detected in 24% of the patients. Moderate RPR was observed in 31% with AA, 57% with 5 μm ADP, and 82% with 10 μm ADP. Stimulated TxB2 was ≥1 ng/mL in 23% of patients. P2RY12 SNP rs9859538 was associated with high RPR (OR = 2.16, 95% CI = 1.24–3.75, P-value = 0.004). Four P2RY12 SNPs, rs1491974, rs10513398, rs3732765, and rs10935841, showed association with moderate RPR (OR = 1.79–2.94, P-value = 0.04–0.028), while five, rs7615865, rs1388623, rs1388622, rs7634096, and rs7637803, were associated with low RPR (OR = 0.50–0.55, P-value = 0.008–0.026), following ADP stimulation. TxB2 level <1 ng/mL was linked to five P2RY1 SNPs, rs1439010, rs1371097, rs701265, rs12497578, and rs2312265 (OR = 0.36–0.54, P-value = 0.003–0.039). Conclusions: Polymorphisms in P2RY1 and P2RY12 are associated with on-aspirin platelet reactivity in patients with CAD." @default.
• W1938897610 created "2016-06-24" @default.
• W1938897610 creator A5010515168 @default.
• W1938897610 creator A5010571732 @default.
• W1938897610 creator A5022375331 @default.
• W1938897610 creator A5034006472 @default.
• W1938897610 creator A5047977017 @default.
• W1938897610 creator A5062010582 @default.
• W1938897610 creator A5066716873 @default.
• W1938897610 creator A5066788721 @default.
• W1938897610 creator A5067874747 @default.
• W1938897610 creator A5082018478 @default.
• W1938897610 date "2012-05-10" @default.
• W1938897610 modified "2023-10-18" @default.
• W1938897610 title "P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease" @default.
• W1938897610 cites W1553345686 @default.
• W1938897610 cites W1575525639 @default.
• W1938897610 cites W1608256683 @default.
• W1938897610 cites W1973236824 @default.
• W1938897610 cites W1976505948 @default.
• W1938897610 cites W1977566571 @default.
• W1938897610 cites W1988143463 @default.
• W1938897610 cites W1989615944 @default.
• W1938897610 cites W1993743428 @default.
• W1938897610 cites W2008732342 @default.
• W1938897610 cites W2009469799 @default.
• W1938897610 cites W2035401319 @default.
• W1938897610 cites W2039527993 @default.
• W1938897610 cites W2053379248 @default.
• W1938897610 cites W2056237991 @default.
• W1938897610 cites W2058971526 @default.
• W1938897610 cites W2075488948 @default.
• W1938897610 cites W2076597484 @default.
• W1938897610 cites W2096300961 @default.
• W1938897610 cites W2099380661 @default.
• W1938897610 cites W2100089051 @default.
• W1938897610 cites W2105735830 @default.
• W1938897610 cites W2129207263 @default.
• W1938897610 cites W2135336914 @default.
• W1938897610 cites W2136124501 @default.
• W1938897610 cites W2140261980 @default.
• W1938897610 cites W2144773588 @default.
• W1938897610 cites W2150912899 @default.
• W1938897610 cites W2152747528 @default.
• W1938897610 cites W2157752701 @default.
• W1938897610 cites W2161043271 @default.
• W1938897610 cites W42705460 @default.
• W1938897610 cites W4317527949 @default.
• W1938897610 doi "https://doi.org/10.1111/j.1751-553x.2012.01420.x" @default.
• W1938897610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3419334" @default.
• W1938897610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22574824" @default.
• W1938897610 hasPublicationYear "2012" @default.
• W1938897610 type Work @default.
• W1938897610 sameAs 1938897610 @default.
• W1938897610 citedByCount "31" @default.
• W1938897610 countsByYear W19388976102013 @default.
• W1938897610 countsByYear W19388976102014 @default.
• W1938897610 countsByYear W19388976102015 @default.
• W1938897610 countsByYear W19388976102016 @default.
• W1938897610 countsByYear W19388976102017 @default.
• W1938897610 countsByYear W19388976102018 @default.
• W1938897610 countsByYear W19388976102019 @default.
• W1938897610 countsByYear W19388976102020 @default.
• W1938897610 countsByYear W19388976102021 @default.
• W1938897610 countsByYear W19388976102022 @default.
• W1938897610 countsByYear W19388976102023 @default.
• W1938897610 crossrefType "journal-article" @default.
• W1938897610 hasAuthorship W1938897610A5010515168 @default.
• W1938897610 hasAuthorship W1938897610A5010571732 @default.
• W1938897610 hasAuthorship W1938897610A5022375331 @default.
• W1938897610 hasAuthorship W1938897610A5034006472 @default.
• W1938897610 hasAuthorship W1938897610A5047977017 @default.
• W1938897610 hasAuthorship W1938897610A5062010582 @default.
• W1938897610 hasAuthorship W1938897610A5066716873 @default.
• W1938897610 hasAuthorship W1938897610A5066788721 @default.
• W1938897610 hasAuthorship W1938897610A5067874747 @default.
• W1938897610 hasAuthorship W1938897610A5082018478 @default.
• W1938897610 hasBestOaLocation W19388976102 @default.
• W1938897610 hasConcept C104317684 @default.
• W1938897610 hasConcept C126322002 @default.
• W1938897610 hasConcept C135763542 @default.
• W1938897610 hasConcept C139275648 @default.
• W1938897610 hasConcept C142724271 @default.
• W1938897610 hasConcept C153209595 @default.
• W1938897610 hasConcept C181199279 @default.
• W1938897610 hasConcept C185592680 @default.
• W1938897610 hasConcept C2777628954 @default.
• W1938897610 hasConcept C2778078955 @default.
• W1938897610 hasConcept C2778213512 @default.
• W1938897610 hasConcept C55493867 @default.
• W1938897610 hasConcept C71924100 @default.
• W1938897610 hasConcept C89560881 @default.
• W1938897610 hasConcept C90924648 @default.
• W1938897610 hasConceptScore W1938897610C104317684 @default.
• W1938897610 hasConceptScore W1938897610C126322002 @default.
• W1938897610 hasConceptScore W1938897610C135763542 @default.
• W1938897610 hasConceptScore W1938897610C139275648 @default.
• W1938897610 hasConceptScore W1938897610C142724271 @default.

• next