Matches in SemOpenAlex for { <https://semopenalex.org/work/W1939457687> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1939457687 endingPage "9" @default.
- W1939457687 startingPage "1252" @default.
- W1939457687 abstract "To extend and confirm previous data, we examined the effects of raloxifene on the proximal tibia of ovariectomized rats, aged 6 months, longitudinally and cross-sectionally by computed tomography (pQCT) and then compared the effects to those of orally dosed estrogen. Comparative analysis of phantoms and rat bones showed that the pQCT is precise and correlates with a Hologic QDR 1000W (DXA) with R = 0.999 but is capable of measuring significant differences between groups when the DXA cannot. This may reflect the ability of the pQCT to determine bone volume, mineral content (mg) and volumetric mineral density (mg/cm3), compared with two-dimensional analyses performed with DXA. Longitudinal analysis of the proximal tibia in vivo showed a significant 17% reduction in mineral density 31 days after ovariectomy. Examination of the images from ovariectomized rats showed a progressive increase in the cross-sectional area of the proximal tibiae, loss of trabecular bone, widening of marrow spaces and thinning of the cortical bone wall opposite the fibula. Regression analysis of the dose-dependent protective effects of raloxifene showed the half-maximal efficacy on tibiae mineral density to be ED50 = 0.4 mg/kg/day per os by pQCT and 0.2 mg/kg/day by DXA. By comparison, 17 alpha ethynyl estradiol showed dose-dependent effects with ED50 = 0.013 mg/kg/day per os by pQCT. Both raloxifene and ethynyl estradiol had beneficial effects on serum lipids, producing 50% reduction of cholesterol at 0.1 mg/kg/day raloxifene and 80% reduction with 0.01 mg/kg/day ethynyl estradiol. However, raloxifene up to 10 mg/kg/day had little effect on uterine weight, whereas 0.01 mg/kg/day ethynyl estradiol increased uterine wet weight by 300%.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W1939457687 created "2016-06-24" @default.
- W1939457687 creator A5016105196 @default.
- W1939457687 creator A5023478435 @default.
- W1939457687 creator A5025166622 @default.
- W1939457687 creator A5032362159 @default.
- W1939457687 creator A5077677644 @default.
- W1939457687 date "1995-03-01" @default.
- W1939457687 modified "2023-09-23" @default.
- W1939457687 title "Longitudinal and cross-sectional analysis of raloxifene effects on tibiae from ovariectomized aged rats." @default.
- W1939457687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7891341" @default.
- W1939457687 hasPublicationYear "1995" @default.
- W1939457687 type Work @default.
- W1939457687 sameAs 1939457687 @default.
- W1939457687 citedByCount "42" @default.
- W1939457687 countsByYear W19394576872012 @default.
- W1939457687 countsByYear W19394576872014 @default.
- W1939457687 crossrefType "journal-article" @default.
- W1939457687 hasAuthorship W1939457687A5016105196 @default.
- W1939457687 hasAuthorship W1939457687A5023478435 @default.
- W1939457687 hasAuthorship W1939457687A5025166622 @default.
- W1939457687 hasAuthorship W1939457687A5032362159 @default.
- W1939457687 hasAuthorship W1939457687A5077677644 @default.
- W1939457687 hasConcept C105702510 @default.
- W1939457687 hasConcept C121608353 @default.
- W1939457687 hasConcept C126322002 @default.
- W1939457687 hasConcept C126894567 @default.
- W1939457687 hasConcept C134018914 @default.
- W1939457687 hasConcept C185592680 @default.
- W1939457687 hasConcept C2776541429 @default.
- W1939457687 hasConcept C2776886416 @default.
- W1939457687 hasConcept C2777164284 @default.
- W1939457687 hasConcept C2777236700 @default.
- W1939457687 hasConcept C2777425516 @default.
- W1939457687 hasConcept C2779329777 @default.
- W1939457687 hasConcept C2779889926 @default.
- W1939457687 hasConcept C2989005 @default.
- W1939457687 hasConcept C530470458 @default.
- W1939457687 hasConcept C71924100 @default.
- W1939457687 hasConcept C8264082 @default.
- W1939457687 hasConcept C84606932 @default.
- W1939457687 hasConceptScore W1939457687C105702510 @default.
- W1939457687 hasConceptScore W1939457687C121608353 @default.
- W1939457687 hasConceptScore W1939457687C126322002 @default.
- W1939457687 hasConceptScore W1939457687C126894567 @default.
- W1939457687 hasConceptScore W1939457687C134018914 @default.
- W1939457687 hasConceptScore W1939457687C185592680 @default.
- W1939457687 hasConceptScore W1939457687C2776541429 @default.
- W1939457687 hasConceptScore W1939457687C2776886416 @default.
- W1939457687 hasConceptScore W1939457687C2777164284 @default.
- W1939457687 hasConceptScore W1939457687C2777236700 @default.
- W1939457687 hasConceptScore W1939457687C2777425516 @default.
- W1939457687 hasConceptScore W1939457687C2779329777 @default.
- W1939457687 hasConceptScore W1939457687C2779889926 @default.
- W1939457687 hasConceptScore W1939457687C2989005 @default.
- W1939457687 hasConceptScore W1939457687C530470458 @default.
- W1939457687 hasConceptScore W1939457687C71924100 @default.
- W1939457687 hasConceptScore W1939457687C8264082 @default.
- W1939457687 hasConceptScore W1939457687C84606932 @default.
- W1939457687 hasIssue "3" @default.
- W1939457687 hasLocation W19394576871 @default.
- W1939457687 hasOpenAccess W1939457687 @default.
- W1939457687 hasPrimaryLocation W19394576871 @default.
- W1939457687 hasRelatedWork W1939457687 @default.
- W1939457687 hasRelatedWork W2044034581 @default.
- W1939457687 hasRelatedWork W2073621968 @default.
- W1939457687 hasRelatedWork W2075586630 @default.
- W1939457687 hasRelatedWork W2133849583 @default.
- W1939457687 hasRelatedWork W2138014802 @default.
- W1939457687 hasRelatedWork W2328878036 @default.
- W1939457687 hasRelatedWork W2374176073 @default.
- W1939457687 hasRelatedWork W2392394114 @default.
- W1939457687 hasRelatedWork W2751293203 @default.
- W1939457687 hasVolume "272" @default.
- W1939457687 isParatext "false" @default.
- W1939457687 isRetracted "false" @default.
- W1939457687 magId "1939457687" @default.
- W1939457687 workType "article" @default.