Matches in SemOpenAlex for { <https://semopenalex.org/work/W1939492712> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1939492712 abstract "KEIGI FUJIWARA, MICHITAKA MASUDA, MASAKI OSAWA, KAZUO KATOH, YUMIKO KANO, NOBORU HARADA, AND ROSANGELA B. LOPES Department of Structural Analysis, National Cardiovascular Center Research Institute, Suita, Osaka, 56.54565 Japan Fluid flow triggers a variety of responses in vascular endothelial cells (ECs), such as initiation of signal trans- duction, modulation of gene expression, and remodeling of cytoskeletal and related structures. However, the pri- mary steps of mechanosensing are not known. Because fluid flow is a mechanical (thus vectorial) stimulus, we decided to study how ECs respond in a vectorial manner. Among the various types of responses (for review, see Davies, 1995), those involving the cytoskeleton are clearly vectorial. Using a parallel plate flow chamber mounted on a light microscope, we first analyzed morphological responses of ECs to laminar flow (Masuda and Fujiwara, 1993a, b). We found that, in addition to the already known morpho- logical responses of ECs to flow (i.e., the elongation and alignment of ECs parallel to the direction of flow and alignment of stress fibers in the flow direction), flow in- duced preferential development of lamellipodia in the di- rection of flow. This latter response caused ECs to migrate preferentially in the flow direction. Although it takes many hours for both the cell shape change and the align- ment responses to become recognizable, the motility pat- tern change was detectable in 5 - 10 min. This is the fastest morphology-related response of ECs exposed to flow. ECs exhibit little morphologically detectable responses when exposed to fluid shear stress of less than 0.4 Pa (4 dyn/cm2), although it is known that many signal-transduc-" @default.
- W1939492712 created "2016-06-24" @default.
- W1939492712 creator A5004039760 @default.
- W1939492712 creator A5015054549 @default.
- W1939492712 creator A5024088703 @default.
- W1939492712 creator A5043069986 @default.
- W1939492712 creator A5052093582 @default.
- W1939492712 creator A5061765991 @default.
- W1939492712 creator A5082906811 @default.
- W1939492712 date "1998-06-01" @default.
- W1939492712 modified "2023-09-25" @default.
- W1939492712 title "Response of Vascular Endothelial Cells to Fluid Flow" @default.
- W1939492712 cites W1936770188 @default.
- W1939492712 cites W1965676120 @default.
- W1939492712 cites W1996592714 @default.
- W1939492712 cites W2017014860 @default.
- W1939492712 cites W2028992011 @default.
- W1939492712 cites W2066846310 @default.
- W1939492712 cites W2473357202 @default.
- W1939492712 doi "https://doi.org/10.2307/1543120" @default.
- W1939492712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9664669" @default.
- W1939492712 hasPublicationYear "1998" @default.
- W1939492712 type Work @default.
- W1939492712 sameAs 1939492712 @default.
- W1939492712 citedByCount "3" @default.
- W1939492712 crossrefType "journal-article" @default.
- W1939492712 hasAuthorship W1939492712A5004039760 @default.
- W1939492712 hasAuthorship W1939492712A5015054549 @default.
- W1939492712 hasAuthorship W1939492712A5024088703 @default.
- W1939492712 hasAuthorship W1939492712A5043069986 @default.
- W1939492712 hasAuthorship W1939492712A5052093582 @default.
- W1939492712 hasAuthorship W1939492712A5061765991 @default.
- W1939492712 hasAuthorship W1939492712A5082906811 @default.
- W1939492712 hasConcept C105702510 @default.
- W1939492712 hasConcept C112950240 @default.
- W1939492712 hasConcept C121332964 @default.
- W1939492712 hasConcept C12554922 @default.
- W1939492712 hasConcept C142669718 @default.
- W1939492712 hasConcept C1491633281 @default.
- W1939492712 hasConcept C191897082 @default.
- W1939492712 hasConcept C192562407 @default.
- W1939492712 hasConcept C21141959 @default.
- W1939492712 hasConcept C33947775 @default.
- W1939492712 hasConcept C55493867 @default.
- W1939492712 hasConcept C57879066 @default.
- W1939492712 hasConcept C58207958 @default.
- W1939492712 hasConcept C76563973 @default.
- W1939492712 hasConcept C86803240 @default.
- W1939492712 hasConcept C95444343 @default.
- W1939492712 hasConceptScore W1939492712C105702510 @default.
- W1939492712 hasConceptScore W1939492712C112950240 @default.
- W1939492712 hasConceptScore W1939492712C121332964 @default.
- W1939492712 hasConceptScore W1939492712C12554922 @default.
- W1939492712 hasConceptScore W1939492712C142669718 @default.
- W1939492712 hasConceptScore W1939492712C1491633281 @default.
- W1939492712 hasConceptScore W1939492712C191897082 @default.
- W1939492712 hasConceptScore W1939492712C192562407 @default.
- W1939492712 hasConceptScore W1939492712C21141959 @default.
- W1939492712 hasConceptScore W1939492712C33947775 @default.
- W1939492712 hasConceptScore W1939492712C55493867 @default.
- W1939492712 hasConceptScore W1939492712C57879066 @default.
- W1939492712 hasConceptScore W1939492712C58207958 @default.
- W1939492712 hasConceptScore W1939492712C76563973 @default.
- W1939492712 hasConceptScore W1939492712C86803240 @default.
- W1939492712 hasConceptScore W1939492712C95444343 @default.
- W1939492712 hasLocation W19394927121 @default.
- W1939492712 hasLocation W19394927122 @default.
- W1939492712 hasOpenAccess W1939492712 @default.
- W1939492712 hasPrimaryLocation W19394927121 @default.
- W1939492712 hasRelatedWork W2066059272 @default.
- W1939492712 hasRelatedWork W2082860237 @default.
- W1939492712 hasRelatedWork W2119695867 @default.
- W1939492712 hasRelatedWork W2123776778 @default.
- W1939492712 hasRelatedWork W2183072594 @default.
- W1939492712 hasRelatedWork W2357525786 @default.
- W1939492712 hasRelatedWork W2444319756 @default.
- W1939492712 hasRelatedWork W2945418960 @default.
- W1939492712 hasRelatedWork W3196212526 @default.
- W1939492712 hasRelatedWork W4246009453 @default.
- W1939492712 isParatext "false" @default.
- W1939492712 isRetracted "false" @default.
- W1939492712 magId "1939492712" @default.
- W1939492712 workType "article" @default.