FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1939559612> ?p ?o ?g. }

• W1939559612 endingPage "92" @default.
• W1939559612 startingPage "85" @default.
• W1939559612 abstract "The time course of hepatic zinc-isometallothionein synthesis was studied in the regenerating liver and compared with that produced after the parenteral injection of zinc (6 mg of Zn2+/kg). In the regenerating liver, zinc levels rose rapidly after partial hepatectomy and reached a maximum at approx. 14h before declining to approximately normal levels at 48h post-operation. During this 48h period most of the zinc was incorporated into metallothionein. Purification of the latter into the charge-separable isometallothioneins (i.e. MT1 and MT2) showed that, in the regenerating liver, there was an unequal distribution of zinc between the two isoproteins. Thus at operation the endogenous thionein had an MT2/MT1 ratio of 1; after regeneration this ratio increased, and all times during the time course there was more MT2 than MT1. In contrast, the intraperitoneal injection of zinc produced a biphasic uptake of zinc into the liver with maxima at 10h and 32h. During the first phase of zinc uptake, metallothionein synthesis increased rapidly and, unlike the regenerating liver, the MT2/MT1 ratio of 1 remained constant. Thereafter, this ratio increased in a manner analogous to that exhibited by the regenerating liver. Half-life determinations for thionein disappearance/degradation shows that MT2 and MT1 were degraded with half-lives (t1/2) of 26.18h and 16.44h respectively in the regenerating liver and 14.75h and 9.3h after zinc injection. Thus thionein disappearance/degradation in the regenerating liver was slower than that seen after zinc injection. However, in both situations MT2 was always removed at a slower rate than MT1. Calculation of the rates of thionein synthesis (assuming the above disappearance rates were constant throughout the time course) showed that, in the regenerating liver, the rate of MT2 synthesis was approximately twice that of MT1. This was not the case after zinc injection, where both isometallothioneins were synthesized in equal amounts. These results demonstrate that the rates of synthesis of MT2 and MT1 can be altered according to the metabolic status of the cell and suggest a specific role for MT2 during liver regeneration." @default.
• W1939559612 created "2016-06-24" @default.
• W1939559612 creator A5026241131 @default.
• W1939559612 creator A5036733963 @default.
• W1939559612 date "1984-01-01" @default.
• W1939559612 modified "2023-09-26" @default.
• W1939559612 title "A comparison of isometallothionein synthesis in rat liver after partial hepatectomy and parenteral zinc injection" @default.
• W1939559612 cites W1504648808 @default.
• W1939559612 cites W1532403085 @default.
• W1939559612 cites W1839823486 @default.
• W1939559612 cites W1964434964 @default.
• W1939559612 cites W2000140656 @default.
• W1939559612 cites W2031987047 @default.
• W1939559612 cites W2054096537 @default.
• W1939559612 cites W2064329283 @default.
• W1939559612 cites W2072088126 @default.
• W1939559612 cites W2086846746 @default.
• W1939559612 cites W2211753567 @default.
• W1939559612 cites W2239518884 @default.
• W1939559612 cites W2267755726 @default.
• W1939559612 cites W2280419437 @default.
• W1939559612 cites W2290088626 @default.
• W1939559612 cites W2341400372 @default.
• W1939559612 cites W2397446834 @default.
• W1939559612 cites W2403293081 @default.
• W1939559612 cites W2417275421 @default.
• W1939559612 cites W289754565 @default.
• W1939559612 doi "https://doi.org/10.1042/bj2170085" @default.
• W1939559612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1153185" @default.
• W1939559612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6696733" @default.
• W1939559612 hasPublicationYear "1984" @default.
• W1939559612 type Work @default.
• W1939559612 sameAs 1939559612 @default.
• W1939559612 citedByCount "53" @default.
• W1939559612 crossrefType "journal-article" @default.
• W1939559612 hasAuthorship W1939559612A5026241131 @default.
• W1939559612 hasAuthorship W1939559612A5036733963 @default.
• W1939559612 hasBestOaLocation W19395596122 @default.
• W1939559612 hasConcept C126322002 @default.
• W1939559612 hasConcept C134018914 @default.
• W1939559612 hasConcept C141071460 @default.
• W1939559612 hasConcept C159110652 @default.
• W1939559612 hasConcept C16613235 @default.
• W1939559612 hasConcept C171056886 @default.
• W1939559612 hasConcept C177322064 @default.
• W1939559612 hasConcept C178790620 @default.
• W1939559612 hasConcept C185592680 @default.
• W1939559612 hasConcept C202751555 @default.
• W1939559612 hasConcept C20719415 @default.
• W1939559612 hasConcept C2776200302 @default.
• W1939559612 hasConcept C2776795407 @default.
• W1939559612 hasConcept C2776909242 @default.
• W1939559612 hasConcept C2780159080 @default.
• W1939559612 hasConcept C535196362 @default.
• W1939559612 hasConcept C55493867 @default.
• W1939559612 hasConcept C62231903 @default.
• W1939559612 hasConcept C71924100 @default.
• W1939559612 hasConcept C86803240 @default.
• W1939559612 hasConcept C95444343 @default.
• W1939559612 hasConceptScore W1939559612C126322002 @default.
• W1939559612 hasConceptScore W1939559612C134018914 @default.
• W1939559612 hasConceptScore W1939559612C141071460 @default.
• W1939559612 hasConceptScore W1939559612C159110652 @default.
• W1939559612 hasConceptScore W1939559612C16613235 @default.
• W1939559612 hasConceptScore W1939559612C171056886 @default.
• W1939559612 hasConceptScore W1939559612C177322064 @default.
• W1939559612 hasConceptScore W1939559612C178790620 @default.
• W1939559612 hasConceptScore W1939559612C185592680 @default.
• W1939559612 hasConceptScore W1939559612C202751555 @default.
• W1939559612 hasConceptScore W1939559612C20719415 @default.
• W1939559612 hasConceptScore W1939559612C2776200302 @default.
• W1939559612 hasConceptScore W1939559612C2776795407 @default.
• W1939559612 hasConceptScore W1939559612C2776909242 @default.
• W1939559612 hasConceptScore W1939559612C2780159080 @default.
• W1939559612 hasConceptScore W1939559612C535196362 @default.
• W1939559612 hasConceptScore W1939559612C55493867 @default.
• W1939559612 hasConceptScore W1939559612C62231903 @default.
• W1939559612 hasConceptScore W1939559612C71924100 @default.
• W1939559612 hasConceptScore W1939559612C86803240 @default.
• W1939559612 hasConceptScore W1939559612C95444343 @default.
• W1939559612 hasIssue "1" @default.
• W1939559612 hasLocation W19395596121 @default.
• W1939559612 hasLocation W19395596122 @default.
• W1939559612 hasLocation W19395596123 @default.
• W1939559612 hasLocation W19395596124 @default.
• W1939559612 hasOpenAccess W1939559612 @default.
• W1939559612 hasPrimaryLocation W19395596121 @default.
• W1939559612 hasRelatedWork W1939559612 @default.
• W1939559612 hasRelatedWork W1970739379 @default.
• W1939559612 hasRelatedWork W1976459836 @default.
• W1939559612 hasRelatedWork W2022336279 @default.
• W1939559612 hasRelatedWork W2027748287 @default.
• W1939559612 hasRelatedWork W2086825515 @default.
• W1939559612 hasRelatedWork W2087570273 @default.
• W1939559612 hasRelatedWork W2094423915 @default.
• W1939559612 hasRelatedWork W2153915731 @default.
• W1939559612 hasRelatedWork W2371430120 @default.
• W1939559612 hasVolume "217" @default.

• next